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MGI:Dld
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Dld ( synonyms: branched chain alpha-keto acid dehydrogenase complex subunit E3, dihydrolipoyl dehydrogenase ) | |
| Protein Name(s) | dihydrolipoamide dehydrogenase, | |
| External Links | ||
| MGI | MGI:107450 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004148 |
dihydrolipoyl dehydrogenase activity |
MGI:MGI:1101694 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182403 |
F |
From MGI |
||
| GO:0004148 |
dihydrolipoyl dehydrogenase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
F |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2682130 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3589712 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3852644 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
C |
From MGI |
||
| GO:0006086 |
acetyl-CoA biosynthetic process from pyruvate |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
P |
From MGI |
||
| GO:0006103 |
2-oxoglutarate metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
P |
From MGI |
||
| GO:0006120 |
mitochondrial electron transport, NADH to ubiquinone |
MGI:MGI:3622835 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182403 |
P |
From MGI |
||
| GO:0006508 |
proteolysis |
MGI:MGI:3708027 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007369 |
gastrulation |
MGI:MGI:1101694 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182403 |
P |
From MGI |
||
| GO:0009106 |
lipoate metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
P |
From MGI |
||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0560 |
F |
From MGI |
||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR016156 |
F |
From MGI |
||
| GO:0016668 |
oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0019861 |
flagellum |
MGI:MGI:3589712 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042391 |
regulation of membrane potential |
MGI:MGI:3622835 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182403 |
P |
From MGI |
||
| GO:0043159 |
acrosomal matrix |
MGI:MGI:3589712 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043544 |
lipoamide binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
F |
From MGI |
||
| GO:0045252 |
oxoglutarate dehydrogenase complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
C |
From MGI |
||
| GO:0045254 |
pyruvate dehydrogenase complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
C |
From MGI |
||
| GO:0045454 |
cell redox homeostasis |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0048240 |
sperm capacitation |
MGI:MGI:3589712 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050660 |
flavin adenine dinucleotide binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
F |
From MGI |
||
| GO:0051068 |
dihydrolipoamide metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
P |
From MGI |
||
| GO:0051287 |
NAD binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_955417 |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Johnson MT et al. (1997) Targeted disruption of the murine dihydrolipoamide dehydrogenase gene (Dld) results in perigastrulation lethality. Proc Natl Acad Sci U S A 94: 14512-7 PubMed GONUTS page
- ↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Mitra K et al. (2005) Novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: correlation of its localization, tyrosine phosphorylation, and activity during sperm capacitation. J Biol Chem 280: 25743-53 PubMed GONUTS page
- ↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
- ↑ 5.0 5.1 Klivenyi P et al. (2004) Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. J Neurochem 88: 1352-60 PubMed GONUTS page
- ↑ Babady NE et al. (2007) Cryptic proteolytic activity of dihydrolipoamide dehydrogenase. Proc Natl Acad Sci U S A 104: 6158-63 PubMed GONUTS page
