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MGI:Chrnb4

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Chrnb4 ( synonyms: Acrb-4, Acrb4 )
Protein Name(s) cholinergic receptor, nicotinic, beta polypeptide 4,
External Links
MGI MGI:87892

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001508

regulation of action potential

MGI:MGI:2156010
PMID:10531434[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:87891

P

From MGI

GO:0004872

receptor activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0675

F

From MGI

GO:0004889

acetylcholine-activated cation-selective channel activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR002394

F

From MGI

GO:0005216

ion channel activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0407

F

From MGI

GO:0005216

ion channel activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR002394

F

From MGI

GO:0005230

extracellular ligand-gated ion channel activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006202
InterPro:IPR018000

F

From MGI

GO:0005886

plasma membrane

MGI:MGI:3848633
PMID:19474315[2]

ISO: Inferred from Sequence Orthology

UniProtKB:P12392

C

From MGI

GO:0005892

acetylcholine-gated channel complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P12392

C

From MGI

GO:0005892

acetylcholine-gated channel complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P30926

C

From MGI

GO:0006810

transport

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From MGI

GO:0006810

transport

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006202

P

From MGI

GO:0006811

ion transport

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0406

P

From MGI

GO:0006811

ion transport

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006201
InterPro:IPR006029
InterPro:IPR018000
InterPro:IPR002394

P

From MGI

GO:0006812

cation transport

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR002394

P

From MGI

GO:0006939

smooth muscle contraction

MGI:MGI:2156010
PMID:10531434[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:87891

P

From MGI

GO:0006940

regulation of smooth muscle contraction

MGI:MGI:3607823
PMID:10771006[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158716

P

From MGI

GO:0007165

signal transduction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P30926

P

From MGI

GO:0007626

locomotory behavior

MGI:MGI:3574721
PMID:15275829[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158716

P

From MGI

GO:0015464

acetylcholine receptor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P30926

F

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016020

membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006202
InterPro:IPR006029

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR006201
InterPro:IPR018000
InterPro:IPR002394

C

From MGI

GO:0019717

synaptosome

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P12392

C

From MGI

GO:0030054

cell junction

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0965

C

From MGI

GO:0034220

ion transmembrane transport

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0407

P

From MGI

GO:0034220

ion transmembrane transport

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR002394

P

From MGI

GO:0035094

response to nicotine

MGI:MGI:2156010
PMID:10531434[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:87891

P

From MGI

GO:0035095

behavioral response to nicotine

MGI:MGI:3530984
PMID:15537871[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158716

P

From MGI

GO:0035095

behavioral response to nicotine

MGI:MGI:3574721
PMID:15275829[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158716

P

From MGI

GO:0042166

acetylcholine binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P12392

F

From MGI

GO:0042391

regulation of membrane potential

MGI:MGI:2156010
PMID:10531434[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:87891

P

From MGI

GO:0045202

synapse

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0770

C

From MGI

GO:0045211

postsynaptic membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0628

C

From MGI

GO:0045211

postsynaptic membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR018000
InterPro:IPR002394

C

From MGI

GO:0060084

synaptic transmission involved in micturition

MGI:MGI:2156010
PMID:10531434[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:87891

P

From MGI

GO:0060084

synaptic transmission involved in micturition

MGI:MGI:3607823
PMID:10771006[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2158716

P

From MGI

GO:0060084

synaptic transmission involved in micturition

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P30926

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 Xu W et al. (1999) Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors. J Neurosci 19: 9298-305 PubMed GONUTS page
  2. Rezvani K et al. (2009) UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. J Neurosci 29: 6883-96 PubMed GONUTS page
  3. 3.0 3.1 De Biasi M et al. (2000) Nicotinic acetylcholine receptors in the autonomic control of bladder function. Eur J Pharmacol 393: 137-40 PubMed GONUTS page
  4. 4.0 4.1 Salas R et al. (2004) The alpha3 and beta4 nicotinic acetylcholine receptor subunits are necessary for nicotine-induced seizures and hypolocomotion in mice. Neuropharmacology 47: 401-7 PubMed GONUTS page
  5. Salas R et al. (2004) Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit. J Neurosci 24: 10035-9 PubMed GONUTS page
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