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MGI:Cd8a

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Cd8a ( synonyms: Ly-2, Ly-35, Ly-B, Lyt-2 )
Protein Name(s) CD8 antigen, alpha chain,
External Links
MGI MGI:88346

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002456

T cell mediated immunity

MGI:MGI:1933767
PMID:1673361[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857149

P

From MGI

GO:0007166

cell surface receptor signaling pathway

MGI:MGI:893249
PMID:9208839[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1332382
PMID:10072077[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1352309
PMID:10648399[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1354083
PMID:10704459[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1860996
PMID:10943842[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1933767
PMID:1673361[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:2682054
PMID:14609575[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3051177
PMID:15240714[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3054293
PMID:15294943[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3054335
PMID:15322158[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3531056
PMID:15728238[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3576940
PMID:15795238[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3610843
PMID:16287714[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3686949
PMID:16973387[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3708031
PMID:17357106[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3762745
PMID:8688082[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3813999
PMID:17082577[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3817343
PMID:18776904[18]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3818245
PMID:18836449[19]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3829555
PMID:17277142[20]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3834312
PMID:17213291[21]

ISO: Inferred from Sequence Orthology

UniProtKB:P01732

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3839054
PMID:18984740[22]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3849361
PMID:19349303[23]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:4358631
PMID:19723499[24]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:4415096
PMID:19934022[25]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5004747
PMID:21460847[26]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5140640
PMID:21508411[27]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5296987
PMID:22072979[28]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:55958
PMID:6610701[29]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:78866
PMID:8788039[30]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:81771
PMID:8755570[31]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:87442
PMID:7589135[32]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:893249
PMID:9208839[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009986

cell surface

MGI:MGI:2678982
PMID:14568922[33]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P07725

F

From MGI

GO:0042110

T cell activation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P07725

P

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:3576144
PMID:15749886[34]

IDA: Inferred from Direct Assay

F

From MGI

GO:0045065

cytotoxic T cell differentiation

MGI:MGI:1933767
PMID:1673361[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857149

P

From MGI

GO:0050850

positive regulation of calcium-mediated signaling

MGI:MGI:893249
PMID:9208839[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0051607

defense response to virus

MGI:MGI:3829555
PMID:17277142[20]

IDA: Inferred from Direct Assay

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Fung-Leung WP et al. (1991) CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65: 443-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 Wiest DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 6: 663-71 PubMed GONUTS page
  3. Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page
  4. Guerriero A et al. (2000) PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood 95: 879-85 PubMed GONUTS page
  5. Kennedy MK et al. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 191: 771-80 PubMed GONUTS page
  6. Tamura K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102: 221-31 PubMed GONUTS page
  7. Matsuzaki J et al. (2003) Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol 224: 98-105 PubMed GONUTS page
  8. McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page
  9. Kang J et al. (2004) STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol 173: 2307-14 PubMed GONUTS page
  10. García-Martínez LF et al. (2004) A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J Immunol 173: 2995-3001 PubMed GONUTS page
  11. Mandal M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 201: 603-14 PubMed GONUTS page
  12. Winkler IG et al. (2005) Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J Exp Med 201: 1077-88 PubMed GONUTS page
  13. Bultman SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev 19: 2849-61 PubMed GONUTS page
  14. Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-54 PubMed GONUTS page
  15. Ling KW et al. (2007) GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur J Immunol 37: 1043-52 PubMed GONUTS page
  16. Sim BC et al. (1996) Control of MHC restriction by TCR Valpha CDR1 and CDR2. Science 273: 963-6 PubMed GONUTS page
  17. Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol 177: 6650-9 PubMed GONUTS page
  18. Wang L et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol 9: 1122-30 PubMed GONUTS page
  19. Shiow LR et al. (2008) The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol 9: 1307-15 PubMed GONUTS page
  20. 20.0 20.1 Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page
  21. Wilson TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109: 3786-93 PubMed GONUTS page
  22. Dai YD et al. (2009) Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes 58: 156-64 PubMed GONUTS page
  23. Stone EL et al. (2009) Glycosyltransferase function in core 2-type protein O glycosylation. Mol Cell Biol 29: 3770-82 PubMed GONUTS page
  24. Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page
  25. Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med 206: 2987-3000 PubMed GONUTS page
  26. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol 12: 450-9 PubMed GONUTS page
  27. Hu MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood 117: 6120-31 PubMed GONUTS page
  28. Nowell CS et al. (2011) Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet 7: e1002348 PubMed GONUTS page
  29. Davidson WF et al. (1984) Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J Immunol 133: 1048-56 PubMed GONUTS page
  30. Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7: 107-14 PubMed GONUTS page
  31. Bouvier G et al. (1996) Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci U S A 93: 7877-81 PubMed GONUTS page
  32. Simpson SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol 25: 2618-25 PubMed GONUTS page
  33. Kerry SE et al. (2003) Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement. J Immunol 171: 4493-503 PubMed GONUTS page
  34. Attinger A et al. (2005) Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule. J Immunol 174: 3501-7 PubMed GONUTS page
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