MGI:Chuk

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0002011	morphogenesis of an epithelial sheet	MGI:MGI:3042351 PMID:14960276^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3045616	P	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:3578695 PMID:15684432^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O15111	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0723	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F	From MGI
	GO:0004702	receptor signaling protein serine/threonine kinase activity	MGI:MGI:1330055 PMID:9597130^[3]	TAS: Traceable Author Statement		F	From MGI
	GO:0005515	protein binding	MGI:MGI:3621577 PMID:16612387^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P70434	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3688344 PMID:15102471^[5]	IPI: Inferred from Physical Interaction	UniProtKB:B7ZNY0 UniProtKB:P02535 UniProtKB:Q8BP22	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3773773 PMID:10733566^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P25963 UniProtKB:Q99558	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4454346 PMID:20434986^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O88522	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4821187 PMID:20622870^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q91VL8	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5009780 PMID:20818435^[9]	IPI: Inferred from Physical Interaction	UniProtKB:O88522	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5315695 PMID:18266467^[10]	IPI: Inferred from Physical Interaction	UniProtKB:O88522	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441	F	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O15111	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:1330055 PMID:9597130^[3]	TAS: Traceable Author Statement		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O15111	C	From MGI
	GO:0005792	microsome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101058	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101058	C	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0723	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O15111	P	From MGI
	GO:0007252	I-kappaB phosphorylation	MGI:MGI:1330055 PMID:9597130^[3]	TAS: Traceable Author Statement		P	From MGI
	GO:0007252	I-kappaB phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101058	P	From MGI
	GO:0007266	Rho protein signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101058	P	From MGI
	GO:0007595	lactation	MGI:MGI:3045614 PMID:11747812^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:88313	P	From MGI
	GO:0007595	lactation	MGI:MGI:3045614 PMID:11747812^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3045616	P	From MGI
	GO:0008385	IkappaB kinase complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101058	C	From MGI
	GO:0009898	internal side of plasma membrane	MGI:MGI:4462284 PMID:20614026^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0010033	response to organic substance	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101058	P	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0030316	osteoclast differentiation	MGI:MGI:3525391 PMID:15485831^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:1100089 MGI:MGI:104798	P	From MGI
	GO:0030316	osteoclast differentiation	MGI:MGI:3525391 PMID:15485831^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857735	P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101058	P	From MGI
	GO:0033598	mammary gland epithelial cell proliferation	MGI:MGI:3045614 PMID:11747812^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:88313	P	From MGI
	GO:0033598	mammary gland epithelial cell proliferation	MGI:MGI:3045614 PMID:11747812^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3045616	P	From MGI
	GO:0035631	CD40 receptor complex	MGI:MGI:4462284 PMID:20614026^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0042475	odontogenesis of dentin-containing tooth	MGI:MGI:3042351 PMID:14960276^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3039784	P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:3045614 PMID:11747812^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:1100089	P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:3045614 PMID:11747812^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3045616	P	From MGI
	GO:0043231	intracellular membrane-bounded organelle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O15111	C	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101058	F	From MGI
	GO:0051146	striated muscle cell differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101058	P	From MGI
	GO:0060749	mammary gland alveolus development	MGI:MGI:3045614 PMID:11747812^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:88313	P	From MGI
	GO:0060749	mammary gland alveolus development	MGI:MGI:3045614 PMID:11747812^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3045616	P	From MGI
contributes_to	GO:0008384	IkappaB kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101058	F	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ohazama A et al. (2004) A dual role for Ikk alpha in tooth development. Dev Cell 6: 219-27 PubMed GONUTS page
↑ Makowski L et al. (2005) The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem 280: 12888-95 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Ghosh S et al. (1998) NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-60 PubMed GONUTS page
↑ Hoshino K et al. (2006) IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 440: 949-53 PubMed GONUTS page
↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
↑ McKenzie FR et al. (2000) Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements. Mol Cell Biol 20: 2635-49 PubMed GONUTS page
↑ Cui J et al. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 141: 483-96 PubMed GONUTS page
↑ Teo H et al. (2010) Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol 12: 758-67 PubMed GONUTS page
↑ Neely RJ et al. (2011) The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK. Oncogene 30: 87-96 PubMed GONUTS page
↑ Chen RA et al. (2008) Inhibition of IkappaB kinase by vaccinia virus virulence factor B14. PLoS Pathog 4: e22 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Cao Y et al. (2001) IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107: 763-75 PubMed GONUTS page
↑ ^12.0 ^12.1 Hostager BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One 5: e11380 PubMed GONUTS page
↑ ^13.0 ^13.1 Chaisson ML et al. (2004) Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha. J Biol Chem 279: 54841-8 PubMed GONUTS page

[PMID:14960276-0] 1.0 ^1.1 Ohazama A et al. (2004) A dual role for Ikk alpha in tooth development. Dev Cell 6: 219-27 PubMed GONUTS page

[PMID:15684432-1] Makowski L et al. (2005) The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem 280: 12888-95 PubMed GONUTS page

[PMID:9597130-2] 3.0 ^3.1 ^3.2 Ghosh S et al. (1998) NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-60 PubMed GONUTS page

[PMID:16612387-3] Hoshino K et al. (2006) IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 440: 949-53 PubMed GONUTS page

[PMID:15102471-4] Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page

[PMID:10733566-5] McKenzie FR et al. (2000) Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements. Mol Cell Biol 20: 2635-49 PubMed GONUTS page

[PMID:20434986-6] Cui J et al. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 141: 483-96 PubMed GONUTS page

[PMID:20622870-7] Teo H et al. (2010) Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol 12: 758-67 PubMed GONUTS page

[PMID:20818435-8] Neely RJ et al. (2011) The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK. Oncogene 30: 87-96 PubMed GONUTS page

[PMID:18266467-9] Chen RA et al. (2008) Inhibition of IkappaB kinase by vaccinia virus virulence factor B14. PLoS Pathog 4: e22 PubMed GONUTS page

[PMID:11747812-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Cao Y et al. (2001) IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107: 763-75 PubMed GONUTS page

[PMID:20614026-11] 12.0 ^12.1 Hostager BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One 5: e11380 PubMed GONUTS page

[PMID:15485831-12] 13.0 ^13.1 Chaisson ML et al. (2004) Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha. J Biol Chem 279: 54841-8 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Chuk ( synonyms: Chuk1, IkappaB kinase alpha, IKK 1, IKK alpha, IKK-1, IKK-alpha, IKK(a), IKK1, IKKalpha )
Protein Name(s)	conserved helix-loop-helix ubiquitous kinase,
External Links
MGI	MGI:99484

MGI:Chuk

Contents

Annotations

Notes

References

a

c

i

k

l

m

n

o

p

p cont.

r

s

t

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox