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MGI:Chrd
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Chrd ( synonyms: Chd ) | |
| Protein Name(s) | chordin, | |
| External Links | ||
| MGI | MGI:1313268 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001501 |
skeletal system development |
MGI:MGI:2156257 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157350 |
P |
From MGI |
||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3525426 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001702 |
gastrulation with mouth forming second |
MGI:MGI:2662951 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157350 |
P |
From MGI |
||
| GO:0001707 |
mesoderm formation |
MGI:MGI:2662951 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157350 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3525426 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:3577114 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007389 |
pattern specification process |
MGI:MGI:2389288 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157350 |
P |
From MGI |
||
| GO:0007417 |
central nervous system development |
MGI:MGI:1353146 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157350 |
P |
From MGI |
||
| GO:0008201 |
heparin binding |
MGI:MGI:3525426 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:2662951 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157350 |
P |
From MGI |
||
| GO:0021919 |
BMP signaling pathway involved in spinal cord dorsal/ventral patterning |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030336 |
negative regulation of cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030514 |
negative regulation of BMP signaling pathway |
MGI:MGI:3577114 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030514 |
negative regulation of BMP signaling pathway |
MGI:MGI:4429763 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030514 |
negative regulation of BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030900 |
forebrain development |
MGI:MGI:2389288 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157350 |
P |
From MGI |
||
| GO:0045545 |
syndecan binding |
MGI:MGI:3525426 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045668 |
negative regulation of osteoblast differentiation |
MGI:MGI:3577114 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045785 |
positive regulation of cell adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Stottmann RW et al. (2001) The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth. Dev Biol 240: 457-73 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Jasuja R et al. (2004) Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. J Biol Chem 279: 51289-97 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Bachiller D et al. (2003) The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. Development 130: 3567-78 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Petryk A et al. (2005) Twisted gastrulation and chordin inhibit differentiation and mineralization in MC3T3-E1 osteoblast-like cells. Bone 36: 617-26 PubMed GONUTS page
- ↑ 5.0 5.1 Anderson RM et al. (2002) Chordin and noggin promote organizing centers of forebrain development in the mouse. Development 129: 4975-87 PubMed GONUTS page
- ↑ Bachiller D et al. (2000) The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature 403: 658-61 PubMed GONUTS page
- ↑ Misra K & Matise MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev Biol 337: 74-83 PubMed GONUTS page
