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MGI:Cdk2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cdk2 | |
| Protein Name(s) | cyclin-dependent kinase 2, | |
| External Links | ||
| MGI | MGI:104772 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000307 |
cyclin-dependent protein kinase holoenzyme complex |
MGI:MGI:2677082 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0000307 |
cyclin-dependent protein kinase holoenzyme complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0000781 |
chromosome, telomeric region |
MGI:MGI:3757893 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:3757893 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000805 |
X chromosome |
MGI:MGI:3757893 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000806 |
Y chromosome |
MGI:MGI:3757893 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:5140640 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0723 |
F |
From MGI |
||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004693 |
cyclin-dependent protein kinase activity |
MGI:MGI:2675510 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004693 |
cyclin-dependent protein kinase activity |
MGI:MGI:2677082 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004693 |
cyclin-dependent protein kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004693 |
cyclin-dependent protein kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2677082 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4412428 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:67412 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4410401 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:1333653 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005768 |
endosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0006281 |
DNA repair |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0234 |
P |
From MGI |
||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:2384369 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006813 |
potassium ion transport |
MGI:MGI:3695173 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1929183 |
P |
From MGI |
||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From MGI |
||
| GO:0007049 |
cell cycle |
MGI:MGI:2675510 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007049 |
cell cycle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007049 |
cell cycle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007067 |
mitosis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0498 |
P |
From MGI |
||
| GO:0007126 |
meiosis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0469 |
P |
From MGI |
||
| GO:0015030 |
Cajal body |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:2384369 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016572 |
histone phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030332 |
cyclin binding |
MGI:MGI:3617096 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0030332 |
cyclin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032298 |
positive regulation of DNA-dependent DNA replication initiation |
MGI:MGI:4439421 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1920234 |
P |
From MGI |
||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032869 |
cellular response to insulin stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3609508 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108069 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0051301 |
cell division |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0132 |
P |
From MGI |
||
| GO:0051591 |
response to cAMP |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051602 |
response to electrical stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060968 |
regulation of gene silencing |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Woo M et al. (2003) Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat Immunol 4: 1016-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Ward JO et al. (2007) Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. PLoS Genet 3: e139 PubMed GONUTS page
- ↑ Hu MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood 117: 6120-31 PubMed GONUTS page
- ↑ 4.0 4.1 Hurlin PJ et al. (2003) Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J 22: 4584-96 PubMed GONUTS page
- ↑ Kalaszczynska I et al. (2009) Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 138: 352-65 PubMed GONUTS page
- ↑ Toyoshima H & Hunter T (1994) p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78: 67-74 PubMed GONUTS page
- ↑ Mateo F et al. (2009) The transcriptional co-activator PCAF regulates cdk2 activity. Nucleic Acids Res 37: 7072-84 PubMed GONUTS page
- ↑ Timchenko NA et al. (1999) C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol Cell Biol 19: 2936-45 PubMed GONUTS page
- ↑ 9.0 9.1 Vairapandi M et al. (2002) GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J Cell Physiol 192: 327-38 PubMed GONUTS page
- ↑ Jansen LA et al. (2005) Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes. Epilepsia 46: 1871-80 PubMed GONUTS page
- ↑ Jaime M et al. (2002) The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers. Hepatology 35: 1063-71 PubMed GONUTS page
- ↑ Copeland NA et al. (2010) Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro. J Cell Sci 123: 1108-15 PubMed GONUTS page
- ↑ Hara KT et al. (2005) Cyclin A2-CDK2 regulates embryonic gene activation in 1-cell mouse embryos. Dev Biol 286: 102-13 PubMed GONUTS page
