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MGI:Ctnnb1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ctnnb1 ( synonyms: beta catenin, beta-catenin, Catnb )
Protein Name(s) catenin (cadherin associated protein), beta 1,
External Links
MGI MGI:88276

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:3613282
PMID:16040629[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000578

embryonic axis specification

MGI:MGI:894149
PMID:9230313[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000904

cell morphogenesis involved in differentiation

MGI:MGI:3603687
PMID:16102745[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3045749

P

From MGI

GO:0001501

skeletal system development

MGI:MGI:3578464
PMID:15866163[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148591
MGI:MGI:2148594
MGI:MGI:2450929

P

From MGI

GO:0001569

patterning of blood vessels

MGI:MGI:2675534
PMID:12975353[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0001569

patterning of blood vessels

MGI:MGI:3833040
PMID:19154719[6]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0001570

vasculogenesis

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0001658

branching involved in ureteric bud morphogenesis

MGI:MGI:3714576
PMID:17537789[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0001701

in utero embryonic development

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0001701

in utero embryonic development

MGI:MGI:3840033
PMID:19204372[9]

IGI: Inferred from Genetic Interaction

MGI:MGI:1096327

P

From MGI

GO:0001702

gastrulation with mouth forming second

MGI:MGI:77405
PMID:8582267[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857678

P

From MGI

GO:0001706

endoderm formation

MGI:MGI:3625553
PMID:12194849[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:1858007

P

From MGI

GO:0001708

cell fate specification

MGI:MGI:3578464
PMID:15866163[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148591
MGI:MGI:2148594
MGI:MGI:2450929

P

From MGI

GO:0001709

cell fate determination

MGI:MGI:3529734
PMID:15708565[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:2176173

P

From MGI

GO:0001711

endodermal cell fate commitment

MGI:MGI:3625553
PMID:12194849[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:1858007

P

From MGI

GO:0001764

neuron migration

MGI:MGI:5294271
PMID:21937711[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:1334448

P

From MGI

GO:0001822

kidney development

MGI:MGI:3714576
PMID:17537789[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0001889

liver development

MGI:MGI:4459044

PANTHER:PTHR23315

P

From MGI

GO:0002052

positive regulation of neuroblast proliferation

MGI:MGI:5294271
PMID:21937711[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:1334448

P

From MGI

GO:0002053

positive regulation of mesenchymal cell proliferation

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0002053

positive regulation of mesenchymal cell proliferation

MGI:MGI:3801531
PMID:18533146[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0002089

lens morphogenesis in camera-type eye

MGI:MGI:3603687
PMID:16102745[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3045749

P

From MGI

GO:0003136

negative regulation of heart induction by canonical Wnt receptor signaling pathway

MGI:MGI:4459044

PANTHER:PTHR23315

P

From MGI

GO:0003223

ventricular compact myocardium morphogenesis

MGI:MGI:4943617
PMID:20299672[15]

TAS: Traceable Author Statement

P

From MGI

GO:0003266

regulation of secondary heart field cardioblast proliferation

MGI:MGI:4438134
PMID:19620969[16]

IDA: Inferred from Direct Assay

P

From MGI

GO:0003337

mesenchymal to epithelial transition involved in metanephros morphogenesis

MGI:MGI:3714576
PMID:17537789[8]

IDA: Inferred from Direct Assay

P

From MGI

GO:0003338

metanephros morphogenesis

MGI:MGI:3821953
PMID:19060336[17]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0003677

DNA binding

MGI:MGI:2386811
PMID:12235125[18]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3038034
PMID:15024079[19]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3579620
PMID:15778706[20]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3582095
PMID:15907834[21]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3620470
PMID:16581771[22]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3690195
PMID:16678101[23]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3701031
PMID:16818445[24]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3759355
PMID:17767158[25]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:4355652
PMID:19619491[26]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:4359548
PMID:19690384[27]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:4438134
PMID:19620969[16]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:4439199
PMID:20159597[28]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:4948149
PMID:21512031[29]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003690

double-stranded DNA binding

MGI:MGI:3690195
PMID:16678101[23]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:2386811
PMID:12235125[18]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003713

transcription coactivator activity

MGI:MGI:2446944
PMID:12464179[30]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003713

transcription coactivator activity

MGI:MGI:2675528
PMID:12949260[31]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003713

transcription coactivator activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0005198

structural molecule activity

MGI:MGI:4459044

PANTHER:PTHR23315

F

From MGI

GO:0005515

protein binding

MGI:MGI:1196720
PMID:9488439[32]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Z1J1
UniProtKB:Q924A0

F

From MGI

GO:0005515

protein binding

MGI:MGI:1336856
PMID:10318824[33]

IPI: Inferred from Physical Interaction

UniProtKB:O35625

F

From MGI

GO:0005515

protein binding

MGI:MGI:1355058
PMID:10882138[34]

IPI: Inferred from Physical Interaction

UniProtKB:P26231

F

From MGI

GO:0005515

protein binding

MGI:MGI:1931728
PMID:11104755[35]

IPI: Inferred from Physical Interaction

UniProtKB:P49768

F

From MGI

GO:0005515

protein binding

MGI:MGI:2447521
PMID:12432063[36]

IPI: Inferred from Physical Interaction

UniProtKB:Q60737

F

From MGI

GO:0005515

protein binding

MGI:MGI:2656687
PMID:12695331[37]

IPI: Inferred from Physical Interaction

UniProtKB:P46662

F

From MGI

GO:0005515

protein binding

MGI:MGI:2668307
PMID:12861022[38]

IPI: Inferred from Physical Interaction

UniProtKB:Q924A0

F

From MGI

GO:0005515

protein binding

MGI:MGI:2677113
PMID:12874278[39]

IPI: Inferred from Physical Interaction

UniProtKB:Q9DBG9
UniProtKB:Q924A0
UniProtKB:Q61315
UniProtKB:Q9WV60
UniProtKB:Q9JJN6

F

From MGI

GO:0005515

protein binding

MGI:MGI:3027450
PMID:14647292[40]

IPI: Inferred from Physical Interaction

UniProtKB:P26231

F

From MGI

GO:0005515

protein binding

MGI:MGI:3042352
PMID:14960280[41]

IPI: Inferred from Physical Interaction

UniProtKB:Q9D0S4

F

From MGI

GO:0005515

protein binding

MGI:MGI:3053243
PMID:15327768[42]

IPI: Inferred from Physical Interaction

UniProtKB:Q61315
UniProtKB:O35625

F

From MGI

GO:0005515

protein binding

MGI:MGI:3512829
PMID:15574752[43]

IPI: Inferred from Physical Interaction

UniProtKB:Q67FY2
UniProtKB:Q9D219

F

From MGI

GO:0005515

protein binding

MGI:MGI:3577701
PMID:15781477[44]

IPI: Inferred from Physical Interaction

UniProtKB:P48432

F

From MGI

GO:0005515

protein binding

MGI:MGI:3578508
PMID:15834408[45]

IPI: Inferred from Physical Interaction

UniProtKB:P70188
UniProtKB:Q61771
UniProtKB:P15116
UniProtKB:P30999

F

From MGI

GO:0005515

protein binding

MGI:MGI:3616385
PMID:16368433[46]

IPI: Inferred from Physical Interaction

UniProtKB:P09803

F

From MGI

GO:0005515

protein binding

MGI:MGI:3687818
PMID:10954424[47]

IPI: Inferred from Physical Interaction

UniProtKB:P60766

F

From MGI

GO:0005515

protein binding

MGI:MGI:3690195
PMID:16678101[23]

IPI: Inferred from Physical Interaction

UniProtKB:P97458

F

From MGI

GO:0005515

protein binding

MGI:MGI:3694173
PMID:16293619[48]

IPI: Inferred from Physical Interaction

UniProtKB:O15169
UniProtKB:P09803
UniProtKB:P25054
UniProtKB:P27782
UniProtKB:Q9NSA3

F

From MGI

GO:0005515

protein binding

MGI:MGI:3784902
PMID:18202148[49]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Z1J1
UniProtKB:P27782
UniProtKB:P19785

F

From MGI

GO:0005515

protein binding

MGI:MGI:3814765
PMID:18636119[50]

IPI: Inferred from Physical Interaction

UniProtKB:P97792

F

From MGI

GO:0005515

protein binding

MGI:MGI:3817405
PMID:18632848[51]

IPI: Inferred from Physical Interaction

UniProtKB:O35625

F

From MGI

GO:0005515

protein binding

MGI:MGI:4359141
PMID:19503085[52]

IPI: Inferred from Physical Interaction

UniProtKB:Q924A0

F

From MGI

GO:0005515

protein binding

MGI:MGI:4362003
PMID:16611247[53]

IPI: Inferred from Physical Interaction

UniProtKB:Q80U72

F

From MGI

GO:0005515

protein binding

MGI:MGI:4365512
PMID:19458197[54]

IPI: Inferred from Physical Interaction

UniProtKB:Q80U72

F

From MGI

GO:0005515

protein binding

MGI:MGI:4365886
PMID:19725955[55]

IPI: Inferred from Physical Interaction

UniProtKB:Q04887

F

From MGI

GO:0005515

protein binding

MGI:MGI:4820667
PMID:20413591[56]

IPI: Inferred from Physical Interaction

UniProtKB:Q9EPK8

F

From MGI

GO:0005515

protein binding

MGI:MGI:4839458
PMID:12408825[57]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NSA3

F

From MGI

GO:0005515

protein binding

MGI:MGI:4887291
PMID:20802155[58]

IPI: Inferred from Physical Interaction

UniProtKB:Q61473

F

From MGI

GO:0005515

protein binding

MGI:MGI:4948149
PMID:21512031[29]

IPI: Inferred from Physical Interaction

UniProtKB:P46938

F

From MGI

GO:0005515

protein binding

MGI:MGI:5294497
PMID:21751375[59]

IPI: Inferred from Physical Interaction

UniProtKB:P45481

F

From MGI

GO:0005515

protein binding

MGI:MGI:5315371
PMID:11348595[60]

IPI: Inferred from Physical Interaction

UniProtKB:P09803

F

From MGI

GO:0005624

membrane fraction

MGI:MGI:2447521
PMID:12432063[36]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005624

membrane fraction

MGI:MGI:2662669
PMID:12611902[61]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005624

membrane fraction

MGI:MGI:3028451
PMID:14657280[62]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2154850
PMID:11731231[63]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2154862
PMID:11731265[64]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2159585
PMID:11872843[65]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2670493
PMID:12923052[66]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2677113
PMID:12874278[39]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2677587
PMID:12885771[67]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3055626
PMID:15371327[68]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3512829
PMID:15574752[43]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3578464
PMID:15866163[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3578468
PMID:15866165[69]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3579620
PMID:15778706[20]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3617131
PMID:16439479[70]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3619173
PMID:16489008[71]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3640895
PMID:16678815[72]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3656361
PMID:16936075[73]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3688953
PMID:16989802[74]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3696593
PMID:17128274[75]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3715559
PMID:17615359[76]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3716020
PMID:17560563[77]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3720546
PMID:17596282[78]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3849215
PMID:19497282[79]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3850932
PMID:19213727[80]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4367296
PMID:19796622[81]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

C

From MGI

GO:0005634

nucleus

MGI:MGI:4429763
PMID:19850029[82]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0005667

transcription factor complex

MGI:MGI:2446944
PMID:12464179[30]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005667

transcription factor complex

MGI:MGI:2668307
PMID:12861022[38]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005667

transcription factor complex

MGI:MGI:3690195
PMID:16678101[23]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005667

transcription factor complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2154850
PMID:11731231[63]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2154862
PMID:11731265[64]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2386811
PMID:12235125[18]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2670493
PMID:12923052[66]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3036437
PMID:14981260[83]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3512701
PMID:15525667[84]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3512829
PMID:15574752[43]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3619173
PMID:16489008[71]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3696593
PMID:17128274[75]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3850932
PMID:19213727[80]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0005813

centrosome

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0005813

centrosome

MGI:MGI:4835108
PMID:20300119[85]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005829

cytosol

MGI:MGI:2385552
PMID:12055200[86]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005829

cytosol

MGI:MGI:3581945
PMID:15673614[87]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005829

cytosol

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

C

From MGI

GO:0005829

cytosol

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0005856

cytoskeleton

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:2180453
PMID:12040017[88]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:3614372
PMID:16418220[89]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:3629263
PMID:16740478[90]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:3693056
PMID:16962386[91]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:3720546
PMID:17596282[78]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4821939
PMID:17976063[92]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:B4DGU4

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:1331308
PMID:9950951[93]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:2386473
PMID:12181493[94]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:2679904
PMID:14597196[95]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:3826736
PMID:18816447[96]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:3837878
PMID:19151727[97]

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0005912

adherens junction

MGI:MGI:2386380
PMID:12203715[98]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005912

adherens junction

MGI:MGI:2656687
PMID:12695331[37]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005912

adherens junction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:2154851
PMID:11731229[99]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3028451
PMID:14657280[62]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3046012
PMID:15148305[100]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3522322
PMID:15292239[101]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3528104
PMID:15645444[102]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3574751
PMID:15775979[103]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3610287
PMID:16199027[104]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3664674
PMID:16892058[105]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3722560
PMID:17544522[106]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0005915

zonula adherens

MGI:MGI:4459044

PANTHER:PTHR23315

C

From MGI

GO:0005916

fascia adherens

MGI:MGI:3656458
PMID:16481394[107]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005924

cell-substrate adherens junction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0005938

cell cortex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2386811
PMID:12235125[18]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2446944
PMID:12464179[30]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006357

regulation of transcription from RNA polymerase II promoter

MGI:MGI:4430000
PMID:20043884[108]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:3051737
PMID:15131783[109]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0007016

cytoskeletal anchoring at plasma membrane

MGI:MGI:4459044

PANTHER:PTHR23315

P

From MGI

GO:0007155

cell adhesion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0007160

cell-matrix adhesion

MGI:MGI:3051737
PMID:15131783[109]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0007268

synaptic transmission

MGI:MGI:2680876
PMID:14622577[110]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594

P

From MGI

GO:0007398

ectoderm development

MGI:MGI:77405
PMID:8582267[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857678

P

From MGI

GO:0007403

glial cell fate determination

MGI:MGI:3722716
PMID:17706960[111]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007507

heart development

MGI:MGI:2446944
PMID:12464179[30]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148569

P

From MGI

GO:0008022

protein C-terminus binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0008134

transcription factor binding

MGI:MGI:3690195
PMID:16678101[23]

IPI: Inferred from Physical Interaction

MGI:MGI:109330

F

From MGI

GO:0008134

transcription factor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0008283

cell proliferation

MGI:MGI:3051737
PMID:15131783[109]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:4359548
PMID:19690384[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3577106

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0009898

internal side of plasma membrane

MGI:MGI:4459044

PANTHER:PTHR23315

C

From MGI

GO:0009948

anterior/posterior axis specification

MGI:MGI:1353237
PMID:10662781[112]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148590

P

From MGI

GO:0009950

dorsal/ventral axis specification

MGI:MGI:2670493
PMID:12923052[66]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594
MGI:MGI:2158470

P

From MGI

GO:0009953

dorsal/ventral pattern formation

MGI:MGI:3529734
PMID:15708565[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:2176173

P

From MGI

GO:0009954

proximal/distal pattern formation

MGI:MGI:2677587
PMID:12885771[67]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594

P

From MGI

GO:0009987

cellular process

MGI:MGI:2662628
PMID:12717450[113]

IDA: Inferred from Direct Assay

P

From MGI

GO:0010628

positive regulation of gene expression

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0010628

positive regulation of gene expression

MGI:MGI:4359548
PMID:19690384[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3577106

P

From MGI

GO:0010718

positive regulation of epithelial to mesenchymal transition

MGI:MGI:4943617
PMID:20299672[15]

TAS: Traceable Author Statement

P

From MGI

GO:0010909

positive regulation of heparan sulfate proteoglycan biosynthetic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0014010

Schwann cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

P

From MGI

GO:0014010

Schwann cell proliferation

MGI:MGI:4459044

PANTHER:PTHR23315

P

From MGI

GO:0016020

membrane

MGI:MGI:2154850
PMID:11731231[63]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016020

membrane

MGI:MGI:2385552
PMID:12055200[86]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016020

membrane

MGI:MGI:3603077
PMID:15987773[114]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016020

membrane

MGI:MGI:3616720
PMID:16510873[115]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016020

membrane

MGI:MGI:3703395
PMID:16364283[116]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016020

membrane

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

C

From MGI

GO:0016020

membrane

MGI:MGI:81460
PMID:8821035[117]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016055

Wnt receptor signaling pathway

MGI:MGI:2386811
PMID:12235125[18]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016055

Wnt receptor signaling pathway

MGI:MGI:2446944
PMID:12464179[30]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016055

Wnt receptor signaling pathway

MGI:MGI:2662628
PMID:12717450[113]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016055

Wnt receptor signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0016323

basolateral plasma membrane

MGI:MGI:1331308
PMID:9950951[93]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016323

basolateral plasma membrane

MGI:MGI:2677587
PMID:12885771[67]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016323

basolateral plasma membrane

MGI:MGI:2683836
PMID:14625387[118]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016323

basolateral plasma membrane

MGI:MGI:3045643
PMID:15226261[119]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016323

basolateral plasma membrane

MGI:MGI:3719960
PMID:17671182[120]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016323

basolateral plasma membrane

MGI:MGI:4430014
PMID:20016102[121]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016328

lateral plasma membrane

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0016328

lateral plasma membrane

MGI:MGI:3528104
PMID:15645444[102]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016331

morphogenesis of embryonic epithelium

MGI:MGI:3603687
PMID:16102745[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3045749

P

From MGI

GO:0016337

cell-cell adhesion

MGI:MGI:3603687
PMID:16102745[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3045749

P

From MGI

GO:0016337

cell-cell adhesion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

P

From MGI

GO:0016337

cell-cell adhesion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0016342

catenin complex

MGI:MGI:4459044

PANTHER:PTHR23315

C

From MGI

GO:0016342

catenin complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0019899

enzyme binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0019900

kinase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4459044

PANTHER:PTHR23315

F

From MGI

GO:0019903

protein phosphatase binding

MGI:MGI:3689290
PMID:16973135[122]

IPI: Inferred from Physical Interaction

UniProtKB:O14522

F

From MGI

GO:0019903

protein phosphatase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0022009

central nervous system vasculogenesis

MGI:MGI:3821408
PMID:19023080[123]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148569

P

From MGI

GO:0022405

hair cycle process

MGI:MGI:1934694
PMID:11371349[124]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594
MGI:MGI:2148596

P

From MGI

GO:0030018

Z disc

MGI:MGI:81460
PMID:8821035[117]

IDA: Inferred from Direct Assay

C

From MGI

GO:0030027

lamellipodium

MGI:MGI:3028451
PMID:14657280[62]

IDA: Inferred from Direct Assay

C

From MGI

GO:0030054

cell junction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0030057

desmosome

MGI:MGI:4459044

PANTHER:PTHR23315

C

From MGI

GO:0030097

hemopoiesis

MGI:MGI:2662628
PMID:12717450[113]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030154

cell differentiation

MGI:MGI:3051737
PMID:15131783[109]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0030154

cell differentiation

MGI:MGI:3607950
PMID:16192304[125]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148569

P

From MGI

GO:0030217

T cell differentiation

MGI:MGI:2680853
PMID:14608382[126]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594
MGI:MGI:2448686

P

From MGI

GO:0030316

osteoclast differentiation

MGI:MGI:3578468
PMID:15866165[69]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0030324

lung development

MGI:MGI:2677587
PMID:12885771[67]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594

P

From MGI

GO:0030324

lung development

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0030331

estrogen receptor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0030539

male genitalia development

MGI:MGI:3845460
PMID:19282366[127]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594

P

From MGI

GO:0030856

regulation of epithelial cell differentiation

MGI:MGI:2667427
PMID:12813461[128]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0030858

positive regulation of epithelial cell differentiation

MGI:MGI:3613282
PMID:16040629[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008
MGI:MGI:2679524
MGI:MGI:2445707

P

From MGI

GO:0030900

forebrain development

MGI:MGI:3529734
PMID:15708565[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:2176173

P

From MGI

GO:0030902

hindbrain development

MGI:MGI:4459044

PANTHER:PTHR23315

P

From MGI

GO:0030997

regulation of centriole-centriole cohesion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0031016

pancreas development

MGI:MGI:3607950
PMID:16192304[125]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148569

P

From MGI

GO:0031069

hair follicle morphogenesis

MGI:MGI:1934694
PMID:11371349[124]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594
MGI:MGI:2148596

P

From MGI

GO:0031253

cell projection membrane

MGI:MGI:3689461
PMID:16621792[129]

IDA: Inferred from Direct Assay

C

From MGI

GO:0031528

microvillus membrane

MGI:MGI:3617131
PMID:16439479[70]

IDA: Inferred from Direct Assay

C

From MGI

GO:0031641

regulation of myelination

MGI:MGI:3849618
PMID:19515974[130]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0032331

negative regulation of chondrocyte differentiation

MGI:MGI:3701031
PMID:16818445[24]

IGI: Inferred from Genetic Interaction

MGI:MGI:2446084

P

From MGI

GO:0032355

response to estradiol stimulus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0032403

protein complex binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

F

From MGI

GO:0032993

protein-DNA complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0033077

T cell differentiation in thymus

MGI:MGI:3588595
PMID:16025118[131]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0034097

response to cytokine stimulus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

P

From MGI

GO:0034333

adherens junction assembly

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0034394

protein localization at cell surface

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0034613

cellular protein localization

MGI:MGI:3689461
PMID:16621792[129]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0034742

APC-Axin-1-beta-catenin complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0034747

Axin-APC-beta-catenin-GSK3B complex

MGI:MGI:1336856
PMID:10318824[33]

IDA: Inferred from Direct Assay

C

From MGI

GO:0034747

Axin-APC-beta-catenin-GSK3B complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0034750

Scrib-APC-beta-catenin complex

MGI:MGI:4362003
PMID:16611247[53]

IDA: Inferred from Direct Assay

C

From MGI

GO:0035050

embryonic heart tube development

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0035112

genitalia morphogenesis

MGI:MGI:3807613
PMID:18635608[132]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0035116

embryonic hindlimb morphogenesis

MGI:MGI:2670493
PMID:12923052[66]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594
MGI:MGI:2158470

P

From MGI

GO:0035116

embryonic hindlimb morphogenesis

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0035117

embryonic arm morphogenesis

MGI:MGI:3055626
PMID:15371327[68]

IDA: Inferred from Direct Assay

P

From MGI

GO:0035255

ionotropic glutamate receptor binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

F

From MGI

GO:0035257

nuclear hormone receptor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0036023

embryonic skeletal limb joint morphogenesis

MGI:MGI:4950000
PMID:21262216[133]

IGI: Inferred from Genetic Interaction

UniProtKB:Q91ZD1

P

From MGI

GO:0042127

regulation of cell proliferation

MGI:MGI:2386811
PMID:12235125[18]

IDA: Inferred from Direct Assay

P

From MGI

GO:0042127

regulation of cell proliferation

MGI:MGI:3695656
PMID:17055474[134]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0042127

regulation of cell proliferation

MGI:MGI:3807613
PMID:18635608[132]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0042129

regulation of T cell proliferation

MGI:MGI:2680853
PMID:14608382[126]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594
MGI:MGI:2448686

P

From MGI

GO:0042153

RPTP-like protein binding

MGI:MGI:4459044

PANTHER:PTHR23315

F

From MGI

GO:0042475

odontogenesis of dentin-containing tooth

MGI:MGI:3578468
PMID:15866165[69]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0042733

embryonic digit morphogenesis

MGI:MGI:2670493
PMID:12923052[66]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594
MGI:MGI:2158470

P

From MGI

GO:0042733

embryonic digit morphogenesis

MGI:MGI:4430000
PMID:20043884[108]

IGI: Inferred from Genetic Interaction

MGI:MGI:1338938

P

From MGI

GO:0042733

embryonic digit morphogenesis

MGI:MGI:4430000
PMID:20043884[108]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0042981

regulation of apoptotic process

MGI:MGI:4430000
PMID:20043884[108]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:4454604
PMID:20454446[135]

IGI: Inferred from Genetic Interaction

MGI:MGI:98957

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:4454604
PMID:20454446[135]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

MGI:MGI:4355652
PMID:19619491[26]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0043198

dendritic shaft

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

C

From MGI

GO:0043198

dendritic shaft

MGI:MGI:4459044

PANTHER:PTHR23315

C

From MGI

GO:0043234

protein complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

C

From MGI

GO:0043296

apical junction complex

MGI:MGI:3610718
PMID:16249236[136]

IDA: Inferred from Direct Assay

C

From MGI

GO:0043296

apical junction complex

MGI:MGI:3723326
PMID:17666436[137]

IDA: Inferred from Direct Assay

C

From MGI

GO:0043410

positive regulation of MAPK cascade

MGI:MGI:3618985
PMID:16478791[138]

IGI: Inferred from Genetic Interaction

MGI:MGI:88039

P

From MGI

GO:0043588

skin development

MGI:MGI:4412144
PMID:19718027[139]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594

P

From MGI

GO:0043627

response to estrogen stimulus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

P

From MGI

GO:0043627

response to estrogen stimulus

MGI:MGI:4459044

PANTHER:PTHR23315

P

From MGI

GO:0044212

transcription regulatory region DNA binding

MGI:MGI:3820325
PMID:19056892[140]

IDA: Inferred from Direct Assay

F

From MGI

GO:0044212

transcription regulatory region DNA binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0044325

ion channel binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0044334

canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0044336

canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0045177

apical part of cell

MGI:MGI:3033551
PMID:14758363[141]

IDA: Inferred from Direct Assay

C

From MGI

GO:0045177

apical part of cell

MGI:MGI:3037622
PMID:15037549[142]

IDA: Inferred from Direct Assay

C

From MGI

GO:0045177

apical part of cell

MGI:MGI:3610718
PMID:16249236[136]

IDA: Inferred from Direct Assay

C

From MGI

GO:0045202

synapse

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

C

From MGI

GO:0045202

synapse

MGI:MGI:4459044

PANTHER:PTHR23315

C

From MGI

GO:0045294

alpha-catenin binding

MGI:MGI:2447521
PMID:12432063[36]

IPI: Inferred from Physical Interaction

F

From MGI

GO:0045294

alpha-catenin binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0045296

cadherin binding

MGI:MGI:1337175
PMID:10330403[143]

ISO: Inferred from Sequence Orthology

UniProtKB:A1A5I6

F

From MGI

GO:0045296

cadherin binding

MGI:MGI:3051736
PMID:15057752[144]

IPI: Inferred from Physical Interaction

UniProtKB:P09803

F

From MGI

GO:0045296

cadherin binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

F

From MGI

GO:0045296

cadherin binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0045453

bone resorption

MGI:MGI:3578468
PMID:15866165[69]

IGI: Inferred from Genetic Interaction

MGI:MGI:98504

P

From MGI

GO:0045453

bone resorption

MGI:MGI:3578468
PMID:15866165[69]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008
MGI:MGI:2148567
MGI:MGI:3041864

P

From MGI

GO:0045595

regulation of cell differentiation

MGI:MGI:2662628
PMID:12717450[113]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045596

negative regulation of cell differentiation

MGI:MGI:3578464
PMID:15866163[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148591
MGI:MGI:2148594
MGI:MGI:2450929

P

From MGI

GO:0045596

negative regulation of cell differentiation

MGI:MGI:3603687
PMID:16102745[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3045749

P

From MGI

GO:0045603

positive regulation of endothelial cell differentiation

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0045667

regulation of osteoblast differentiation

MGI:MGI:3511731
PMID:15576404[145]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3044412

P

From MGI

GO:0045667

regulation of osteoblast differentiation

MGI:MGI:3584206
PMID:15802266[146]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0045669

positive regulation of osteoblast differentiation

MGI:MGI:3578464
PMID:15866163[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148591
MGI:MGI:2148594
MGI:MGI:2450929

P

From MGI

GO:0045670

regulation of osteoclast differentiation

MGI:MGI:3584206
PMID:15802266[146]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0045671

negative regulation of osteoclast differentiation

MGI:MGI:3578468
PMID:15866165[69]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3041864

P

From MGI

GO:0045743

positive regulation of fibroblast growth factor receptor signaling pathway

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0045743

positive regulation of fibroblast growth factor receptor signaling pathway

MGI:MGI:3801531
PMID:18533146[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0045768

positive regulation of anti-apoptosis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:2655026
PMID:12551949[147]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:3578464
PMID:15866163[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:1351293
PMID:10631168[148]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:1351293
PMID:10631168[148]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:2655026
PMID:12551949[147]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:2675528
PMID:12949260[31]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3578464
PMID:15866163[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3656361
PMID:16936075[73]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3656361
PMID:16936075[73]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3759355
PMID:17767158[25]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3820325
PMID:19056892[140]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3822373
PMID:19112489[149]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4359548
PMID:19690384[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3577106

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3038034
PMID:15024079[19]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3054506
PMID:15314168[150]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3530428
PMID:15729346[151]

IGI: Inferred from Genetic Interaction

MGI:MGI:97487
MGI:MGI:98358
MGI:MGI:104554

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3579620
PMID:15778706[20]

IGI: Inferred from Genetic Interaction

MGI:MGI:1202879

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3582095
PMID:15907834[21]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3690195
PMID:16678101[23]

IGI: Inferred from Genetic Interaction

MGI:MGI:109330

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4438134
PMID:19620969[16]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4439199
PMID:20159597[28]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4459044

PANTHER:PTHR23315

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0046332

SMAD binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0048469

cell maturation

MGI:MGI:3511731
PMID:15576404[145]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3044412

P

From MGI

GO:0048469

cell maturation

MGI:MGI:3722716
PMID:17706960[111]

IDA: Inferred from Direct Assay

P

From MGI

GO:0048471

perinuclear region of cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0048489

synaptic vesicle transport

MGI:MGI:2680876
PMID:14622577[110]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594

P

From MGI

GO:0048513

organ development

MGI:MGI:3807613
PMID:18635608[132]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0048538

thymus development

MGI:MGI:3588595
PMID:16025118[131]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0048599

oocyte development

MGI:MGI:4454604
PMID:20454446[135]

IGI: Inferred from Genetic Interaction

MGI:MGI:98957

P

From MGI

GO:0048617

embryonic foregut morphogenesis

MGI:MGI:3820452
PMID:18692041[152]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0048660

regulation of smooth muscle cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0048715

negative regulation of oligodendrocyte differentiation

MGI:MGI:4359141
PMID:19503085[52]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0050808

synapse organization

MGI:MGI:2680876
PMID:14622577[110]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594

P

From MGI

GO:0051145

smooth muscle cell differentiation

MGI:MGI:4359548
PMID:19690384[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3577106

P

From MGI

GO:0051291

protein heterooligomerization

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

P

From MGI

GO:0060038

cardiac muscle cell proliferation

MGI:MGI:4943617
PMID:20299672[15]

TAS: Traceable Author Statement

P

From MGI

GO:0060066

oviduct development

MGI:MGI:3716048
PMID:17532316[153]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3042214
MGI:MGI:2148567

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:3577701
PMID:15781477[44]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:3690195
PMID:16678101[23]

IGI: Inferred from Genetic Interaction

MGI:MGI:109330

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:3701031
PMID:16818445[24]

IGI: Inferred from Genetic Interaction

MGI:MGI:2446084

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:3821953
PMID:19060336[17]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:4355652
PMID:19619491[26]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:4359548
PMID:19690384[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567
MGI:MGI:3577106

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:4360856
PMID:19686689[154]

IGI: Inferred from Genetic Interaction

MGI:MGI:98954
MGI:MGI:1261834

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:4454604
PMID:20454446[135]

IGI: Inferred from Genetic Interaction

MGI:MGI:98957

P

From MGI

GO:0060070

canonical Wnt receptor signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0060173

limb development

MGI:MGI:2450015
PMID:12569130[155]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0060439

trachea morphogenesis

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0060439

trachea morphogenesis

MGI:MGI:3820452
PMID:18692041[152]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0060440

trachea formation

MGI:MGI:4361775
PMID:19805295[156]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148569

P

From MGI

GO:0060441

epithelial tube branching involved in lung morphogenesis

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0060479

lung cell differentiation

MGI:MGI:4361775
PMID:19805295[156]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148569

P

From MGI

GO:0060484

lung-associated mesenchyme development

MGI:MGI:3801531
PMID:18533146[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0060485

mesenchyme development

MGI:MGI:4943617
PMID:20299672[15]

TAS: Traceable Author Statement

P

From MGI

GO:0060492

lung induction

MGI:MGI:4360856
PMID:19686689[154]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0060492

lung induction

MGI:MGI:4361775
PMID:19805295[156]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148569

P

From MGI

GO:0060742

epithelial cell differentiation involved in prostate gland development

MGI:MGI:2667427
PMID:12813461[128]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0060769

positive regulation of epithelial cell proliferation involved in prostate gland development

MGI:MGI:2667427
PMID:12813461[128]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0060789

hair follicle placode formation

MGI:MGI:1934694
PMID:11371349[124]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148594
MGI:MGI:2148596

P

From MGI

GO:0060789

hair follicle placode formation

MGI:MGI:4355652
PMID:19619491[26]

IGI: Inferred from Genetic Interaction

MGI:MGI:1195272

P

From MGI

GO:0060916

mesenchymal cell proliferation involved in lung development

MGI:MGI:3696593
PMID:17128274[75]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0060916

mesenchymal cell proliferation involved in lung development

MGI:MGI:3773938
PMID:18231602[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0060947

cardiac vascular smooth muscle cell differentiation

MGI:MGI:4943617
PMID:20299672[15]

TAS: Traceable Author Statement

P

From MGI

GO:0060982

coronary artery morphogenesis

MGI:MGI:4943617
PMID:20299672[15]

TAS: Traceable Author Statement

P

From MGI

GO:0060983

epicardium-derived cardiac vascular smooth muscle cell differentiation

MGI:MGI:4943617
PMID:20299672[15]

TAS: Traceable Author Statement

P

From MGI

GO:0061047

positive regulation of branching involved in lung morphogenesis

MGI:MGI:3801531
PMID:18533146[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2148567

P

From MGI

GO:0061154

endothelial tube morphogenesis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0061198

fungiform papilla formation

MGI:MGI:3696593
PMID:17128274[75]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0061324

canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation

MGI:MGI:2446944
PMID:12464179[30]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0070369

beta-catenin-TCF7L2 complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0070411

I-SMAD binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0070412

R-SMAD binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

F

From MGI

GO:0070491

repressing transcription factor binding

MGI:MGI:3709704
PMID:17331723[157]

IPI: Inferred from Physical Interaction

UniProtKB:P10071

F

From MGI

GO:0070602

regulation of centromeric sister chromatid cohesion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0070602

regulation of centromeric sister chromatid cohesion

MGI:MGI:4835108
PMID:20300119[85]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0071363

cellular response to growth factor stimulus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0071407

cellular response to organic cyclic compound

MGI:MGI:2385552
PMID:12055200[86]

IDA: Inferred from Direct Assay

P

From MGI

GO:0071681

cellular response to indole-3-methanol

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:0071944

cell periphery

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

C

From MGI

GO:0072001

renal system development

MGI:MGI:3807613
PMID:18635608[132]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0072033

renal vesicle formation

MGI:MGI:3714576
PMID:17537789[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0072053

renal inner medulla development

MGI:MGI:3821953
PMID:19060336[17]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0072054

renal outer medulla development

MGI:MGI:3821953
PMID:19060336[17]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0072079

nephron tubule formation

MGI:MGI:3714576
PMID:17537789[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1858008

P

From MGI

GO:0072132

mesenchyme morphogenesis

MGI:MGI:4943617
PMID:20299672[15]

TAS: Traceable Author Statement

P

From MGI

GO:0072182

regulation of nephron tubule epithelial cell differentiation

MGI:MGI:3822373
PMID:19112489[149]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0090279

regulation of calcium ion import

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:2000008

regulation of protein localization at cell surface

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P35222

P

From MGI

GO:2000017

positive regulation of determination of dorsal identity

MGI:MGI:3797993
PMID:18316368[158]

IDA: Inferred from Direct Assay

P

From MGI

colocalizes_with

GO:0043005

neuron projection

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445809

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 Mucenski ML et al. (2005) Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol 289: L971-9 PubMed GONUTS page
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  3. ↑ 3.0 3.1 3.2 3.3 3.4 Smith AN et al. (2005) The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol 285: 477-89 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Hill TP et al. (2005) Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8: 727-38 PubMed GONUTS page
  5. ↑ Cattelino A et al. (2003) The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol 162: 1111-22 PubMed GONUTS page
  6. ↑ Phng LK et al. (2009) Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell 16: 70-82 PubMed GONUTS page
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 De Langhe SP et al. (2008) Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One 3: e1516 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Park JS et al. (2007) Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development 134: 2533-9 PubMed GONUTS page
  9. ↑ Chia IV et al. (2009) Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis. Genetics 181: 1359-68 PubMed GONUTS page
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  11. ↑ 11.0 11.1 Lickert H et al. (2002) Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm. Dev Cell 3: 171-81 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Backman M et al. (2005) Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol 279: 155-68 PubMed GONUTS page
  13. ↑ 13.0 13.1 Buchman JJ et al. (2011) ASPM regulates Wnt signaling pathway activity in the developing brain. Genes Dev 25: 1909-14 PubMed GONUTS page
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  22. ↑ Si W et al. (2006) CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol 26: 2955-64 PubMed GONUTS page
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  25. ↑ 25.0 25.1 Zhou W et al. (2007) Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet 39: 1225-34 PubMed GONUTS page
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