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MGI:Cd40lg
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cd40lg ( synonyms: CD154, Cd40L, gp39, HIGM1, IMD3, Ly-62, T-BAM, Tnfsf5 ) | |
| Protein Name(s) | CD40 ligand, | |
| External Links | ||
| MGI | MGI:88337 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002839 |
positive regulation of immune response to tumor cell |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445805 |
P |
From MGI |
||
| GO:0005125 |
cytokine activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0202 |
F |
From MGI |
||
| GO:0005164 |
tumor necrosis factor receptor binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005174 |
CD40 receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445805 |
C |
From MGI |
||
| GO:0005623 |
cell |
MGI:MGI:3510272 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1344376 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:3687427 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3813999 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0030168 |
platelet activation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030183 |
B cell differentiation |
MGI:MGI:3028360 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96556 |
P |
From MGI |
||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445805 |
P |
From MGI |
||
| GO:0032729 |
positive regulation of interferon-gamma production |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445805 |
P |
From MGI |
||
| GO:0032733 |
positive regulation of interleukin-10 production |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445805 |
P |
From MGI |
||
| GO:0032735 |
positive regulation of interleukin-12 production |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445805 |
P |
From MGI |
||
| GO:0032735 |
positive regulation of interleukin-12 production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042100 |
B cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045190 |
isotype switching |
MGI:MGI:3687427 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045348 |
positive regulation of MHC class II biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445805 |
P |
From MGI |
||
| GO:0048305 |
immunoglobulin secretion |
MGI:MGI:3510272 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1344376 |
P |
From MGI |
||
| GO:0051023 |
regulation of immunoglobulin secretion |
MGI:MGI:2680840 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0097028 |
dendritic cell differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445805 |
P |
From MGI |
||
| GO:2000353 |
positive regulation of endothelial cell apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Qian Y et al. (2004) Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity 21: 575-87 PubMed GONUTS page
- ↑ 2.0 2.1 Snapper CM et al. (1995) Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells. A redefinition of the TI-2 vs T cell-dependent antigen dichotomy. J Immunol 154: 1177-87 PubMed GONUTS page
- ↑ Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol 177: 6650-9 PubMed GONUTS page
- ↑ Hasbold J et al. (2004) Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation. Nat Immunol 5: 55-63 PubMed GONUTS page
- ↑ Hostager BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem 278: 45382-90 PubMed GONUTS page
