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MGI:Cd8a
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cd8a ( synonyms: Ly-2, Ly-35, Ly-B, Lyt-2 ) | |
| Protein Name(s) | CD8 antigen, alpha chain, | |
| External Links | ||
| MGI | MGI:88346 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002456 |
T cell mediated immunity |
MGI:MGI:1933767 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857149 |
P |
From MGI |
||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:893249 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:1332382 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:1352309 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:1354083 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:1860996 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:1933767 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:2682054 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3051177 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3054293 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3054335 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3531056 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3576940 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3610843 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3686949 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3708031 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3762745 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3813999 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3817343 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3818245 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3829555 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3834312 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3839054 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3849361 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4358631 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4415096 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:5004747 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:5140640 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:5296987 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:55958 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:78866 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:81771 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:87442 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:893249 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:2678982 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042110 |
T cell activation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:3576144 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045065 |
cytotoxic T cell differentiation |
MGI:MGI:1933767 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857149 |
P |
From MGI |
||
| GO:0050850 |
positive regulation of calcium-mediated signaling |
MGI:MGI:893249 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051607 |
defense response to virus |
MGI:MGI:3829555 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Fung-Leung WP et al. (1991) CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65: 443-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Wiest DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 6: 663-71 PubMed GONUTS page
- ↑ Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page
- ↑ Guerriero A et al. (2000) PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood 95: 879-85 PubMed GONUTS page
- ↑ Kennedy MK et al. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 191: 771-80 PubMed GONUTS page
- ↑ Tamura K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102: 221-31 PubMed GONUTS page
- ↑ Matsuzaki J et al. (2003) Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol 224: 98-105 PubMed GONUTS page
- ↑ McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page
- ↑ Kang J et al. (2004) STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol 173: 2307-14 PubMed GONUTS page
- ↑ García-Martínez LF et al. (2004) A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J Immunol 173: 2995-3001 PubMed GONUTS page
- ↑ Mandal M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 201: 603-14 PubMed GONUTS page
- ↑ Winkler IG et al. (2005) Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J Exp Med 201: 1077-88 PubMed GONUTS page
- ↑ Bultman SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev 19: 2849-61 PubMed GONUTS page
- ↑ Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-54 PubMed GONUTS page
- ↑ Ling KW et al. (2007) GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur J Immunol 37: 1043-52 PubMed GONUTS page
- ↑ Sim BC et al. (1996) Control of MHC restriction by TCR Valpha CDR1 and CDR2. Science 273: 963-6 PubMed GONUTS page
- ↑ Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol 177: 6650-9 PubMed GONUTS page
- ↑ Wang L et al. (2008) Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol 9: 1122-30 PubMed GONUTS page
- ↑ Shiow LR et al. (2008) The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol 9: 1307-15 PubMed GONUTS page
- ↑ 20.0 20.1 Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page
- ↑ Wilson TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109: 3786-93 PubMed GONUTS page
- ↑ Dai YD et al. (2009) Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes 58: 156-64 PubMed GONUTS page
- ↑ Stone EL et al. (2009) Glycosyltransferase function in core 2-type protein O glycosylation. Mol Cell Biol 29: 3770-82 PubMed GONUTS page
- ↑ Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page
- ↑ Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med 206: 2987-3000 PubMed GONUTS page
- ↑ Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol 12: 450-9 PubMed GONUTS page
- ↑ Hu MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood 117: 6120-31 PubMed GONUTS page
- ↑ Nowell CS et al. (2011) Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet 7: e1002348 PubMed GONUTS page
- ↑ Davidson WF et al. (1984) Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J Immunol 133: 1048-56 PubMed GONUTS page
- ↑ Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7: 107-14 PubMed GONUTS page
- ↑ Bouvier G et al. (1996) Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci U S A 93: 7877-81 PubMed GONUTS page
- ↑ Simpson SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol 25: 2618-25 PubMed GONUTS page
- ↑ Kerry SE et al. (2003) Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement. J Immunol 171: 4493-503 PubMed GONUTS page
- ↑ Attinger A et al. (2005) Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule. J Immunol 174: 3501-7 PubMed GONUTS page