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MGI:Dgat2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Dgat2 | |
| Protein Name(s) | diacylglycerol O-acyltransferase 2, | |
| External Links | ||
| MGI | MGI:1915050 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003846 |
2-acylglycerol O-acyltransferase activity |
MGI:MGI:2181469 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004144 |
diacylglycerol O-acyltransferase activity |
MGI:MGI:2151970 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004144 |
diacylglycerol O-acyltransferase activity |
MGI:MGI:2181469 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004144 |
diacylglycerol O-acyltransferase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001012345 |
F |
From MGI |
||
| GO:0004144 |
diacylglycerol O-acyltransferase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:2151970 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:2181469 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:3842895 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:3778742 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001012345 |
C |
From MGI |
||
| GO:0006071 |
glycerol metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0319 |
P |
From MGI |
||
| GO:0006629 |
lipid metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0443 |
P |
From MGI |
||
| GO:0008610 |
lipid biosynthetic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0444 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2151970 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016746 |
transferase activity, transferring acyl groups |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0012 |
F |
From MGI |
||
| GO:0016747 |
transferase activity, transferring acyl groups other than amino-acyl groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0019432 |
triglyceride biosynthetic process |
MGI:MGI:2151970 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019432 |
triglyceride biosynthetic process |
MGI:MGI:2181469 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019432 |
triglyceride biosynthetic process |
MGI:MGI:3036977 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3037903 |
P |
From MGI |
||
| GO:0019432 |
triglyceride biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019915 |
lipid storage |
MGI:MGI:5293272 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0019915 |
lipid storage |
MGI:MGI:5306738 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0030176 |
integral to endoplasmic reticulum membrane |
MGI:MGI:5293272 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0034383 |
low-density lipoprotein particle clearance |
MGI:MGI:3784112 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035336 |
long-chain fatty-acyl-CoA metabolic process |
MGI:MGI:2151970 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035336 |
long-chain fatty-acyl-CoA metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035356 |
cellular triglyceride homeostasis |
MGI:MGI:3036977 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042632 |
cholesterol homeostasis |
MGI:MGI:3778742 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:5293272 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0046339 |
diacylglycerol metabolic process |
MGI:MGI:2151970 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046339 |
diacylglycerol metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:3842895 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0055089 |
fatty acid homeostasis |
MGI:MGI:3778742 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0060613 |
fat pad development |
MGI:MGI:3778742 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0071400 |
cellular response to oleic acid |
MGI:MGI:5293272 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0097006 |
regulation of plasma lipoprotein particle levels |
MGI:MGI:3778742 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
|
colocalizes_with |
GO:0005739 |
mitochondrion |
MGI:MGI:3842895 |
IDA: Inferred from Direct Assay |
C |
From MGI |
||
|
colocalizes_with |
GO:0005811 |
lipid particle |
MGI:MGI:3842895 |
IDA: Inferred from Direct Assay |
C |
From MGI |
||
|
colocalizes_with |
GO:0005811 |
lipid particle |
MGI:MGI:5293272 |
IDA: Inferred from Direct Assay |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Yen CL et al. (2002) Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc Natl Acad Sci U S A 99: 8512-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Cases S et al. (2001) Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem 276: 38870-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Stone SJ et al. (2009) The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem 284: 5352-61 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Liu Y et al. (2008) Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice. Biochim Biophys Acta 1781: 97-104 PubMed GONUTS page
- ↑ 5.0 5.1 Stone SJ et al. (2004) Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem 279: 11767-76 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 McFie PJ et al. (2011) Murine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum. J Biol Chem 286: 28235-46 PubMed GONUTS page
- ↑ Harris CA et al. (2011) DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes. J Lipid Res 52: 657-67 PubMed GONUTS page
- ↑ Minahk C et al. (2008) Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem 283: 6449-58 PubMed GONUTS page
