MGI:Cdc42

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000139	Golgi membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	C	From MGI
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0002040	sprouting angiogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0003161	cardiac conduction system development	MGI:MGI:5052204 PMID:21690310^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:97350	P	From MGI
	GO:0003334	keratinocyte development	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0003924	GTPase activity	MGI:MGI:1929482 PMID:10490598^[3]	TAS: Traceable Author Statement		F	From MGI
	GO:0003924	GTPase activity	MGI:MGI:2447568 PMID:10699171^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003924	GTPase activity	MGI:MGI:2662668 PMID:12637522^[5]	ISA: Inferred from Sequence Alignment	RefSeq:NP_001782	F	From MGI
	GO:0003924	GTPase activity	MGI:MGI:3050945 PMID:15249579^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005515	protein binding	MGI:MGI:1929482 PMID:10490598^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QZT9	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2663651 PMID:12773384^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q80YF9	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3529612 PMID:15710388^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q5KTP7 UniProtKB:Q8BIK4 UniProtKB:Q8BZN6	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3583726 PMID:15996550^[9]	IPI: Inferred from Physical Interaction	UniProtKB:O88643	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3590361 PMID:16052498^[10]	IPI: Inferred from Physical Interaction	UniProtKB:O54967	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3616720 PMID:16510873^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q02956	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3687818 PMID:10954424^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q02248	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3698674 PMID:17000758^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q640L3	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3835718 PMID:18604197^[13]	IPI: Inferred from Physical Interaction	UniProtKB:B9EKT6 UniProtKB:Q9JKF1	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4441124 PMID:15537656^[14]	IPI: Inferred from Physical Interaction	UniProtKB:P63044	F	From MGI
	GO:0005515	protein binding	MGI:MGI:52805 PMID:8464478^[15]	IPI: Inferred from Physical Interaction	RefSeq:573460	F	From MGI
	GO:0005525	GTP binding	MGI:MGI:3616720 PMID:16510873^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005525	GTP binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	F	From MGI
	GO:0005622	intracellular	MGI:MGI:1929482 PMID:10490598^[3]	TAS: Traceable Author Statement		C	From MGI
	GO:0005622	intracellular	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003578	C	From MGI
	GO:0005622	intracellular	MGI:MGI:3687818 PMID:10954424^[11]	TAS: Traceable Author Statement		C	From MGI
	GO:0005623	cell	MGI:MGI:3580741 PMID:15882626^[16]	IMP: Inferred from Mutant Phenotype		C	From MGI
	GO:0005623	cell	MGI:MGI:3664674 PMID:16892058^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:3574751 PMID:15775979^[18]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4367296 PMID:19796622^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	C	From MGI
	GO:0005856	cytoskeleton	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0206	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	C	From MGI
	GO:0007015	actin filament organization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0007030	Golgi organization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0007088	regulation of mitosis	MGI:MGI:3664674 PMID:16892058^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0007097	nuclear migration	MGI:MGI:3580741 PMID:15882626^[16]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007097	nuclear migration	MGI:MGI:3664674 PMID:16892058^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0007163	establishment or maintenance of cell polarity	MGI:MGI:3687818 PMID:10954424^[11]	TAS: Traceable Author Statement		P	From MGI
	GO:0007264	small GTPase mediated signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001806 InterPro:IPR003578	P	From MGI
	GO:0007266	Rho protein signal transduction	MGI:MGI:1929482 PMID:10490598^[3]	TAS: Traceable Author Statement		P	From MGI
	GO:0007399	nervous system development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0524	P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0010629	negative regulation of gene expression	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016197	endosome transport	MGI:MGI:3687818 PMID:10954424^[11]	TAS: Traceable Author Statement		P	From MGI
	GO:0016337	cell-cell adhesion	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0016337	cell-cell adhesion	MGI:MGI:3687818 PMID:10954424^[11]	TAS: Traceable Author Statement		P	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	F	From MGI
	GO:0030036	actin cytoskeleton organization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	P	From MGI
	GO:0030141	secretory granule	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	C	From MGI
	GO:0030154	cell differentiation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0221	P	From MGI
	GO:0030175	filopodium	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	C	From MGI
	GO:0030496	midbody	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	C	From MGI
	GO:0030742	GTP-dependent protein binding	MGI:MGI:3687818 PMID:10954424^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Z101	F	From MGI
	GO:0031069	hair follicle morphogenesis	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0031274	positive regulation of pseudopodium assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	P	From MGI
	GO:0031333	negative regulation of protein complex assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	P	From MGI
	GO:0031424	keratinization	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0031435	mitogen-activated protein kinase kinase kinase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	F	From MGI
	GO:0031647	regulation of protein stability	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0031996	thioesterase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	F	From MGI
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0034332	adherens junction organization	MGI:MGI:3664674 PMID:16892058^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0034613	cellular protein localization	MGI:MGI:3689461 PMID:16621792^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0035088	establishment or maintenance of apical/basal cell polarity	MGI:MGI:3664674 PMID:16892058^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0035264	multicellular organism growth	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0042176	regulation of protein catabolic process	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0042176	regulation of protein catabolic process	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0042995	cell projection	MGI:MGI:3587490 PMID:15728722^[21]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043005	neuron projection	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	C	From MGI
	GO:0043025	neuronal cell body	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	C	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:3850924 PMID:19244314^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043497	regulation of protein heterodimerization activity	MGI:MGI:3850924 PMID:19244314^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043525	positive regulation of neuron apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	MGI:MGI:3587490 PMID:15728722^[21]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045177	apical part of cell	MGI:MGI:3664674 PMID:16892058^[17]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0045740	positive regulation of DNA replication	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0045859	regulation of protein kinase activity	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0046847	filopodium assembly	MGI:MGI:2447568 PMID:10699171^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048554	positive regulation of metalloenzyme activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0048664	neuron fate determination	MGI:MGI:3664674 PMID:16892058^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0048730	epidermis morphogenesis	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0051017	actin filament bundle assembly	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0051233	spindle midzone	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	C	From MGI
	GO:0051246	regulation of protein metabolic process	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0051489	regulation of filopodium assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	P	From MGI
	GO:0051647	nucleus localization	MGI:MGI:3664674 PMID:16892058^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0051683	establishment of Golgi localization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0051835	positive regulation of synapse structural plasticity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	P	From MGI
	GO:0060047	heart contraction	MGI:MGI:5052204 PMID:21690310^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:97350	P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0060684	epithelial-mesenchymal cell signaling	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0060789	hair follicle placode formation	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0071338	positive regulation of hair follicle cell proliferation	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0071777	positive regulation of cell cycle cytokinesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	P	From MGI
	GO:0071944	cell periphery	MGI:MGI:4367296 PMID:19796622^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0072384	organelle transport along microtubule	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0072686	mitotic spindle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60953	C	From MGI
	GO:0090135	actin filament branching	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
	GO:0090136	epithelial cell-cell adhesion	MGI:MGI:3616720 PMID:16510873^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3619134	P	From MGI
	GO:0090316	positive regulation of intracellular protein transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_741991	P	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20: 571-85 PubMed GONUTS page
↑ ^2.0 ^2.1 Qian L et al. (2011) Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol 193: 1181-96 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Joberty G et al. (1999) The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol 19: 6585-97 PubMed GONUTS page
↑ ^4.0 ^4.1 Prakash SK et al. (2000) Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum Mol Genet 9: 477-88 PubMed GONUTS page
↑ Rossman KL et al. (2003) Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. J Biol Chem 278: 18393-400 PubMed GONUTS page
↑ Gakidis MA et al. (2004) Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol 166: 273-82 PubMed GONUTS page
↑ Chiang SH et al. (2003) TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J 22: 2679-91 PubMed GONUTS page
↑ Nishikimi A et al. (2005) Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. FEBS Lett 579: 1039-46 PubMed GONUTS page
↑ Ryan XP et al. (2005) The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron 47: 85-100 PubMed GONUTS page
↑ Ureña JM et al. (2005) Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain. J Comp Neurol 490: 119-32 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Johansson A et al. (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J Cell Sci 113 ( Pt 18): 3267-75 PubMed GONUTS page
↑ Kostenko EV et al. (2006) Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Mol Cell Biol 26: 8964-75 PubMed GONUTS page
↑ Nojima H et al. (2008) IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat Cell Biol 10: 971-8 PubMed GONUTS page
↑ Nevins AK & Thurmond DC (2005) A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis. J Biol Chem 280: 1944-52 PubMed GONUTS page
↑ Miki T et al. (1993) Oncogene ect2 is related to regulators of small GTP-binding proteins. Nature 362: 462-5 PubMed GONUTS page
↑ ^16.0 ^16.1 Gomes ER et al. (2005) Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Cell 121: 451-63 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 Cappello S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci 9: 1099-107 PubMed GONUTS page
↑ Tunggal JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 24: 1146-56 PubMed GONUTS page
↑ ^19.0 ^19.1 Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
↑ Sharma M et al. (2006) Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. J Biol Chem 281: 17140-9 PubMed GONUTS page
↑ ^21.0 ^21.1 Aoki K et al. (2005) Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell 16: 2207-17 PubMed GONUTS page
↑ ^22.0 ^22.1 Oh JE et al. (2009) Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway. FASEB J 23: 2088-99 PubMed GONUTS page

[PMID:16510873-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20: 571-85 PubMed GONUTS page

[PMID:21690310-1] 2.0 ^2.1 Qian L et al. (2011) Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol 193: 1181-96 PubMed GONUTS page

[PMID:10490598-2] 3.0 ^3.1 ^3.2 ^3.3 Joberty G et al. (1999) The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol 19: 6585-97 PubMed GONUTS page

[PMID:10699171-3] 4.0 ^4.1 Prakash SK et al. (2000) Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum Mol Genet 9: 477-88 PubMed GONUTS page

[PMID:12637522-4] Rossman KL et al. (2003) Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. J Biol Chem 278: 18393-400 PubMed GONUTS page

[PMID:15249579-5] Gakidis MA et al. (2004) Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol 166: 273-82 PubMed GONUTS page

[PMID:12773384-6] Chiang SH et al. (2003) TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J 22: 2679-91 PubMed GONUTS page

[PMID:15710388-7] Nishikimi A et al. (2005) Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. FEBS Lett 579: 1039-46 PubMed GONUTS page

[PMID:15996550-8] Ryan XP et al. (2005) The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron 47: 85-100 PubMed GONUTS page

[PMID:16052498-9] Ureña JM et al. (2005) Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain. J Comp Neurol 490: 119-32 PubMed GONUTS page

[PMID:10954424-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Johansson A et al. (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J Cell Sci 113 ( Pt 18): 3267-75 PubMed GONUTS page

[PMID:17000758-11] Kostenko EV et al. (2006) Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Mol Cell Biol 26: 8964-75 PubMed GONUTS page

[PMID:18604197-12] Nojima H et al. (2008) IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat Cell Biol 10: 971-8 PubMed GONUTS page

[PMID:15537656-13] Nevins AK & Thurmond DC (2005) A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis. J Biol Chem 280: 1944-52 PubMed GONUTS page

[PMID:8464478-14] Miki T et al. (1993) Oncogene ect2 is related to regulators of small GTP-binding proteins. Nature 362: 462-5 PubMed GONUTS page

[PMID:15882626-15] 16.0 ^16.1 Gomes ER et al. (2005) Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Cell 121: 451-63 PubMed GONUTS page

[PMID:16892058-16] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 Cappello S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci 9: 1099-107 PubMed GONUTS page

[PMID:15775979-17] Tunggal JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 24: 1146-56 PubMed GONUTS page

[PMID:19796622-18] 19.0 ^19.1 Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page

[PMID:16621792-19] Sharma M et al. (2006) Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. J Biol Chem 281: 17140-9 PubMed GONUTS page

[PMID:15728722-20] 21.0 ^21.1 Aoki K et al. (2005) Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell 16: 2207-17 PubMed GONUTS page

[PMID:19244314-21] 22.0 ^22.1 Oh JE et al. (2009) Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway. FASEB J 23: 2088-99 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Cdc42
Protein Name(s)	cell division cycle 42 homolog (S. cerevisiae),
External Links
MGI	MGI:106211

MGI:Cdc42

Contents

Annotations

Notes

References

a

b

c

d

e

f

f cont.

g

h

i

k

m

n

o

p

p cont.

r

s

t

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox