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MGI:Dag1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Dag1 ( synonyms: alpha-dystroglycan, beta-dystroglycan, D9Wsu13e, DG, dystrophin associated glycoprotein 1 ) | |
| Protein Name(s) | dystroglycan 1, | |
| External Links | ||
| MGI | MGI:101864 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002011 |
morphogenesis of an epithelial sheet |
MGI:MGI:2156962 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003779 |
actin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1927714 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2156962 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2181307 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3511446 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3806169 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005604 |
basement membrane |
MGI:MGI:1202096 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005604 |
basement membrane |
MGI:MGI:2156962 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005604 |
basement membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005626 |
insoluble fraction |
MGI:MGI:3028713 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From MGI |
||
| GO:0005654 |
nucleoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1927714 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2181307 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3028713 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005913 |
cell-cell adherens junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
C |
From MGI |
||
| GO:0005925 |
focal adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
C |
From MGI |
||
| GO:0006509 |
membrane protein ectodomain proteolysis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006607 |
NLS-bearing substrate import into nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007016 |
cytoskeletal anchoring at plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008307 |
structural constituent of muscle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009279 |
cell outer membrane |
MGI:MGI:2663553 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0014044 |
Schwann cell development |
MGI:MGI:2663553 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0015631 |
tubulin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016010 |
dystrophin-associated glycoprotein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
C |
From MGI |
||
| GO:0016010 |
dystrophin-associated glycoprotein complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016011 |
dystroglycan complex |
MGI:MGI:2156962 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016323 |
basolateral plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
C |
From MGI |
||
| GO:0016340 |
calcium-dependent cell-matrix adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
P |
From MGI |
||
| GO:0017166 |
vinculin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019048 |
virus-host interaction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0021682 |
nerve maturation |
MGI:MGI:2663553 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0022011 |
myelination in peripheral nervous system |
MGI:MGI:2663553 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030027 |
lamellipodium |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030175 |
filopodium |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030336 |
negative regulation of cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
F |
From MGI |
||
| GO:0033268 |
node of Ranvier |
MGI:MGI:2663553 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0034453 |
microtubule anchoring |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042169 |
SH2 domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:1202217 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:1928619 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:2135840 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
C |
From MGI |
||
| GO:0043034 |
costamere |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
C |
From MGI |
||
| GO:0043409 |
negative regulation of MAPK cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044419 |
interspecies interaction between organisms |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0945 |
P |
From MGI |
||
| GO:0045121 |
membrane raft |
MGI:MGI:2135840 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0051393 |
alpha-actinin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051635 |
bacterial cell surface binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001074892 |
F |
From MGI |
||
| GO:0051898 |
negative regulation of protein kinase B signaling cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060441 |
epithelial tube branching involved in lung morphogenesis |
MGI:MGI:2156962 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060445 |
branching involved in salivary gland morphogenesis |
MGI:MGI:2156962 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070938 |
contractile ring |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Durbeej M et al. (2001) Dystroglycan binding to laminin alpha1LG4 module influences epithelial morphogenesis of salivary gland and lung in vitro. Differentiation 69: 121-34 PubMed GONUTS page
- ↑ 2.0 2.1 Sotgia F et al. (2000) Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members. J Biol Chem 275: 38048-58 PubMed GONUTS page
- ↑ 3.0 3.1 Sherman DL et al. (2001) Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy. Neuron 30: 677-87 PubMed GONUTS page
- ↑ Rentschler S et al. (1999) The WW domain of dystrophin requires EF-hands region to interact with beta-dystroglycan. Biol Chem 380: 431-42 PubMed GONUTS page
- ↑ Sato S et al. (2008) Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nat Neurosci 11: 923-31 PubMed GONUTS page
- ↑ Durbeej M et al. (1998) Distribution of dystroglycan in normal adult mouse tissues. J Histochem Cytochem 46: 449-57 PubMed GONUTS page
- ↑ 7.0 7.1 Koh TJ & Escobedo J (2004) Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions. Am J Physiol Cell Physiol 286: C713-22 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Saito F et al. (2003) Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization. Neuron 38: 747-58 PubMed GONUTS page
- ↑ Liang B et al. (1998) Injection of T-cell receptor peptide reduces immunosenescence in aged C57BL/6 mice. Immunology 93: 462-8 PubMed GONUTS page
- ↑ Hagiwara Y et al. (2000) Caveolin-3 deficiency causes muscle degeneration in mice. Hum Mol Genet 9: 3047-54 PubMed GONUTS page
- ↑ 11.0 11.1 Galbiati F et al. (2001) Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities. J Biol Chem 276: 21425-33 PubMed GONUTS page
