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MGI:Cubn
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cubn ( synonyms: D2Wsu88e ) | |
| Protein Name(s) | cubilin (intrinsic factor-cobalamin receptor), | |
| External Links | ||
| MGI | MGI:1931256 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001701 |
in utero embryonic development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1931078 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2179173 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2179173 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0458 |
C |
From MGI |
||
| GO:0005768 |
endosome |
MGI:MGI:1931078 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005768 |
endosome |
MGI:MGI:2667584 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:3577702 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:3577702 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005903 |
brush border |
MGI:MGI:2667584 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005905 |
coated pit |
MGI:MGI:3577702 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006629 |
lipid metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0443 |
P |
From MGI |
||
| GO:0006810 |
transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0813 |
P |
From MGI |
||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:3577702 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007584 |
response to nutrient |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008202 |
steroid metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0753 |
P |
From MGI |
||
| GO:0008203 |
cholesterol metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0153 |
P |
From MGI |
||
| GO:0015031 |
protein transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0653 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016324 |
apical plasma membrane |
MGI:MGI:3577702 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0020028 |
hemoglobin import |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030139 |
endocytic vesicle |
MGI:MGI:3577702 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030492 |
hemoglobin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030666 |
endocytic vesicle membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031419 |
cobalamin binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0846 |
F |
From MGI |
||
| GO:0031526 |
brush border membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042953 |
lipoprotein transport |
MGI:MGI:3577702 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043202 |
lysosomal lumen |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045177 |
apical part of cell |
MGI:MGI:2179173 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045177 |
apical part of cell |
MGI:MGI:3577702 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045177 |
apical part of cell |
MGI:MGI:3578036 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0070207 |
protein homotrimerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Hammad SM et al. (2000) Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins. J Biol Chem 275: 12003-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Crider-Pirkle S et al. (2002) Cubilin, a binding partner for galectin-3 in the murine utero-placental complex. J Biol Chem 277: 15904-12 PubMed GONUTS page
- ↑ 3.0 3.1 Christensen EI et al. (2003) Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules. Proc Natl Acad Sci U S A 100: 8472-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Assémat E et al. (2005) Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo. Biol Reprod 72: 1079-86 PubMed GONUTS page
- ↑ Strope S et al. (2004) Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules. Development 131: 4787-95 PubMed GONUTS page
