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MGI:Csf1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Csf1 ( synonyms: colony-stimulating factor-1, CSF-1, Csfm, M-CSF ) | |
| Protein Name(s) | colony stimulating factor 1 (macrophage), | |
| External Links | ||
| MGI | MGI:1339753 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001503 |
ossification |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_076471 |
P |
From MGI |
||
| GO:0001954 |
positive regulation of cell-matrix adhesion |
MGI:MGI:3689489 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0003006 |
developmental process involved in reproduction |
MGI:MGI:3614922 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005157 |
macrophage colony-stimulating factor receptor binding |
MGI:MGI:3836228 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3696626 |
IPI: Inferred from Physical Interaction |
UniProtKB:P05480 |
F |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006954 |
inflammatory response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0395 |
P |
From MGI |
||
| GO:0008083 |
growth factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008283 |
cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_076471 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010744 |
positive regulation of macrophage derived foam cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0030225 |
macrophage differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_076471 |
P |
From MGI |
||
| GO:0030278 |
regulation of ossification |
MGI:MGI:2670279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856333 |
P |
From MGI |
||
| GO:0030316 |
osteoclast differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_076471 |
P |
From MGI |
||
| GO:0030316 |
osteoclast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:3689489 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0032270 |
positive regulation of cellular protein metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032946 |
positive regulation of mononuclear cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:2670279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856333 |
P |
From MGI |
||
| GO:0042476 |
odontogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_076471 |
P |
From MGI |
||
| GO:0042488 |
positive regulation of odontogenesis of dentin-containing tooth |
MGI:MGI:2670279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856333 |
P |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:3836228 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_076471 |
F |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043235 |
receptor complex |
MGI:MGI:3836228 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0399 |
P |
From MGI |
||
| GO:0045651 |
positive regulation of macrophage differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045651 |
positive regulation of macrophage differentiation |
MGI:MGI:893319 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856333 |
P |
From MGI |
||
| GO:0045657 |
positive regulation of monocyte differentiation |
MGI:MGI:893319 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856333 |
P |
From MGI |
||
| GO:0045672 |
positive regulation of osteoclast differentiation |
MGI:MGI:3528531 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045672 |
positive regulation of osteoclast differentiation |
MGI:MGI:3689489 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1100089 |
P |
From MGI |
||
| GO:0045672 |
positive regulation of osteoclast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045672 |
positive regulation of osteoclast differentiation |
MGI:MGI:893319 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856333 |
P |
From MGI |
||
| GO:0045860 |
positive regulation of protein kinase activity |
MGI:MGI:3689489 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0046579 |
positive regulation of Ras protein signal transduction |
MGI:MGI:3689489 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048873 |
homeostasis of number of cells within a tissue |
MGI:MGI:893319 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856333 |
P |
From MGI |
||
| GO:0060444 |
branching involved in mammary gland duct morphogenesis |
MGI:MGI:3640884 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856333 |
P |
From MGI |
||
| GO:0060611 |
mammary gland fat development |
MGI:MGI:3640884 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856333 |
P |
From MGI |
||
| GO:0060763 |
mammary duct terminal end bud growth |
MGI:MGI:3640884 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856333 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Yang FC et al. (2006) Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions. J Clin Invest 116: 2880-91 PubMed GONUTS page
- ↑ Ovadia S et al. (2006) The cell-surface isoform of colony stimulating factor 1 (CSF1) restores but does not completely normalize fecundity in CSF1-deficient mice. Biol Reprod 74: 331-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Chen X et al. (2008) Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases. Proc Natl Acad Sci U S A 105: 18267-72 PubMed GONUTS page
- ↑ Cross M et al. (2005) A proteomics strategy for the enrichment of receptor-associated complexes. Proteomics 5: 4754-63 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Yao GQ et al. (2003) The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo. Endocrinology 144: 3677-82 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Lagasse E & Weissman IL (1997) Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Cell 89: 1021-31 PubMed GONUTS page
- ↑ Subramaniam M et al. (2005) TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol 25: 1191-9 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Gouon-Evans V et al. (2000) Postnatal mammary gland development requires macrophages and eosinophils. Development 127: 2269-82 PubMed GONUTS page
