Have any questions? Please email us at ecoliwiki@gmail.com

MGI:Chek2

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Chek2 ( synonyms: CHK2, Rad53 )
Protein Name(s) checkpoint kinase 2,
External Links
MGI MGI:1355321

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000077

DNA damage checkpoint

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_446129

P

From MGI

GO:0000086

G2/M transition of mitotic cell cycle

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0000166

nucleotide binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From MGI

GO:0004672

protein kinase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_446129

F

From MGI

GO:0004674

protein serine/threonine kinase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_446129

F

From MGI

GO:0004674

protein serine/threonine kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

F

From MGI

GO:0005524

ATP binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From MGI

GO:0005524

ATP binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290

F

From MGI

GO:0005634

nucleus

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From MGI

GO:0006281

DNA repair

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0234

P

From MGI

GO:0006302

double-strand break repair

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_446129

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:3805397
PMID:18614044[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2386905

P

From MGI

GO:0006974

response to DNA damage stimulus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0006975

DNA damage induced protein phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0007049

cell cycle

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

From MGI

GO:0007067

mitosis

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

From MGI

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage response

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0010332

response to gamma radiation

MGI:MGI:3032464
PMID:14744935[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016301

kinase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_446129

F

From MGI

GO:0016310

phosphorylation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

From MGI

GO:0016605

PML body

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

C

From MGI

GO:0016740

transferase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

From MGI

GO:0016772

transferase activity, transferring phosphorus-containing groups

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

F

From MGI

GO:0031625

ubiquitin protein ligase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

F

From MGI

GO:0042176

regulation of protein catabolic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0042770

signal transduction in response to DNA damage

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0042770

signal transduction in response to DNA damage

MGI:MGI:3032464
PMID:14744935[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

F

From MGI

GO:0044257

cellular protein catabolic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0046777

protein autophosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0046872

metal ion binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From MGI

GO:0051301

cell division

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

From MGI

GO:0072428

signal transduction involved in intra-S DNA damage checkpoint

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI

GO:0090307

spindle assembly involved in mitosis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O96017

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Stracker, TH et al. (2008) Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol. Cell 31 21-32 PubMed GONUTS page
  2. 2.0 2.1 Qu, L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev. 18 261-77 PubMed GONUTS page
<protect>