MGI:Ctgf

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001502	cartilage condensation	MGI:MGI:3050271 PMID:15305294^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001503	ossification	MGI:MGI:1931624 PMID:11237711^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001503	ossification	MGI:MGI:2660724 PMID:12736220^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2663631	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:1333654 PMID:10082563^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:1342849 PMID:10446209^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:2660724 PMID:12736220^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2663631	P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0001968	fibronectin binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	F	From MGI
	GO:0005178	integrin binding	MGI:MGI:1342849 PMID:10446209^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005576	extracellular region	MGI:MGI:59843 PMID:1888698^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005578	proteinaceous extracellular matrix	MGI:MGI:707922 PMID:9184077^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	C	From MGI
	GO:0005794	Golgi apparatus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29279	C	From MGI
	GO:0005801	cis-Golgi network	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	C	From MGI
	GO:0005938	cell cortex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	C	From MGI
	GO:0007160	cell-matrix adhesion	MGI:MGI:707922 PMID:9184077^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007229	integrin-mediated signaling pathway	MGI:MGI:1333654 PMID:10082563^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007229	integrin-mediated signaling pathway	MGI:MGI:1342849 PMID:10446209^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	F	From MGI
	GO:0008201	heparin binding	MGI:MGI:707922 PMID:9184077^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0008543	fibroblast growth factor receptor signaling pathway	MGI:MGI:707922 PMID:9184077^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0010942	positive regulation of cell death	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0016477	cell migration	MGI:MGI:1333654 PMID:10082563^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:3050271 PMID:15305294^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030324	lung development	MGI:MGI:3771125 PMID:18213577^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2663631	P	From MGI
	GO:0032967	positive regulation of collagen biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0035556	intracellular signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0043231	intracellular membrane-bounded organelle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29279	C	From MGI
	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0045597	positive regulation of cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29279	P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29279	P	From MGI
	GO:0048471	perinuclear region of cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	C	From MGI
	GO:0050867	positive regulation of cell activation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0051496	positive regulation of stress fiber assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29279	P	From MGI
	GO:0060401	cytosolic calcium ion transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0060452	positive regulation of cardiac muscle contraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0070278	extracellular matrix constituent secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0070318	positive regulation of G0 to G1 transition	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_071602	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29279	P	From MGI
	GO:0072593	reactive oxygen species metabolic process	MGI:MGI:3849354 PMID:19364818^[9]	IDA: Inferred from Direct Assay		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Shimo T et al. (2004) Expression and roles of connective tissue growth factor in Meckel's cartilage development. Dev Dyn 231: 136-47 PubMed GONUTS page
↑ Nakanishi T et al. (2001) Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. Biochem Biophys Res Commun 281: 678-81 PubMed GONUTS page
↑ ^3.0 ^3.1 Ivkovic S et al. (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130: 2779-91 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Babic AM et al. (1999) Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol 19: 2958-66 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Jedsadayanmata A et al. (1999) Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3). J Biol Chem 274: 24321-7 PubMed GONUTS page
↑ Ryseck RP et al. (1991) Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ 2: 225-33 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Kireeva ML et al. (1997) Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. Exp Cell Res 233: 63-77 PubMed GONUTS page
↑ Baguma-Nibasheka M & Kablar B (2008) Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse. Dev Dyn 237: 485-93 PubMed GONUTS page
↑ Juric V et al. (2009) Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol Cell Biol 29: 3266-79 PubMed GONUTS page

[PMID:15305294-0] 1.0 ^1.1 Shimo T et al. (2004) Expression and roles of connective tissue growth factor in Meckel's cartilage development. Dev Dyn 231: 136-47 PubMed GONUTS page

[PMID:11237711-1] Nakanishi T et al. (2001) Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. Biochem Biophys Res Commun 281: 678-81 PubMed GONUTS page

[PMID:12736220-2] 3.0 ^3.1 Ivkovic S et al. (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130: 2779-91 PubMed GONUTS page

[PMID:10082563-3] 4.0 ^4.1 ^4.2 Babic AM et al. (1999) Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol 19: 2958-66 PubMed GONUTS page

[PMID:10446209-4] 5.0 ^5.1 ^5.2 Jedsadayanmata A et al. (1999) Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3). J Biol Chem 274: 24321-7 PubMed GONUTS page

[PMID:1888698-5] Ryseck RP et al. (1991) Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ 2: 225-33 PubMed GONUTS page

[PMID:9184077-6] 7.0 ^7.1 ^7.2 ^7.3 Kireeva ML et al. (1997) Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. Exp Cell Res 233: 63-77 PubMed GONUTS page

[PMID:18213577-7] Baguma-Nibasheka M & Kablar B (2008) Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse. Dev Dyn 237: 485-93 PubMed GONUTS page

[PMID:19364818-8] Juric V et al. (2009) Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol Cell Biol 29: 3266-79 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Ctgf ( synonyms: Ccn2, Fisp12, Hcs24, hypertrophic chondrocyte-specific gene product 24 )
Protein Name(s)	connective tissue growth factor,
External Links
MGI	MGI:95537

MGI:Ctgf

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