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MGI:Ctbp2

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ctbp2 ( synonyms: D7Ertd45e, Gtrgeo6, Ribeye )
Protein Name(s) C-terminal binding protein 2,
External Links
MGI MGI:1201686

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR016040

F

From MGI

GO:0003714

transcription corepressor activity

MGI:MGI:1349212
PMID:10567582[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003714

transcription corepressor activity

MGI:MGI:2446766
PMID:12444977[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Z2Z2
UniProtKB:Q925H1
UniProtKB:O03267

F

From MGI

GO:0005515

protein binding

MGI:MGI:1342875
PMID:10438528[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q8WW38

F

From MGI

GO:0005515

protein binding

MGI:MGI:2446766
PMID:12444977[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q925H1

F

From MGI

GO:0005515

protein binding

MGI:MGI:3688378
PMID:14736873[4]

IPI: Inferred from Physical Interaction

UniProtKB:P48552

F

From MGI

GO:0005515

protein binding

MGI:MGI:3689671
PMID:16940172[5]

IPI: Inferred from Physical Interaction

UniProtKB:O75362

F

From MGI

GO:0005515

protein binding

MGI:MGI:4418632
PMID:11328817[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q03112

F

From MGI

GO:0005515

protein binding

MGI:MGI:4839443
PMID:17635584[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q03112

F

From MGI

GO:0005515

protein binding

MGI:MGI:5009348
PMID:20705609[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q8CCH7

F

From MGI

GO:0005515

protein binding

MGI:MGI:5306305
PMID:16762039[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q14526

F

From MGI

GO:0005634

nucleus

MGI:MGI:4365360
PMID:18483224[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From MGI

GO:0008152

metabolic process

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006139

P

From MGI

GO:0016491

oxidoreductase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

From MGI

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006139
InterPro:IPR006140

F

From MGI

GO:0017053

transcriptional repressor complex

MGI:MGI:4365360
PMID:18483224[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0030054

cell junction

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0965

C

From MGI

GO:0030154

cell differentiation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

From MGI

GO:0045202

synapse

MGI:MGI:4460838
PMID:20368623[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:2446766
PMID:12444977[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Z2Z2
UniProtKB:Q925H1
UniProtKB:O03267

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:4365360
PMID:18483224[10]

IDA: Inferred from Direct Assay

P

From MGI

GO:0048037

cofactor binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006140

F

From MGI

GO:0050872

white fat cell differentiation

MGI:MGI:4365360
PMID:18483224[10]

IDA: Inferred from Direct Assay

P

From MGI

GO:0051287

NAD binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006139

F

From MGI

GO:0055114

oxidation-reduction process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

P

From MGI

GO:0055114

oxidation-reduction process

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006139
InterPro:IPR006140

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Furusawa T et al. (1999) Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. Mol Cell Biol 19: 8581-90 PubMed GONUTS page
  2. 2.0 2.1 2.2 Perdomo J & Crossley M (2002) The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. Eur J Biochem 269: 5885-92 PubMed GONUTS page
  3. Holmes M et al. (1999) hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. J Biol Chem 274: 23491-8 PubMed GONUTS page
  4. Christian M et al. (2004) Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. J Biol Chem 279: 15645-51 PubMed GONUTS page
  5. Quinlan KG et al. (2006) Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. Mol Cell Biol 26: 8159-72 PubMed GONUTS page
  6. Palmer S et al. (2001) Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins. J Biol Chem 276: 25834-40 PubMed GONUTS page
  7. McGilvray R et al. (2007) UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation. FEBS J 274: 3960-71 PubMed GONUTS page
  8. Jack BH & Crossley M (2010) GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis. J Biol Chem 285: 32405-14 PubMed GONUTS page
  9. Stankovic-Valentin N et al. (2006) A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. FEBS J 273: 2879-90 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Kajimura S et al. (2008) Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev 22: 1397-409 PubMed GONUTS page
  11. Sedmak T & Wolfrum U (2010) Intraflagellar transport molecules in ciliary and nonciliary cells of the retina. J Cell Biol 189: 171-86 PubMed GONUTS page
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