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MGI:Cdkn2a

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Cdkn2a ( synonyms: Arf, ARF-INK4a, INK4a-ARF, Ink4a/Arf, MTS1, p16, p16INK4a, p19, p19ARF, Pctr1 )
Protein Name(s) cyclin-dependent kinase inhibitor 2A,
External Links
MGI MGI:104738

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000075

cell cycle checkpoint

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0000079

regulation of cyclin-dependent protein kinase activity

MGI:MGI:75940
PMID:7651726[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000082

G1/S transition of mitotic cell cycle

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0000209

protein polyubiquitination

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0001652

granular component

MGI:MGI:2387903
PMID:12154087[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0001953

negative regulation of cell-matrix adhesion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0002039

p53 binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

F

From MGI

GO:0003677

DNA binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:2387903
PMID:12154087[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004861

cyclin-dependent protein kinase inhibitor activity

MGI:MGI:2183076
PMID:12130539[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004861

cyclin-dependent protein kinase inhibitor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

F

From MGI

GO:0004861

cyclin-dependent protein kinase inhibitor activity

MGI:MGI:75940
PMID:7651726[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005515

protein binding

MGI:MGI:3828414
PMID:11259404[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q8VCI5

F

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_113738

C

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

C

From MGI

GO:0005654

nucleoplasm

MGI:MGI:2387903
PMID:12154087[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005654

nucleoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

C

From MGI

GO:0005730

nucleolus

MGI:MGI:2153973
PMID:11718560[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005730

nucleolus

MGI:MGI:2387903
PMID:12154087[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005730

nucleolus

MGI:MGI:3511401
PMID:15567177[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005730

nucleolus

MGI:MGI:3511413
PMID:15485902[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005730

nucleolus

MGI:MGI:3583493
PMID:15989966[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005730

nucleolus

MGI:MGI:3603875
PMID:16199867[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005730

nucleolus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2387903
PMID:12154087[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

C

From MGI

GO:0006309

DNA fragmentation involved in apoptotic nuclear change

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2387903
PMID:12154087[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006364

rRNA processing

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0698

P

From MGI

GO:0006469

negative regulation of protein kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0053

P

From MGI

GO:0006917

induction of apoptosis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0007049

cell cycle

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

From MGI

GO:0007050

cell cycle arrest

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0007050

cell cycle arrest

MGI:MGI:75940
PMID:7651726[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007568

aging

MGI:MGI:2153591
PMID:11551927[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857942

P

From MGI

GO:0007569

cell aging

MGI:MGI:2159048
PMID:11748239[11]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008134

transcription factor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

F

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0008544

epidermis development

MGI:MGI:2153591
PMID:11551927[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857942

P

From MGI

GO:0008637

apoptotic mitochondrial changes

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0009303

rRNA transcription

MGI:MGI:3822232
PMID:18809582[12]

IGI: Inferred from Genetic Interaction

MGI:MGI:98834

P

From MGI

GO:0010243

response to organic nitrogen

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_113738

P

From MGI

GO:0010389

regulation of G2/M transition of mitotic cell cycle

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0010468

regulation of gene expression

MGI:MGI:2137142
PMID:11438662[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1926877

P

From MGI

GO:0014070

response to organic cyclic compound

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_113738

P

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

F

From MGI

GO:0030308

negative regulation of cell growth

MGI:MGI:2387903
PMID:12154087[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0030308

negative regulation of cell growth

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0030889

negative regulation of B cell proliferation

MGI:MGI:3615850
PMID:15964995[14]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0031647

regulation of protein stability

MGI:MGI:2387903
PMID:12154087[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0031648

protein destabilization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0032088

negative regulation of NF-kappaB transcription factor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0033088

negative regulation of immature T cell proliferation in thymus

MGI:MGI:3615850
PMID:15964995[14]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0033235

positive regulation of protein sumoylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0033600

negative regulation of mammary gland epithelial cell proliferation

MGI:MGI:3047035
PMID:15105443[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1926877

P

From MGI

GO:0034393

positive regulation of smooth muscle cell apoptotic process

MGI:MGI:4943829
PMID:20381282[16]

IGI: Inferred from Genetic Interaction

UniProtKB:P08226

P

From MGI

GO:0035019

somatic stem cell maintenance

MGI:MGI:3829847
PMID:18957199[17]

IGI: Inferred from Genetic Interaction

MGI:MGI:101761

P

From MGI

GO:0035985

senescence-associated heterochromatin focus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

C

From MGI

GO:0035986

senescence-associated heterochromatin focus assembly

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0042326

negative regulation of phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0042493

response to drug

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_113738

P

From MGI

GO:0043234

protein complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

C

From MGI

GO:0043517

positive regulation of DNA damage response, signal transduction by p53 class mediator

MGI:MGI:1327100
PMID:9878046[18]

IC: Inferred by Curator

GO:0051444

P

From MGI

GO:0043517

positive regulation of DNA damage response, signal transduction by p53 class mediator

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0045736

negative regulation of cyclin-dependent protein kinase activity

MGI:MGI:2183076
PMID:12130539[3]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045736

negative regulation of cyclin-dependent protein kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0045786

negative regulation of cell cycle

MGI:MGI:3511413
PMID:15485902[7]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3830454
PMID:19057511[19]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0046822

regulation of nucleocytoplasmic transport

MGI:MGI:3511413
PMID:15485902[7]

IGI: Inferred from Genetic Interaction

MGI:MGI:106184

P

From MGI

GO:0046825

regulation of protein export from nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0048103

somatic stem cell division

MGI:MGI:3615850
PMID:15964995[14]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0050821

protein stabilization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0051059

NF-kappaB binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

F

From MGI

GO:0051091

positive regulation of sequence-specific DNA binding transcription factor activity

MGI:MGI:3830454
PMID:19057511[19]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0051444

negative regulation of ubiquitin-protein ligase activity

MGI:MGI:1327100
PMID:9878046[18]

IDA: Inferred from Direct Assay

P

From MGI

GO:0055105

ubiquitin-protein ligase inhibitor activity

MGI:MGI:1327100
PMID:9878046[18]

IDA: Inferred from Direct Assay

F

From MGI

GO:0060058

positive regulation of apoptotic process involved in mammary gland involution

MGI:MGI:3047035
PMID:15105443[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1926877

P

From MGI

GO:0070215

MDM2 binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

F

From MGI

GO:0070534

protein K63-linked ubiquitination

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0071158

positive regulation of cell cycle arrest

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0090398

cellular senescence

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8N726

P

From MGI

GO:0090399

replicative senescence

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI

GO:2000111

positive regulation of macrophage apoptotic process

MGI:MGI:4943829
PMID:20381282[16]

IGI: Inferred from Genetic Interaction

UniProtKB:P08226

P

From MGI

GO:2000774

positive regulation of cellular senescence

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P42771

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Quelle DE et al. (1995) Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene 11: 635-45 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Hasan MK et al. (2002) CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem 277: 37765-70 PubMed GONUTS page
  3. 3.0 3.1 Lazaro JB et al. (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev 16: 1792-805 PubMed GONUTS page
  4. Sugihara T et al. (2001) Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway. J Biol Chem 276: 18649-52 PubMed GONUTS page
  5. Bothner B et al. (2001) Defining the molecular basis of Arf and Hdm2 interactions. J Mol Biol 314: 263-77 PubMed GONUTS page
  6. Suzuki H et al. (2005) The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. Biochem Biophys Res Commun 326: 242-8 PubMed GONUTS page
  7. 7.0 7.1 7.2 Brady SN et al. (2004) ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol Cell Biol 24: 9327-38 PubMed GONUTS page
  8. Yuan X et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell 19: 77-87 PubMed GONUTS page
  9. Colombo E et al. (2005) Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol 25: 8874-86 PubMed GONUTS page
  10. 10.0 10.1 Paramio JM et al. (2001) The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis. J Biol Chem 276: 44203-11 PubMed GONUTS page
  11. Brummelkamp TR et al. (2002) TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J Biol Chem 277: 6567-72 PubMed GONUTS page
  12. Maggi LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol 28: 7050-65 PubMed GONUTS page
  13. Eischen CM et al. (2001) Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Mol Cell Biol 21: 5063-70 PubMed GONUTS page
  14. 14.0 14.1 14.2 Bruggeman SW et al. (2005) Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev 19: 1438-43 PubMed GONUTS page
  15. 15.0 15.1 Yi Y et al. (2004) p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development. Mol Biol Cell 15: 2302-11 PubMed GONUTS page
  16. 16.0 16.1 González-Navarro H et al. (2010) p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis. J Am Coll Cardiol 55: 2258-68 PubMed GONUTS page
  17. Nishino J et al. (2008) Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell 135: 227-39 PubMed GONUTS page
  18. 18.0 18.1 18.2 Honda R & Yasuda H (1999) Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J 18: 22-7 PubMed GONUTS page
  19. 19.0 19.1 Yu J et al. (2009) PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J 28: 21-33 PubMed GONUTS page
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