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MGI:Comt
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Comt ( synonyms: Comt1, D16Wsu103e ) | |
| Protein Name(s) | catechol-O-methyltransferase, | |
| External Links | ||
| MGI | MGI:88470 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3852644 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007565 |
female pregnancy |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007612 |
learning |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008168 |
methyltransferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0489 |
F |
From MGI |
||
| GO:0008210 |
estrogen metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009712 |
catechol-containing compound metabolic process |
MGI:MGI:4830461 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4830700 |
P |
From MGI |
||
| GO:0016206 |
catechol O-methyltransferase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016206 |
catechol O-methyltransferase activity |
MGI:MGI:4822307 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0016206 |
catechol O-methyltransferase activity |
MGI:MGI:4830461 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4830700 |
F |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0032259 |
methylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0489 |
P |
From MGI |
||
| GO:0032259 |
methylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032259 |
methylation |
MGI:MGI:4822307 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032259 |
methylation |
MGI:MGI:4830461 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4830700 |
P |
From MGI |
||
| GO:0042417 |
dopamine metabolic process |
MGI:MGI:4830461 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178542 |
P |
From MGI |
||
| GO:0042417 |
dopamine metabolic process |
MGI:MGI:4830461 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178542 |
P |
From MGI |
||
| GO:0042420 |
dopamine catabolic process |
MGI:MGI:2386819 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043231 |
intracellular membrane-bounded organelle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045963 |
negative regulation of dopamine metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048265 |
response to pain |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048609 |
multicellular organismal reproductive process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048662 |
negative regulation of smooth muscle cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050668 |
positive regulation of homocysteine metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
NOT |
GO:0005886 |
plasma membrane |
MGI:MGI:4822307 |
IDA: Inferred from Direct Assay |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Käenmäki M et al. (2009) Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice. Br J Pharmacol 158: 1884-94 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Myöhänen TT et al. (2010) Distribution of catechol-O-methyltransferase (COMT) proteins and enzymatic activities in wild-type and soluble COMT deficient mice. J Neurochem 113: 1632-43 PubMed GONUTS page
- ↑ Jones SR et al. (1998) Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A 95: 4029-34 PubMed GONUTS page
