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MGI:Cdkn2a
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cdkn2a ( synonyms: Arf, ARF-INK4a, INK4a-ARF, Ink4a/Arf, MTS1, p16, p16INK4a, p19, p19ARF, Pctr1 ) | |
| Protein Name(s) | cyclin-dependent kinase inhibitor 2A, | |
| External Links | ||
| MGI | MGI:104738 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000075 |
cell cycle checkpoint |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000079 |
regulation of cyclin-dependent protein kinase activity |
MGI:MGI:75940 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000082 |
G1/S transition of mitotic cell cycle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000209 |
protein polyubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001652 |
granular component |
MGI:MGI:2387903 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001953 |
negative regulation of cell-matrix adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002039 |
p53 binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2387903 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004861 |
cyclin-dependent protein kinase inhibitor activity |
MGI:MGI:2183076 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004861 |
cyclin-dependent protein kinase inhibitor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004861 |
cyclin-dependent protein kinase inhibitor activity |
MGI:MGI:75940 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3828414 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_113738 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005654 |
nucleoplasm |
MGI:MGI:2387903 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005654 |
nucleoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:2153973 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:2387903 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:3511401 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:3511413 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:3583493 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:3603875 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2387903 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2387903 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006364 |
rRNA processing |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0698 |
P |
From MGI |
||
| GO:0006469 |
negative regulation of protein kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007049 |
cell cycle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From MGI |
||
| GO:0007050 |
cell cycle arrest |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007050 |
cell cycle arrest |
MGI:MGI:75940 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007568 |
aging |
MGI:MGI:2153591 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857942 |
P |
From MGI |
||
| GO:0007569 |
cell aging |
MGI:MGI:2159048 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008544 |
epidermis development |
MGI:MGI:2153591 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857942 |
P |
From MGI |
||
| GO:0008637 |
apoptotic mitochondrial changes |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009303 |
rRNA transcription |
MGI:MGI:3822232 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98834 |
P |
From MGI |
||
| GO:0010243 |
response to organic nitrogen |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_113738 |
P |
From MGI |
||
| GO:0010389 |
regulation of G2/M transition of mitotic cell cycle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:2137142 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926877 |
P |
From MGI |
||
| GO:0014070 |
response to organic cyclic compound |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_113738 |
P |
From MGI |
||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:2387903 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030889 |
negative regulation of B cell proliferation |
MGI:MGI:3615850 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0031647 |
regulation of protein stability |
MGI:MGI:2387903 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0031648 |
protein destabilization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033088 |
negative regulation of immature T cell proliferation in thymus |
MGI:MGI:3615850 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033235 |
positive regulation of protein sumoylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033600 |
negative regulation of mammary gland epithelial cell proliferation |
MGI:MGI:3047035 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926877 |
P |
From MGI |
||
| GO:0034393 |
positive regulation of smooth muscle cell apoptotic process |
MGI:MGI:4943829 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0035019 |
somatic stem cell maintenance |
MGI:MGI:3829847 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101761 |
P |
From MGI |
||
| GO:0035985 |
senescence-associated heterochromatin focus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035986 |
senescence-associated heterochromatin focus assembly |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042326 |
negative regulation of phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_113738 |
P |
From MGI |
||
| GO:0043234 |
protein complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043517 |
positive regulation of DNA damage response, signal transduction by p53 class mediator |
MGI:MGI:1327100 |
IC: Inferred by Curator |
GO:0051444 |
P |
From MGI |
||
| GO:0043517 |
positive regulation of DNA damage response, signal transduction by p53 class mediator |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045736 |
negative regulation of cyclin-dependent protein kinase activity |
MGI:MGI:2183076 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045736 |
negative regulation of cyclin-dependent protein kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045786 |
negative regulation of cell cycle |
MGI:MGI:3511413 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3830454 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046822 |
regulation of nucleocytoplasmic transport |
MGI:MGI:3511413 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106184 |
P |
From MGI |
||
| GO:0046825 |
regulation of protein export from nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048103 |
somatic stem cell division |
MGI:MGI:3615850 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050821 |
protein stabilization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051059 |
NF-kappaB binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:3830454 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051444 |
negative regulation of ubiquitin-protein ligase activity |
MGI:MGI:1327100 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0055105 |
ubiquitin-protein ligase inhibitor activity |
MGI:MGI:1327100 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0060058 |
positive regulation of apoptotic process involved in mammary gland involution |
MGI:MGI:3047035 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926877 |
P |
From MGI |
||
| GO:0070215 |
MDM2 binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0070534 |
protein K63-linked ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071158 |
positive regulation of cell cycle arrest |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090398 |
cellular senescence |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090399 |
replicative senescence |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000111 |
positive regulation of macrophage apoptotic process |
MGI:MGI:4943829 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:2000774 |
positive regulation of cellular senescence |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Quelle DE et al. (1995) Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene 11: 635-45 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Hasan MK et al. (2002) CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem 277: 37765-70 PubMed GONUTS page
- ↑ 3.0 3.1 Lazaro JB et al. (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev 16: 1792-805 PubMed GONUTS page
- ↑ Sugihara T et al. (2001) Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway. J Biol Chem 276: 18649-52 PubMed GONUTS page
- ↑ Bothner B et al. (2001) Defining the molecular basis of Arf and Hdm2 interactions. J Mol Biol 314: 263-77 PubMed GONUTS page
- ↑ Suzuki H et al. (2005) The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. Biochem Biophys Res Commun 326: 242-8 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Brady SN et al. (2004) ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol Cell Biol 24: 9327-38 PubMed GONUTS page
- ↑ Yuan X et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell 19: 77-87 PubMed GONUTS page
- ↑ Colombo E et al. (2005) Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol 25: 8874-86 PubMed GONUTS page
- ↑ 10.0 10.1 Paramio JM et al. (2001) The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis. J Biol Chem 276: 44203-11 PubMed GONUTS page
- ↑ Brummelkamp TR et al. (2002) TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J Biol Chem 277: 6567-72 PubMed GONUTS page
- ↑ Maggi LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol 28: 7050-65 PubMed GONUTS page
- ↑ Eischen CM et al. (2001) Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Mol Cell Biol 21: 5063-70 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Bruggeman SW et al. (2005) Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev 19: 1438-43 PubMed GONUTS page
- ↑ 15.0 15.1 Yi Y et al. (2004) p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development. Mol Biol Cell 15: 2302-11 PubMed GONUTS page
- ↑ 16.0 16.1 González-Navarro H et al. (2010) p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis. J Am Coll Cardiol 55: 2258-68 PubMed GONUTS page
- ↑ Nishino J et al. (2008) Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell 135: 227-39 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 Honda R & Yasuda H (1999) Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J 18: 22-7 PubMed GONUTS page
- ↑ 19.0 19.1 Yu J et al. (2009) PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J 28: 21-33 PubMed GONUTS page