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MGI:Csk

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Csk
Protein Name(s) c-src tyrosine kinase,
External Links
MGI MGI:88537

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From MGI

GO:0004672

protein kinase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245

F

From MGI

GO:0004713

protein tyrosine kinase activity

MGI:MGI:3687921
PMID:12612075[1]

TAS: Traceable Author Statement

F

From MGI

GO:0004713

protein tyrosine kinase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

F

From MGI

GO:0004715

non-membrane spanning protein tyrosine kinase activity

MGI:MGI:2152096

IEA: Inferred from Electronic Annotation

EC:2.7.10.2

F

From MGI

GO:0005515

protein binding

MGI:MGI:3687921
PMID:12612075[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q3U1F9

F

From MGI

GO:0005524

ATP binding

MGI:MGI:3687921
PMID:12612075[1]

TAS: Traceable Author Statement

F

From MGI

GO:0005622

intracellular

MGI:MGI:3687921
PMID:12612075[1]

TAS: Traceable Author Statement

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:E7EQW6

C

From MGI

GO:0005794

Golgi apparatus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:E7EQW6

C

From MGI

GO:0005813

centrosome

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:E7EQW6

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:3687921
PMID:12612075[1]

TAS: Traceable Author Statement

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P41240

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:3577866
PMID:15861137[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:2152096

IEA: Inferred from Electronic Annotation

EC:2.7.10.2

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:3687921
PMID:12612075[1]

TAS: Traceable Author Statement

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3577866
PMID:15861137[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:105057

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3577866
PMID:15861137[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0010989

negative regulation of low-density lipoprotein particle clearance

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016301

kinase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

From MGI

GO:0016310

phosphorylation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

From MGI

GO:0016740

transferase activity

MGI:MGI:3687921
PMID:12612075[1]

TAS: Traceable Author Statement

F

From MGI

GO:0016772

transferase activity, transferring phosphorus-containing groups

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

From MGI

GO:0019903

protein phosphatase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

F

From MGI

GO:0032715

negative regulation of interleukin-6 production

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0033673

negative regulation of kinase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0035556

intracellular signal transduction

MGI:MGI:3687921
PMID:12612075[1]

TAS: Traceable Author Statement

P

From MGI

GO:0043231

intracellular membrane-bounded organelle

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:E7EQW6

C

From MGI

GO:0043406

positive regulation of MAP kinase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0045121

membrane raft

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

C

From MGI

GO:0045779

negative regulation of bone resorption

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0046777

protein autophosphorylation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0050765

negative regulation of phagocytosis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0050863

regulation of T cell activation

MGI:MGI:3687921
PMID:12612075[1]

TAS: Traceable Author Statement

P

From MGI

GO:0060368

regulation of Fc receptor mediated stimulatory signaling pathway

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0070064

proline-rich region binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

F

From MGI

GO:0070373

negative regulation of ERK1 and ERK2 cascade

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI

GO:0071375

cellular response to peptide hormone stimulus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P32577

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Davidson D et al. (2003) Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor. Mol Cell Biol 23: 2017-28 PubMed GONUTS page
  2. 2.0 2.1 2.2 Baumeister U et al. (2005) Association of Csk to VE-cadherin and inhibition of cell proliferation. EMBO J 24: 1686-95 PubMed GONUTS page
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