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MGI:Cited2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cited2 ( synonyms: Mrg1, Msg2, p35srj ) | |
| Protein Name(s) | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, | |
| External Links | ||
| MGI | MGI:1306784 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001102 |
RNA polymerase II activating transcription factor binding |
MGI:MGI:2179743 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0001105 |
RNA polymerase II transcription coactivator activity |
MGI:MGI:2179743 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001105 |
RNA polymerase II transcription coactivator activity |
MGI:MGI:3690196 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001568 |
blood vessel development |
MGI:MGI:3606737 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0001570 |
vasculogenesis |
MGI:MGI:3628724 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
||
| GO:0001666 |
response to hypoxia |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3628724 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
||
| GO:0001829 |
trophectodermal cell differentiation |
MGI:MGI:3628724 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
||
| GO:0001841 |
neural tube formation |
MGI:MGI:2179743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0001843 |
neural tube closure |
MGI:MGI:2384266 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385355 |
P |
From MGI |
||
| GO:0001889 |
liver development |
MGI:MGI:3847632 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385355 |
P |
From MGI |
||
| GO:0001892 |
embryonic placenta development |
MGI:MGI:3628724 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
||
| GO:0001944 |
vasculature development |
MGI:MGI:3807101 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106918 |
P |
From MGI |
||
| GO:0001944 |
vasculature development |
MGI:MGI:3807101 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385355 |
P |
From MGI |
||
| GO:0001947 |
heart looping |
MGI:MGI:3574743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
||
| GO:0002089 |
lens morphogenesis in camera-type eye |
MGI:MGI:3807101 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3696062 |
P |
From MGI |
||
| GO:0002244 |
hemopoietic progenitor cell differentiation |
MGI:MGI:3847632 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385355 |
P |
From MGI |
||
| GO:0002521 |
leukocyte differentiation |
MGI:MGI:3847632 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385355 |
P |
From MGI |
||
| GO:0003151 |
outflow tract morphogenesis |
MGI:MGI:2179743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0003197 |
endocardial cushion development |
MGI:MGI:3574743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
||
| GO:0003281 |
ventricular septum development |
MGI:MGI:2384266 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385355 |
P |
From MGI |
||
| GO:0003281 |
ventricular septum development |
MGI:MGI:3574743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
||
| GO:0003682 |
chromatin binding |
MGI:MGI:3690196 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3807101 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003712 |
transcription cofactor activity |
MGI:MGI:2159043 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003714 |
transcription corepressor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3807101 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2159043 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3054669 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:3690196 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007417 |
central nervous system development |
MGI:MGI:2159043 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
||
| GO:0007422 |
peripheral nervous system development |
MGI:MGI:2179743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008283 |
cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008584 |
male gonad development |
MGI:MGI:3851651 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1346833 |
P |
From MGI |
||
| GO:0008584 |
male gonad development |
MGI:MGI:3851651 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98968 |
P |
From MGI |
||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0021602 |
cranial nerve morphogenesis |
MGI:MGI:2179743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0030325 |
adrenal gland development |
MGI:MGI:2179743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0030325 |
adrenal gland development |
MGI:MGI:3606737 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0030336 |
negative regulation of cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030851 |
granulocyte differentiation |
MGI:MGI:3847632 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385355 |
P |
From MGI |
||
| GO:0034405 |
response to fluid shear stress |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035360 |
positive regulation of peroxisome proliferator activated receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043627 |
response to estrogen stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046332 |
SMAD binding |
MGI:MGI:3690196 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0046697 |
decidualization |
MGI:MGI:3628724 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
||
| GO:0048538 |
thymus development |
MGI:MGI:4457799 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109360 |
P |
From MGI |
||
| GO:0048538 |
thymus development |
MGI:MGI:4457799 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0048596 |
embryonic camera-type eye morphogenesis |
MGI:MGI:3807101 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97490 |
P |
From MGI |
||
| GO:0048821 |
erythrocyte development |
MGI:MGI:3847632 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385355 |
P |
From MGI |
||
| GO:0050693 |
LBD domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0060136 |
embryonic process involved in female pregnancy |
MGI:MGI:3628724 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
||
| GO:0060349 |
bone morphogenesis |
MGI:MGI:4457799 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0060411 |
cardiac septum morphogenesis |
MGI:MGI:2179743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0061156 |
pulmonary artery morphogenesis |
MGI:MGI:2384266 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385355 |
P |
From MGI |
||
| GO:0061308 |
cardiac neural crest cell development involved in heart development |
MGI:MGI:2179743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179740 |
P |
From MGI |
||
| GO:0061371 |
determination of heart left/right asymmetry |
MGI:MGI:3574743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176158 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Bamforth SD et al. (2001) Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet 29: 469-74 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Chou YT et al. (2006) Cited2 modulates TGF-beta-mediated upregulation of MMP9. Oncogene 25: 5547-60 PubMed GONUTS page
- ↑ 3.0 3.1 Schneider JE et al. (2004) Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol 4: 16 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Withington SL et al. (2006) Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta. Dev Biol 294: 67-82 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Yin Z et al. (2002) The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A 99: 10488-93 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Chen Y et al. (2007) Cited2 is required for normal hematopoiesis in the murine fetal liver. Blood 110: 2889-98 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Chen Y et al. (2008) Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development 135: 2939-48 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Weninger WJ et al. (2005) Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development 132: 1337-48 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Barbera JP et al. (2002) Folic acid prevents exencephaly in Cited2 deficient mice. Hum Mol Genet 11: 283-93 PubMed GONUTS page
- ↑ Bamforth SD et al. (2004) Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet 36: 1189-96 PubMed GONUTS page
- ↑ 11.0 11.1 Buaas FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet 18: 2989-3001 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Michell AC et al. (2010) A novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2. Dev Dyn 239: 1988-94 PubMed GONUTS page
