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MGI:Ctcf
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ctcf | |
| Protein Name(s) | CCCTC-binding factor, | |
| External Links | ||
| MGI | MGI:109447 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000775 |
chromosome, centromeric region |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2156936 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2450195 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3045676 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3054495 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3663239 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3574013 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3655751 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005654 |
nucleoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005694 |
chromosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0158 |
C |
From MGI |
||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006306 |
DNA methylation |
MGI:MGI:2450195 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006349 |
regulation of gene expression by genetic imprinting |
MGI:MGI:2450195 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006349 |
regulation of gene expression by genetic imprinting |
MGI:MGI:3044090 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006349 |
regulation of gene expression by genetic imprinting |
MGI:MGI:3045676 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:3045676 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007059 |
chromosome segregation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0159 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0009048 |
dosage compensation by inactivation of X chromosome |
MGI:MGI:2156936 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0010216 |
maintenance of DNA methylation |
MGI:MGI:3044090 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:3852297 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:3852297 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016568 |
chromatin modification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0156 |
P |
From MGI |
||
| GO:0016584 |
nucleosome positioning |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031060 |
regulation of histone methylation |
MGI:MGI:3655597 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035065 |
regulation of histone acetylation |
MGI:MGI:3655597 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0040029 |
regulation of gene expression, epigenetic |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0040030 |
regulation of molecular function, epigenetic |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043035 |
chromatin insulator sequence binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Chao W et al. (2002) CTCF, a candidate trans-acting factor for X-inactivation choice. Science 295: 345-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Schoenherr CJ et al. (2003) CTCF maintains differential methylation at the Igf2/H19 locus. Nat Genet 33: 66-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Szabó PE et al. (2004) Role of CTCF binding sites in the Igf2/H19 imprinting control region. Mol Cell Biol 24: 4791-800 PubMed GONUTS page
- ↑ Thakur N et al. (2004) An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region. Mol Cell Biol 24: 7855-62 PubMed GONUTS page
- ↑ Ishihara K et al. (2006) CTCF-dependent chromatin insulator is linked to epigenetic remodeling. Mol Cell 23: 733-42 PubMed GONUTS page
- ↑ Korn C et al. (2005) Interaction of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism for nuclease inhibition and suggests that DFF can be activated in a DNA-bound state. J Biol Chem 280: 6005-15 PubMed GONUTS page
- ↑ Loukinov DI et al. (2002) BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A 99: 6806-11 PubMed GONUTS page
- ↑ 8.0 8.1 Fedoriw AM et al. (2004) Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting. Science 303: 238-40 PubMed GONUTS page
- ↑ 9.0 9.1 Wan LB et al. (2008) Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development 135: 2729-38 PubMed GONUTS page
- ↑ 10.0 10.1 Splinter E et al. (2006) CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev 20: 2349-54 PubMed GONUTS page
