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MGI:Cdk5
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cdk5 ( synonyms: Crk6 ) | |
| Protein Name(s) | cyclin-dependent kinase 5, | |
| External Links | ||
| MGI | MGI:101765 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001764 |
neuron migration |
MGI:MGI:1340775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0001764 |
neuron migration |
MGI:MGI:3040735 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3043819 |
P |
From MGI |
||
| GO:0001963 |
synaptic transmission, dopaminergic |
MGI:MGI:3033267 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002039 |
p53 binding |
MGI:MGI:3720993 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:1931637 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:1934092 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2149271 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2181933 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:3033267 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:3607648 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
F |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:3621856 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:3701155 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:3708210 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:3709145 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:4941854 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4941828 |
F |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:87730 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:893308 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:2673122 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:3525388 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4941854 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004693 |
cyclin-dependent protein kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005176 |
ErbB-2 class receptor binding |
MGI:MGI:3688080 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2446382 |
IPI: Inferred from Physical Interaction |
RefSeq:NP_034001 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3688080 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4941854 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:1889058 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:3040789 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3720993 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:82809 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:892714 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3040789 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:84679 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:892714 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:2446382 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:893308 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:2149271 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:3525388 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:3621856 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:3701155 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:3708210 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:3709145 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:3720993 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006886 |
intracellular protein transport |
MGI:MGI:1889058 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0006887 |
exocytosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006913 |
nucleocytoplasmic transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:87730 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007049 |
cell cycle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007160 |
cell-matrix adhesion |
MGI:MGI:2446382 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007399 |
nervous system development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0524 |
P |
From MGI |
||
| GO:0007409 |
axonogenesis |
MGI:MGI:1928548 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007416 |
synapse assembly |
MGI:MGI:4941854 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007519 |
skeletal muscle tissue development |
MGI:MGI:892714 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008045 |
motor axon guidance |
MGI:MGI:3607648 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008219 |
cell death |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0523 |
P |
From MGI |
||
| GO:0008306 |
associative learning |
MGI:MGI:2178910 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008542 |
visual learning |
MGI:MGI:3720432 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3720892 |
P |
From MGI |
||
| GO:0008633 |
activation of pro-apoptotic gene products |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009611 |
response to wounding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009790 |
embryo development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014044 |
Schwann cell development |
MGI:MGI:3607648 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0014069 |
postsynaptic density |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016310 |
phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016477 |
cell migration |
MGI:MGI:2446382 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016477 |
cell migration |
MGI:MGI:3763708 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0016477 |
cell migration |
MGI:MGI:3764566 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3043819 |
P |
From MGI |
||
| GO:0016533 |
cyclin-dependent protein kinase 5 holoenzyme complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:4941854 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:4941854 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4941828 |
P |
From MGI |
||
| GO:0018107 |
peptidyl-threonine phosphorylation |
MGI:MGI:4941854 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019233 |
sensory perception of pain |
MGI:MGI:3701155 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3043819 |
P |
From MGI |
||
| GO:0021537 |
telencephalon development |
MGI:MGI:3764566 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3043819 |
P |
From MGI |
||
| GO:0021549 |
cerebellum development |
MGI:MGI:1931637 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0021695 |
cerebellar cortex development |
MGI:MGI:1889058 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0021697 |
cerebellar cortex formation |
MGI:MGI:1340775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0021766 |
hippocampus development |
MGI:MGI:2149271 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0021819 |
layer formation in cerebral cortex |
MGI:MGI:2149271 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0021954 |
central nervous system neuron development |
MGI:MGI:1889058 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0021987 |
cerebral cortex development |
MGI:MGI:1277606 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0022038 |
corpus callosum development |
MGI:MGI:3764566 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3043819 |
P |
From MGI |
||
| GO:0030027 |
lamellipodium |
MGI:MGI:2446382 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030175 |
filopodium |
MGI:MGI:2446382 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030182 |
neuron differentiation |
MGI:MGI:3607011 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0030182 |
neuron differentiation |
MGI:MGI:3708210 |
ISA: Inferred from Sequence Alignment |
P |
From MGI |
|||
| GO:0030182 |
neuron differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030334 |
regulation of cell migration |
MGI:MGI:2673122 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0030424 |
axon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:84679 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030426 |
growth cone |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030549 |
acetylcholine receptor activator activity |
MGI:MGI:3688080 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0030866 |
cortical actin cytoskeleton organization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030900 |
forebrain development |
MGI:MGI:3763708 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0031175 |
neuron projection development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031397 |
negative regulation of protein ubiquitination |
MGI:MGI:3720993 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0031594 |
neuromuscular junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031914 |
negative regulation of synaptic plasticity |
MGI:MGI:3720432 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3720892 |
P |
From MGI |
||
| GO:0032092 |
positive regulation of protein binding |
MGI:MGI:4941854 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4941830 |
P |
From MGI |
||
| GO:0032801 |
receptor catabolic process |
MGI:MGI:3720432 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3720892 |
P |
From MGI |
||
| GO:0033136 |
serine phosphorylation of STAT3 protein |
MGI:MGI:3040789 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035249 |
synaptic transmission, glutamatergic |
MGI:MGI:3033267 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035418 |
protein localization to synapse |
MGI:MGI:4941854 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042220 |
response to cocaine |
MGI:MGI:3033267 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042995 |
cell projection |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0966 |
C |
From MGI |
||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043113 |
receptor clustering |
MGI:MGI:3607648 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0043125 |
ErbB-3 class receptor binding |
MGI:MGI:3688080 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043525 |
positive regulation of neuron apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044428 |
nuclear part |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045055 |
regulated secretory pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0770 |
C |
From MGI |
||
| GO:0045211 |
postsynaptic membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0628 |
C |
From MGI |
||
| GO:0045786 |
negative regulation of cell cycle |
MGI:MGI:3607011 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0045860 |
positive regulation of protein kinase activity |
MGI:MGI:3607648 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045956 |
positive regulation of calcium ion-dependent exocytosis |
MGI:MGI:3709145 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046826 |
negative regulation of protein export from nucleus |
MGI:MGI:3720993 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046875 |
ephrin receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048148 |
behavioral response to cocaine |
MGI:MGI:3764563 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3720892 |
P |
From MGI |
||
| GO:0048167 |
regulation of synaptic plasticity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048488 |
synaptic vesicle endocytosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048709 |
oligodendrocyte differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048812 |
neuron projection morphogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048813 |
dendrite morphogenesis |
MGI:MGI:3621856 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0048813 |
dendrite morphogenesis |
MGI:MGI:3696283 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050321 |
tau-protein kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051301 |
cell division |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0132 |
P |
From MGI |
||
| GO:0051402 |
neuron apoptotic process |
MGI:MGI:3720993 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051402 |
neuron apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060078 |
regulation of postsynaptic membrane potential |
MGI:MGI:3607648 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861809 |
P |
From MGI |
||
| GO:0060079 |
regulation of excitatory postsynaptic membrane potential |
MGI:MGI:3720432 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3720892 |
P |
From MGI |
||
| GO:0061001 |
regulation of dendritic spine morphogenesis |
MGI:MGI:3696283 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070509 |
calcium ion import |
MGI:MGI:4941854 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0090314 |
positive regulation of protein targeting to membrane |
MGI:MGI:4941854 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4941830 |
P |
From MGI |
||
|
NOT |
GO:0005730 |
nucleolus |
MGI:MGI:84679 |
IDA: Inferred from Direct Assay |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ohshima T et al. (1999) Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous. J Neurosci 19: 6017-26 PubMed GONUTS page
- ↑ Hirasawa M et al. (2004) Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc Natl Acad Sci U S A 101: 6249-54 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Chergui K et al. (2004) Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proc Natl Acad Sci U S A 101: 2191-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Lee JH et al. (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J Cell Sci 120: 2259-71 PubMed GONUTS page
- ↑ 5.0 5.1 Ohshima T et al. (2001) Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci U S A 98: 2764-9 PubMed GONUTS page
- ↑ Nguyen MD et al. (2001) Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30: 135-47 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Ko J et al. (2001) p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci 21: 6758-71 PubMed GONUTS page
- ↑ Keshvara L et al. (2002) Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling. J Neurosci 22: 4869-77 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Fu AK et al. (2005) Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc Natl Acad Sci U S A 102: 15224-9 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Sasaki Y et al. (2002) Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35: 907-20 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Pareek TK et al. (2007) Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A 104: 660-5 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Li T et al. (2007) Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J Biol Chem 282: 6619-28 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Lilja L et al. (2004) Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. J Biol Chem 279: 29534-41 PubMed GONUTS page
- ↑ 14.00 14.01 14.02 14.03 14.04 14.05 14.06 14.07 14.08 14.09 14.10 Samuels BA et al. (2007) Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 56: 823-37 PubMed GONUTS page
- ↑ 15.0 15.1 Zhang Q et al. (1997) Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling. Dev Biol 183: 222-33 PubMed GONUTS page
- ↑ 16.0 16.1 Lazzaro MA et al. (1997) A novel cdc2-related protein kinase expressed in the nervous system. J Neurochem 69: 348-64 PubMed GONUTS page
- ↑ 17.0 17.1 Xie Z et al. (2003) Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell 114: 469-82 PubMed GONUTS page
- ↑ 18.0 18.1 Li Z et al. (2004) Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. J Biol Chem 279: 54438-44 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 19.3 Fu AK et al. (2001) Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat Neurosci 4: 374-81 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 20.3 20.4 20.5 Gao C et al. (2002) CDK5 regulates cell adhesion and migration in corneal epithelial cells. Mol Cancer Res 1: 12-24 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 21.3 Ohshima T et al. (1996) Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci U S A 93: 11173-8 PubMed GONUTS page
- ↑ 22.0 22.1 22.2 Fu AK et al. (2004) Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc Natl Acad Sci U S A 101: 6728-33 PubMed GONUTS page
- ↑ Ino H & Chiba T (1996) Intracellular localization of cyclin-dependent kinase 5 (CDK5) in mouse neuron: CDK5 is located in both nucleus and cytoplasm. Brain Res 732: 179-85 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 Lazaro JB et al. (1997) Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells. J Cell Sci 110 ( Pt 10): 1251-60 PubMed GONUTS page
- ↑ 25.0 25.1 25.2 Eiden LE et al. (1987) A nomenclature proposal for the chromogranin/secretogranin proteins. Neuroscience 21: 1019-21 PubMed GONUTS page
- ↑ Niethammer M et al. (2000) NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron 28: 697-711 PubMed GONUTS page
- ↑ Fischer A et al. (2002) Cyclin-dependent kinase 5 is required for associative learning. J Neurosci 22: 3700-7 PubMed GONUTS page
- ↑ 28.0 28.1 28.2 28.3 Hawasli AH et al. (2007) Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat Neurosci 10: 880-6 PubMed GONUTS page
- ↑ 29.0 29.1 Remedios R et al. (2007) A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nat Neurosci 10: 1141-50 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 Hirota Y et al. (2007) Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. J Neurosci 27: 12829-38 PubMed GONUTS page
- ↑ Gilmore EC et al. (1998) Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex. J Neurosci 18: 6370-7 PubMed GONUTS page
- ↑ 32.0 32.1 Cicero S & Herrup K (2005) Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation. J Neurosci 25: 9658-68 PubMed GONUTS page
- ↑ Benavides DR et al. (2007) Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability. J Neurosci 27: 12967-76 PubMed GONUTS page
- ↑ 34.0 34.1 Fu WY et al. (2007) Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci 10: 67-76 PubMed GONUTS page
