MGI:Dab2ip

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0005096	GTPase activator activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0343	F	From MGI
	GO:0005096	GTPase activator activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001936	F	From MGI
	GO:0005099	Ras GTPase activator activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_619724	F	From MGI
	GO:0005099	Ras GTPase activator activity	MGI:MGI:4459044		PANTHER:PTHR10194	F	From MGI
	GO:0005123	death receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2671692 PMID:12877983^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P97318	F	From MGI
	GO:0005543	phospholipid binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001849	F	From MGI
	GO:0005622	intracellular	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001936 InterPro:IPR008936	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4459044		PANTHER:PTHR10194	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	C	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008936	P	From MGI
	GO:0007257	activation of JUN kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0009967	positive regulation of signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0010719	negative regulation of epithelial to mesenchymal transition	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	F	From MGI
	GO:0030308	negative regulation of cell growth	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_619724	P	From MGI
	GO:0031235	intrinsic to internal side of plasma membrane	MGI:MGI:4459044		PANTHER:PTHR10194	C	From MGI
	GO:0031435	mitogen-activated protein kinase kinase kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	F	From MGI
	GO:0032088	negative regulation of NF-kappaB transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0032320	positive regulation of Ras GTPase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_619724	P	From MGI
	GO:0032320	positive regulation of Ras GTPase activity	MGI:MGI:4459044		PANTHER:PTHR10194	P	From MGI
	GO:0034261	negative regulation of Ras GTPase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0035414	negative regulation of catenin import into nucleus	MGI:MGI:4431163 PMID:20080667^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0035591	signaling adaptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	F	From MGI
	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_619724	P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	F	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4398763 PMID:19903888^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0043407	negative regulation of MAP kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0043507	positive regulation of JUN kinase activity	MGI:MGI:3796479 PMID:18281285^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043507	positive regulation of JUN kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0043547	positive regulation of GTPase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0343	P	From MGI
	GO:0043547	positive regulation of GTPase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001936	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0046580	negative regulation of Ras protein signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_619724	P	From MGI
	GO:0046580	negative regulation of Ras protein signal transduction	MGI:MGI:4459044		PANTHER:PTHR10194	P	From MGI
	GO:0047485	protein N-terminus binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_619724	F	From MGI
	GO:0048147	negative regulation of fibroblast proliferation	MGI:MGI:4887526 PMID:20154697^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050680	negative regulation of epithelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0051056	regulation of small GTPase mediated signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001936	P	From MGI
	GO:0051721	protein phosphatase 2A binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	F	From MGI
	GO:0070059	apoptosis in response to endoplasmic reticulum stress	MGI:MGI:3796479 PMID:18281285^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071356	cellular response to tumor necrosis factor	MGI:MGI:3796479 PMID:18281285^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071356	cellular response to tumor necrosis factor	MGI:MGI:4398763 PMID:19903888^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071356	cellular response to tumor necrosis factor	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0071364	cellular response to epidermal growth factor stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_619724	P	From MGI
	GO:0071889	14-3-3 protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	F	From MGI
	GO:0071901	negative regulation of protein serine/threonine kinase activity	MGI:MGI:4398763 PMID:19903888^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071901	negative regulation of protein serine/threonine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0071902	positive regulation of protein serine/threonine kinase activity	MGI:MGI:4398763 PMID:19903888^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071902	positive regulation of protein serine/threonine kinase activity	MGI:MGI:4431163 PMID:20080667^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071902	positive regulation of protein serine/threonine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5VWQ8	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Homayouni R et al. (2003) Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain. Brain Res Mol Brain Res 115: 121-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Xie D et al. (2010) Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A 107: 2485-90 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Xie D et al. (2009) DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis. Proc Natl Acad Sci U S A 106: 19878-83 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Luo D et al. (2008) AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem 283: 11905-12 PubMed GONUTS page
↑ Min J et al. (2010) An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med 16: 286-94 PubMed GONUTS page

[PMID:12877983-0] Homayouni R et al. (2003) Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain. Brain Res Mol Brain Res 115: 121-9 PubMed GONUTS page

[PMID:20080667-1] 2.0 ^2.1 Xie D et al. (2010) Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A 107: 2485-90 PubMed GONUTS page

[PMID:19903888-2] 3.0 ^3.1 ^3.2 ^3.3 Xie D et al. (2009) DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis. Proc Natl Acad Sci U S A 106: 19878-83 PubMed GONUTS page

[PMID:18281285-3] 4.0 ^4.1 ^4.2 Luo D et al. (2008) AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem 283: 11905-12 PubMed GONUTS page

[PMID:20154697-4] Min J et al. (2010) An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med 16: 286-94 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Dab2ip ( synonyms: AIP1 )
Protein Name(s)	disabled homolog 2 (Drosophila) interacting protein,
External Links
MGI	MGI:1916851

MGI:Dab2ip

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Annotations

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References

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