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MGI:Cx3cl1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cx3cl1 ( synonyms: CX3C, D8Bwg0439e, fractalkine, neurotactin, Scyd1 ) | |
| Protein Name(s) | chemokine (C-X3-C motif) ligand 1, | |
| External Links | ||
| MGI | MGI:1097153 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005125 |
cytokine activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0202 |
F |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0202 |
C |
From MGI |
||
| GO:0005625 |
soluble fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006935 |
chemotaxis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0130 |
P |
From MGI |
||
| GO:0008009 |
chemokine activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008009 |
chemokine activity |
MGI:MGI:892218 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:892218 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0010759 |
positive regulation of macrophage chemotaxis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:3833195 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030168 |
platelet activation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030593 |
neutrophil chemotaxis |
MGI:MGI:892218 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032914 |
positive regulation of transforming growth factor beta1 production |
MGI:MGI:3772530 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3608773 |
P |
From MGI |
||
| GO:0042060 |
wound healing |
MGI:MGI:3772530 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3608773 |
P |
From MGI |
||
| GO:0042995 |
cell projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3777228 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3833195 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045766 |
positive regulation of angiogenesis |
MGI:MGI:3767138 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045785 |
positive regulation of cell adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045906 |
negative regulation of vasoconstriction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048246 |
macrophage chemotaxis |
MGI:MGI:3703135 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048247 |
lymphocyte chemotaxis |
MGI:MGI:892218 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048661 |
positive regulation of smooth muscle cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050710 |
negative regulation of cytokine secretion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051041 |
positive regulation of calcium-independent cell-cell adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060055 |
angiogenesis involved in wound healing |
MGI:MGI:3772530 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3608773 |
P |
From MGI |
||
| GO:0060080 |
regulation of inhibitory postsynaptic membrane potential |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Pan Y et al. (1997) Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 387: 611-7 PubMed GONUTS page
- ↑ 2.0 2.1 Landsman L et al. (2009) CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood 113: 963-72 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Ishida Y et al. (2008) Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function. J Immunol 180: 569-79 PubMed GONUTS page
- ↑ Lu P et al. (2008) Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression. J Immunol 180: 4283-91 PubMed GONUTS page
- ↑ Ren T et al. (2007) Down-regulation of surface fractalkine by RNA interference in B16 melanoma reduced tumor growth in mice. Biochem Biophys Res Commun 364: 978-84 PubMed GONUTS page
- ↑ Suzuki F et al. (2005) Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice. J Immunol 175: 6987-96 PubMed GONUTS page
