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MGI:Cyp1b1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cyp1b1 | |
| Protein Name(s) | cytochrome P450, family 1, subfamily b, polypeptide 1, | |
| External Links | ||
| MGI | MGI:88590 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001525 |
angiogenesis |
MGI:MGI:3829820 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154690 |
P |
From MGI |
||
| GO:0004497 |
monooxygenase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0503 |
F |
From MGI |
||
| GO:0005506 |
iron ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0256 |
C |
From MGI |
||
| GO:0005792 |
microsome |
MGI:MGI:3713192 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:82204 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006725 |
cellular aromatic compound metabolic process |
MGI:MGI:1097753 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006725 |
cellular aromatic compound metabolic process |
MGI:MGI:1099570 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006725 |
cellular aromatic compound metabolic process |
MGI:MGI:1333452 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154690 |
P |
From MGI |
||
| GO:0006725 |
cellular aromatic compound metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006725 |
cellular aromatic compound metabolic process |
MGI:MGI:82204 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008210 |
estrogen metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009055 |
electron carrier activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0009404 |
toxin metabolic process |
MGI:MGI:1333452 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154690 |
P |
From MGI |
||
| GO:0009404 |
toxin metabolic process |
MGI:MGI:3713192 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154690 |
P |
From MGI |
||
| GO:0009636 |
response to toxin |
MGI:MGI:3794487 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154690 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
MGI:MGI:1099570 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0020037 |
heme binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0043542 |
endothelial cell migration |
MGI:MGI:3829820 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154690 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0055114 |
oxidation-reduction process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0061298 |
retina vasculature development in camera-type eye |
MGI:MGI:3829820 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154690 |
P |
From MGI |
||
| GO:0070330 |
aromatase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0071603 |
endothelial cell-cell adhesion |
MGI:MGI:3829820 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154690 |
P |
From MGI |
||
|
NOT |
GO:0018894 |
dibenzo-p-dioxin metabolic process |
MGI:MGI:3688815 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154690 |
P |
From MGI |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Tang Y et al. (2009) CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression. Blood 113: 744-54 PubMed GONUTS page
- ↑ 2.0 2.1 Shertzer HG et al. (2007) 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis 28: 1371-8 PubMed GONUTS page
- ↑ 3.0 3.1 Pottenger LH et al. (1991) Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. Arch Biochem Biophys 286: 488-97 PubMed GONUTS page
- ↑ Alexander DL et al. (1997) Ah receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells. Cancer Res 57: 4498-506 PubMed GONUTS page
- ↑ 5.0 5.1 Savas U et al. (1997) Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1. Arch Biochem Biophys 347: 181-92 PubMed GONUTS page
- ↑ 6.0 6.1 Buters JT et al. (1999) Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas. Proc Natl Acad Sci U S A 96: 1977-82 PubMed GONUTS page
- ↑ Uno S et al. (2006) Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Mol Pharmacol 69: 1103-14 PubMed GONUTS page
- ↑ Dragin N et al. (2006) For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. J Biol Chem 281: 18591-600 PubMed GONUTS page
