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MGI:Clock
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Clock ( synonyms: bHLHe8, KAT13D ) | |
| Protein Name(s) | circadian locomotor output cycles kaput, | |
| External Links | ||
| MGI | MGI:99698 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000077 |
DNA damage checkpoint |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000978 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0000982 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity |
MGI:MGI:5297789 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
MGI:MGI:2683983 |
IC: Inferred by Curator |
GO:0045944 |
F |
From MGI |
||
| GO:0001190 |
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription |
MGI:MGI:5306311 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2153999 |
ISA: Inferred from Sequence Alignment |
EMBL:AJ318057 |
F |
From MGI |
||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2179885 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004402 |
histone acetyltransferase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004871 |
signal transducer activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1276614 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3807720 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3807721 |
IPI: Inferred from Physical Interaction |
UniProtKB:O54943 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3829113 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4881368 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5294528 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2669067 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:3625767 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005694 |
chromosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2669067 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2179885 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From MGI |
||
| GO:0007165 |
signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007623 |
circadian rhythm |
MGI:MGI:2179885 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861634 |
P |
From MGI |
||
| GO:0007623 |
circadian rhythm |
MGI:MGI:2669067 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007623 |
circadian rhythm |
MGI:MGI:66027 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861634 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:2153999 |
ISA: Inferred from Sequence Alignment |
EMBL:AJ318057 |
F |
From MGI |
||
| GO:0016573 |
histone acetylation |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016746 |
transferase activity, transferring acyl groups |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0012 |
F |
From MGI |
||
| GO:0032922 |
circadian regulation of gene expression |
MGI:MGI:2683983 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032922 |
circadian regulation of gene expression |
MGI:MGI:5297789 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043231 |
intracellular membrane-bounded organelle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2683983 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3625767 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1096381 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3838062 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:5297789 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048511 |
rhythmic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0090 |
P |
From MGI |
||
| GO:0070888 |
E-box binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0071479 |
cellular response to ionizing radiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Hamaguchi H et al. (2004) Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem J 382: 43-50 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kawamoto T et al. (2004) A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun 313: 117-24 PubMed GONUTS page
- ↑ Sato F et al. (2004) Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur J Biochem 271: 4409-19 PubMed GONUTS page
- ↑ 4.0 4.1 Avivi A et al. (2001) Biological clock in total darkness: the Clock/MOP3 circadian system of the blind subterranean mole rat. Proc Natl Acad Sci U S A 98: 13751-6 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Cheng MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417: 405-10 PubMed GONUTS page
- ↑ Takahata S et al. (1998) Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock. Biochem Biophys Res Commun 248: 789-94 PubMed GONUTS page
- ↑ Nakahata Y et al. (2008) The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134: 329-40 PubMed GONUTS page
- ↑ Asher G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134: 317-28 PubMed GONUTS page
- ↑ Langmesser S et al. (2008) Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Mol Biol 9: 41 PubMed GONUTS page
- ↑ Asher G et al. (2010) Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142: 943-53 PubMed GONUTS page
- ↑ Ozber N et al. (2010) Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. BMC Mol Biol 11: 69 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Kondratov RV et al. (2003) BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev 17: 1921-32 PubMed GONUTS page
- ↑ 13.0 13.1 Yujnovsky I et al. (2006) Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci U S A 103: 6386-91 PubMed GONUTS page
- ↑ Vitaterna MH et al. (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264: 719-25 PubMed GONUTS page
- ↑ Duffield GE et al. (2009) A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr Biol 19: 297-304 PubMed GONUTS page
