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MGI:Cux1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Cux1 ( synonyms: CDP, Cutl1, Cux, Cux-1 )
Protein Name(s) cut-like homeobox 1,
External Links
MGI MGI:88568

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:2149924
PMID:11544187[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000139

Golgi membrane

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P53565

C

From MGI

GO:0000301

retrograde transport, vesicle recycling within Golgi

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P53565

P

From MGI

GO:0003677

DNA binding

MGI:MGI:3531237
PMID:15656993[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3589706
PMID:15994318[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

From MGI

GO:0005634

nucleus

MGI:MGI:2149924
PMID:11544187[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2158919
PMID:11839809[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P39880

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P39880

C

From MGI

GO:0005794

Golgi apparatus

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0333

C

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR017970
InterPro:IPR001356

P

From MGI

GO:0006810

transport

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From MGI

GO:0006891

intra-Golgi vesicle-mediated transport

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR012955

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0030173

integral to Golgi membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR012955

C

From MGI

GO:0030324

lung development

MGI:MGI:2149924
PMID:11544187[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2388352

P

From MGI

GO:0030674

protein binding, bridging

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P53565

F

From MGI

GO:0042491

auditory receptor cell differentiation

MGI:MGI:2149924
PMID:11544187[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2388352

P

From MGI

GO:0043565

sequence-specific DNA binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR017970
InterPro:IPR001356

F

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Ellis T et al. (2001) The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle. Genes Dev 15: 2307-19 PubMed GONUTS page
  2. Gingras H et al. (2005) Biochemical characterization of the mammalian Cux2 protein. Gene 344: 273-85 PubMed GONUTS page
  3. Huang CJ et al. (2005) Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. J Biol Chem 280: 30681-8 PubMed GONUTS page
  4. Luong MX et al. (2002) Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol Cell Biol 22: 1424-37 PubMed GONUTS page
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