MGI:Csf1r

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0829	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008266 InterPro:IPR020635	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016243 InterPro:IPR001824	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0005011	macrophage colony-stimulating factor receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	F	From MGI
	GO:0005011	macrophage colony-stimulating factor receptor activity	MGI:MGI:5294320 PMID:8007983^[1]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0005515	protein binding	MGI:MGI:2653734 PMID:12540842^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q8R0L1	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441 InterPro:IPR016243 InterPro:IPR001824	F	From MGI
	GO:0005622	intracellular	MGI:MGI:5294513 PMID:21610095^[3]	IMP: Inferred from Mutant Phenotype		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:3576987 PMID:15860730^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635 InterPro:IPR016243 InterPro:IPR001824	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0395	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016243 InterPro:IPR001824	P	From MGI
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	MGI:MGI:5294321 PMID:8262059^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008283	cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q00495	P	From MGI
	GO:0008283	cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:5294320 PMID:8007983^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008360	regulation of cell shape	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0008360	regulation of cell shape	MGI:MGI:5294513 PMID:21610095^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0009986	cell surface	MGI:MGI:5294320 PMID:8007983^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016020	membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001824	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016243	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:5294320 PMID:8007983^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019221	cytokine-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0019955	cytokine binding	MGI:MGI:3836228 PMID:19017797^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P07141	F	From MGI
	GO:0019955	cytokine binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	F	From MGI
	GO:0019955	cytokine binding	MGI:MGI:5294320 PMID:8007983^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0030097	hemopoiesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0030316	osteoclast differentiation	MGI:MGI:4835629 PMID:20504948^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030316	osteoclast differentiation	MGI:MGI:5294299 PMID:17121910^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030316	osteoclast differentiation	MGI:MGI:5294540 PMID:18814279^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:5294513 PMID:21610095^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0031529	ruffle organization	MGI:MGI:5294513 PMID:21610095^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	MGI:MGI:5294320 PMID:8007983^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	[[Category:]]GO:0038145		MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	[[Category:]]GO:0038145		MGI:MGI:5294320 PMID:8007983^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	MGI:MGI:5294320 PMID:8007983^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:3836228 PMID:19017797^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P09581	F	From MGI
	GO:0043235	receptor complex	MGI:MGI:3836228 PMID:19017797^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0045087	innate immune response	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0399	P	From MGI
	GO:0045124	regulation of bone resorption	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q00495	P	From MGI
	GO:0045217	cell-cell junction maintenance	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0045672	positive regulation of osteoclast differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q00495	P	From MGI
	GO:0046488	phosphatidylinositol metabolic process	MGI:MGI:5294513 PMID:21610095^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4835629 PMID:20504948^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:5294320 PMID:8007983^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048015	phosphatidylinositol-mediated signaling	MGI:MGI:5294513 PMID:21610095^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0061098	positive regulation of protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:5294320 PMID:8007983^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071345	cellular response to cytokine stimulus	MGI:MGI:4835629 PMID:20504948^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071902	positive regulation of protein serine/threonine kinase activity	MGI:MGI:5294513 PMID:21610095^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0090197	positive regulation of chemokine secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:2000147	positive regulation of cell motility	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07333	P	From MGI
	GO:2000249	regulation of actin cytoskeleton reorganization	MGI:MGI:5294513 PMID:21610095^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Myles GM et al. (1994) Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalization. Mol Cell Biol 14: 4843-54 PubMed GONUTS page
↑ Minoguchi M et al. (2003) STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. J Biol Chem 278: 11182-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Sampaio NG et al. (2011) Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion. J Cell Sci 124: 2021-31 PubMed GONUTS page
↑ Pixley FJ et al. (2005) BCL6 suppresses RhoA activity to alter macrophage morphology and motility. J Cell Sci 118: 1873-83 PubMed GONUTS page
↑ van der Geer P & Hunter T (1993) Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts. EMBO J 12: 5161-72 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Chen X et al. (2008) Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases. Proc Natl Acad Sci U S A 105: 18267-72 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Wei S et al. (2010) Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol 88: 495-505 PubMed GONUTS page
↑ Ohno H et al. (2006) A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther 5: 2634-43 PubMed GONUTS page
↑ Hiraga T & Nakamura H (2009) Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals. Int J Cancer 124: 215-22 PubMed GONUTS page

[PMID:8007983-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Myles GM et al. (1994) Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalization. Mol Cell Biol 14: 4843-54 PubMed GONUTS page

[PMID:12540842-1] Minoguchi M et al. (2003) STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. J Biol Chem 278: 11182-9 PubMed GONUTS page

[PMID:21610095-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Sampaio NG et al. (2011) Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion. J Cell Sci 124: 2021-31 PubMed GONUTS page

[PMID:15860730-3] Pixley FJ et al. (2005) BCL6 suppresses RhoA activity to alter macrophage morphology and motility. J Cell Sci 118: 1873-83 PubMed GONUTS page

[PMID:8262059-4] van der Geer P & Hunter T (1993) Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts. EMBO J 12: 5161-72 PubMed GONUTS page

[PMID:19017797-5] 6.0 ^6.1 ^6.2 Chen X et al. (2008) Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases. Proc Natl Acad Sci U S A 105: 18267-72 PubMed GONUTS page

[PMID:20504948-6] 7.0 ^7.1 ^7.2 Wei S et al. (2010) Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol 88: 495-505 PubMed GONUTS page

[PMID:17121910-7] Ohno H et al. (2006) A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther 5: 2634-43 PubMed GONUTS page

[PMID:18814279-8] Hiraga T & Nakamura H (2009) Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals. Int J Cancer 124: 215-22 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Csf1r ( synonyms: CD115, CSF-1R, Csfmr, Fim-2, Fms, M-CSFR )
Protein Name(s)	colony stimulating factor 1 receptor,
External Links
MGI	MGI:1339758

MGI:Csf1r

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