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MGI:Col4a3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Col4a3 ( synonyms: alpha3(IV), tumstatin ) | |
| Protein Name(s) | collagen, type IV, alpha 3, | |
| External Links | ||
| MGI | MGI:104688 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005178 |
integrin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005201 |
extracellular matrix structural constituent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0272 |
C |
From MGI |
||
| GO:0005581 |
collagen |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0176 |
C |
From MGI |
||
| GO:0005581 |
collagen |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005587 |
collagen type IV |
MGI:MGI:2183884 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005587 |
collagen type IV |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005604 |
basement membrane |
MGI:MGI:2157737 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005604 |
basement membrane |
MGI:MGI:3776221 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005604 |
basement membrane |
MGI:MGI:3807344 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005604 |
basement membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0130 |
P |
From MGI |
||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:3706464 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008283 |
cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016525 |
negative regulation of angiogenesis |
MGI:MGI:3706481 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016525 |
negative regulation of angiogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032836 |
glomerular basement membrane development |
MGI:MGI:3610934 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Shindo T et al. (2002) Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med 8: 856-63 PubMed GONUTS page
- ↑ Nagai N et al. (2001) Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development. Int J Dev Biol 45: 827-31 PubMed GONUTS page
- ↑ Meyer zum Gottesberge AM & Felix H (2005) Abnormal basement membrane in the inner ear and the kidney of the Mpv17-/- mouse strain: ultrastructural and immunohistochemical investigations. Histochem Cell Biol 124: 507-16 PubMed GONUTS page
- ↑ Manabe R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A 105: 12849-54 PubMed GONUTS page
- ↑ Hamano Y et al. (2003) Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell 3: 589-601 PubMed GONUTS page
- ↑ Miyoshi T et al. (2006) Tumor-specific expression of the RGD-alpha3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice. FASEB J 20: 1904-6 PubMed GONUTS page
- ↑ Abrahamson DR et al. (2003) Laminin-1 reexpression in Alport mouse glomerular basement membranes. Kidney Int 63: 826-34 PubMed GONUTS page
