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MGI:Cyr61
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cyr61 ( synonyms: CCN1 ) | |
| Protein Name(s) | cysteine rich protein 61, | |
| External Links | ||
| MGI | MGI:88613 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001558 |
regulation of cell growth |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3620470 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98956 |
P |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002041 |
intussusceptive angiogenesis |
MGI:MGI:2446415 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2446577 |
P |
From MGI |
||
| GO:0003181 |
atrioventricular valve morphogenesis |
MGI:MGI:3761425 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2446577 |
P |
From MGI |
||
| GO:0003278 |
apoptotic process involved in heart morphogenesis |
MGI:MGI:3761425 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2446577 |
P |
From MGI |
||
| GO:0003281 |
ventricular septum development |
MGI:MGI:3761425 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2446577 |
P |
From MGI |
||
| GO:0005178 |
integrin binding |
MGI:MGI:2673745 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005520 |
insulin-like growth factor binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0006935 |
chemotaxis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112617 |
P |
From MGI |
||
| GO:0007155 |
cell adhesion |
MGI:MGI:2673745 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112617 |
P |
From MGI |
||
| GO:0008201 |
heparin binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0358 |
F |
From MGI |
||
| GO:0010518 |
positive regulation of phospholipase activity |
MGI:MGI:3849354 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010811 |
positive regulation of cell-substrate adhesion |
MGI:MGI:3807344 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016337 |
cell-cell adhesion |
MGI:MGI:1195020 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019838 |
growth factor binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0340 |
F |
From MGI |
||
| GO:0030198 |
extracellular matrix organization |
MGI:MGI:3807344 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:3620470 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030513 |
positive regulation of BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033690 |
positive regulation of osteoblast proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:3849354 |
IGI: Inferred from Genetic Interaction |
UniPRotKB:P48023 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3761425 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2446577 |
P |
From MGI |
||
| GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:3849354 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0044319 |
wound healing, spreading of cells |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045597 |
positive regulation of cell differentiation |
MGI:MGI:1195020 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045860 |
positive regulation of protein kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050840 |
extracellular matrix binding |
MGI:MGI:3807344 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0060413 |
atrial septum morphogenesis |
MGI:MGI:3761425 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2446577 |
P |
From MGI |
||
| GO:0060591 |
chondroblast differentiation |
MGI:MGI:1195020 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060710 |
chorio-allantoic fusion |
MGI:MGI:2446415 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2446577 |
P |
From MGI |
||
| GO:0060716 |
labyrinthine layer blood vessel development |
MGI:MGI:2446415 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2446577 |
P |
From MGI |
||
| GO:0061036 |
positive regulation of cartilage development |
MGI:MGI:1195020 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070372 |
regulation of ERK1 and ERK2 cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0072593 |
reactive oxygen species metabolic process |
MGI:MGI:3849354 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:2000304 |
positive regulation of ceramide biosynthetic process |
MGI:MGI:3849354 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Si W et al. (2006) CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol 26: 2955-64 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Mo FE et al. (2002) CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol 22: 8709-20 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Mo FE & Lau LF (2006) The matricellular protein CCN1 is essential for cardiac development. Circ Res 99: 961-9 PubMed GONUTS page
- ↑ 4.0 4.1 Leu SJ et al. (2003) Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61). J Biol Chem 278: 33801-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Juric V et al. (2009) Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol Cell Biol 29: 3266-79 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Manabe R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A 105: 12849-54 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Wong M et al. (1997) Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells. Dev Biol 192: 492-508 PubMed GONUTS page
