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MGI:Dab2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Dab2 ( synonyms: D15Wsu122e, p96 ) | |
| Protein Name(s) | disabled homolog 2 (Drosophila), | |
| External Links | ||
| MGI | MGI:109175 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000904 |
cell morphogenesis involved in differentiation |
MGI:MGI:2389502 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2429678 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:2389502 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2429678 |
P |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1345903 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1929027 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2664441 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3609432 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1929027 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1929027 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4946462 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005905 |
coated pit |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:2389502 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0006907 |
pinocytosis |
MGI:MGI:3610714 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387168 |
P |
From MGI |
||
| GO:0007588 |
excretion |
MGI:MGI:2178022 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387168 |
P |
From MGI |
||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016324 |
apical plasma membrane |
MGI:MGI:4946462 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031410 |
cytoplasmic vesicle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0968 |
C |
From MGI |
||
| GO:0032091 |
negative regulation of protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000096 |
positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Yang DH et al. (2002) Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev Biol 251: 27-44 PubMed GONUTS page
- ↑ Duncan RR et al. (1999) Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo. J Biol Chem 274: 27347-50 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Cho SY et al. (2000) p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells. Biochem J 352 Pt 3: 645-50 PubMed GONUTS page
- ↑ Hocevar BA et al. (2003) Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J 22: 3084-94 PubMed GONUTS page
- ↑ Choi YJ et al. (2005) Cloning and characterization of mouse disabled 2 interacting protein 2, a mouse orthologue of human NOSTRIN. Biochem Biophys Res Commun 326: 594-9 PubMed GONUTS page
- ↑ 6.0 6.1 Artus J et al. (2011) The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol 350: 393-404 PubMed GONUTS page
- ↑ Maurer ME & Cooper JA (2005) Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein. J Cell Sci 118: 5345-55 PubMed GONUTS page
- ↑ Morris SM et al. (2002) Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J 21: 1555-64 PubMed GONUTS page
