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MGI:Cryab
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cryab ( synonyms: alpha B-crystallin, Crya-2, Crya2, HspB5 ) | |
| Protein Name(s) | crystallin, alpha B, | |
| External Links | ||
| MGI | MGI:88516 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001666 |
response to hypoxia |
MGI:MGI:3776170 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652177 |
P |
From MGI |
||
| GO:0002088 |
lens development in camera-type eye |
MGI:MGI:3617146 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88515 |
P |
From MGI |
||
| GO:0005212 |
structural constituent of eye lens |
MGI:MGI:2682441 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3775669 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:3028713 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005626 |
insoluble fraction |
MGI:MGI:3028713 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3776170 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:3776170 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3028713 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006006 |
glucose metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006457 |
protein folding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007021 |
tubulin complex assembly |
MGI:MGI:3653522 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652177 |
P |
From MGI |
||
| GO:0007517 |
muscle organ development |
MGI:MGI:2154007 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916503 |
P |
From MGI |
||
| GO:0008017 |
microtubule binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008092 |
cytoskeletal protein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:3758141 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652177 |
P |
From MGI |
||
| GO:0015630 |
microtubule cytoskeleton |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030018 |
Z disc |
MGI:MGI:3028713 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031109 |
microtubule polymerization or depolymerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031674 |
I band |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032387 |
negative regulation of intracellular transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032432 |
actin filament bundle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042542 |
response to hydrogen peroxide |
MGI:MGI:3710733 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652177 |
P |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043010 |
camera-type eye development |
MGI:MGI:2682441 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88515 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3776170 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652177 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:3617146 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88515 |
P |
From MGI |
||
| GO:0043292 |
contractile fiber |
MGI:MGI:3028713 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0051082 |
unfolded protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051260 |
protein homooligomerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051403 |
stress-activated MAPK cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060561 |
apoptotic process involved in morphogenesis |
MGI:MGI:3617146 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88515 |
P |
From MGI |
||
| GO:2000378 |
negative regulation of reactive oxygen species metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Yaung J et al. (2008) Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp Eye Res 86: 355-65 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Morozov V & Wawrousek EF (2006) Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice. Development 133: 813-21 PubMed GONUTS page
- ↑ 3.0 3.1 Boyle DL et al. (2003) Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. BMC Ophthalmol 3: 3 PubMed GONUTS page
- ↑ Xi JH et al. (2008) Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death. J Biol Chem 283: 5801-14 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Koh TJ & Escobedo J (2004) Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions. Am J Physiol Cell Physiol 286: C713-22 PubMed GONUTS page
- ↑ Xi JH et al. (2006) Alpha-crystallin expression affects microtubule assembly and prevents their aggregation. FASEB J 20: 846-57 PubMed GONUTS page
- ↑ Brady JP et al. (2001) AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach. Invest Ophthalmol Vis Sci 42: 2924-34 PubMed GONUTS page
- ↑ Bai F et al. (2007) Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Mol Vis 13: 1589-600 PubMed GONUTS page
- ↑ Yaung J et al. (2007) alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol Vis 13: 566-77 PubMed GONUTS page
