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MGI:Cdh2

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Cdh2 ( synonyms: N-cadherin, Ncad )
Protein Name(s) cadherin 2,
External Links
MGI MGI:88355

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005509

calcium ion binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR002126
InterPro:IPR015919
InterPro:IPR000233
InterPro:IPR009124

F

From MGI

GO:0005515

protein binding

MGI:MGI:3717517
PMID:11106648[1]

IPI: Inferred from Physical Interaction

UniProtKB:P18031

F

From MGI

GO:0005515

protein binding

MGI:MGI:3821807
PMID:18794329[2]

IPI: Inferred from Physical Interaction

UniProtKB:P30999

F

From MGI

GO:0005515

protein binding

MGI:MGI:3835914
PMID:19075000[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q91VN0
UniProtKB:O888572

F

From MGI

GO:0005515

protein binding

MGI:MGI:4439190
PMID:20160094[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q32MD9
UniProtKB:P47811

F

From MGI

GO:0005624

membrane fraction

MGI:MGI:4420359
PMID:19723622[5]

ISO: Inferred from Sequence Orthology

UniProtKB:Q9Z1Y3

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P19022

C

From MGI

GO:0005912

adherens junction

MGI:MGI:2386380
PMID:12203715[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005912

adherens junction

MGI:MGI:2656687
PMID:12695331[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005912

adherens junction

MGI:MGI:2661368
PMID:12052883[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005912

adherens junction

MGI:MGI:3664674
PMID:16892058[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005912

adherens junction

MGI:MGI:3790380
PMID:18239929[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P19022

C

From MGI

GO:0005916

fascia adherens

MGI:MGI:2154656
PMID:11732910[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005916

fascia adherens

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

C

From MGI

GO:0007155

cell adhesion

MGI:MGI:2665243
PMID:12738802[12]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007155

cell adhesion

MGI:MGI:3028451
PMID:14657280[13]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007156

homophilic cell adhesion

MGI:MGI:2683380
PMID:14561752[14]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007156

homophilic cell adhesion

MGI:MGI:62990
PMID:8270638[15]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007157

heterophilic cell-cell adhesion

MGI:MGI:62990
PMID:8270638[15]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007416

synapse assembly

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

P

From MGI

GO:0008013

beta-catenin binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

F

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016020

membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR002126
InterPro:IPR015919
InterPro:IPR000233
InterPro:IPR009124

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0016337

cell-cell adhesion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

P

From MGI

GO:0016339

calcium-dependent cell-cell adhesion

MGI:MGI:2683380
PMID:14561752[14]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016339

calcium-dependent cell-cell adhesion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

P

From MGI

GO:0016342

catenin complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P19022

C

From MGI

GO:0016477

cell migration

MGI:MGI:2683380
PMID:14561752[14]

IDA: Inferred from Direct Assay

P

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

F

From MGI

GO:0019903

protein phosphatase binding

MGI:MGI:3689290
PMID:16973135[16]

IPI: Inferred from Physical Interaction

UniProtKB:O14522

F

From MGI

GO:0030027

lamellipodium

MGI:MGI:3028451
PMID:14657280[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0031641

regulation of myelination

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

P

From MGI

GO:0032403

protein complex binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

F

From MGI

GO:0032880

regulation of protein localization

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

P

From MGI

GO:0035023

regulation of Rho protein signal transduction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

P

From MGI

GO:0042153

RPTP-like protein binding

MGI:MGI:3689290
PMID:16973135[16]

IPI: Inferred from Physical Interaction

UniProtKB:Q99M80

F

From MGI

GO:0043234

protein complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

C

From MGI

GO:0043410

positive regulation of MAPK cascade

MGI:MGI:4439190
PMID:20160094[4]

IGI: Inferred from Genetic Interaction

MGI:MGI:1926387
MGI:MGI:109327
MGI:MGI:1918084

P

From MGI

GO:0044456

synapse part

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

C

From MGI

GO:0045202

synapse

MGI:MGI:2680876
PMID:14622577[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0045202

synapse

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

C

From MGI

GO:0045294

alpha-catenin binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P19022

F

From MGI

GO:0045295

gamma-catenin binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P19022

F

From MGI

GO:0048514

blood vessel morphogenesis

MGI:MGI:3578460
PMID:15809310[18]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3522469

P

From MGI

GO:0050770

regulation of axonogenesis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

P

From MGI

GO:0051146

striated muscle cell differentiation

MGI:MGI:4439190
PMID:20160094[4]

IGI: Inferred from Genetic Interaction

MGI:MGI:1926387
MGI:MGI:109327
MGI:MGI:1918084
MGI:MGI:1346865

P

From MGI

GO:0051291

protein heterooligomerization

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112623

P

From MGI

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

MGI:MGI:3835914
PMID:19075000[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:98956
MGI:MGI:1278315

P

From MGI


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ Rhee J et al. (2001) Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin. J Biol Chem 276: 6640-4 PubMed GONUTS page
  2. ↑ Hirano M et al. (2008) EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol 182: 1217-30 PubMed GONUTS page
  3. ↑ 3.0 3.1 Haÿ E et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol Cell Biol 29: 953-64 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Lu M & Krauss RS (2010) N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts. Proc Natl Acad Sci U S A 107: 4212-7 PubMed GONUTS page
  5. ↑ Sato M et al. (2009) Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J Biol Chem 284: 31431-40 PubMed GONUTS page
  6. ↑ Sinn HW et al. (2002) Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Dev Dyn 225: 1-13 PubMed GONUTS page
  7. ↑ Lallemand D et al. (2003) NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev 17: 1090-100 PubMed GONUTS page
  8. ↑ Hollnagel A et al. (2002) The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. Mol Cell Biol 22: 4760-70 PubMed GONUTS page
  9. ↑ Cappello S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci 9: 1099-107 PubMed GONUTS page
  10. ↑ Manning JA et al. (2008) Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development. Histochem Cell Biol 129: 751-64 PubMed GONUTS page
  11. ↑ Zhang JQ et al. (2001) Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Biochemistry 40: 14898-906 PubMed GONUTS page
  12. ↑ Iijima Y et al. (2003) Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes. FASEB J 17: 1361-3 PubMed GONUTS page
  13. ↑ 13.0 13.1 Gavard J et al. (2004) Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J Cell Sci 117: 257-70 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 Guo HB et al. (2003) N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J Biol Chem 278: 52412-24 PubMed GONUTS page
  15. ↑ 15.0 15.1 Matsunami H et al. (1993) Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. J Cell Sci 106 ( Pt 1): 401-9 PubMed GONUTS page
  16. ↑ 16.0 16.1 Besco JA et al. (2006) Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT). Brain Res 1116: 50-7 PubMed GONUTS page
  17. ↑ Bamji SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40: 719-31 PubMed GONUTS page
  18. ↑ Luo Y & Radice GL (2005) N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. J Cell Biol 169: 29-34 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/MGI:Cdh2"
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