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MGI:Cd40
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cd40 ( synonyms: Bp50, Cd40, p50, Tnfrsf5 ) | |
| Protein Name(s) | CD40 antigen, | |
| External Links | ||
| MGI | MGI:88336 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002768 |
immune response-regulating cell surface receptor signaling pathway |
MGI:MGI:3051177 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:4462284 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5002402 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:84147 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_599187 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:4462284 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006874 |
cellular calcium ion homeostasis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006874 |
cellular calcium ion homeostasis |
MGI:MGI:5306543 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_599187 |
P |
From MGI |
||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:1889695 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:2679172 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3051177 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3829555 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:77753 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_599187 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0019899 |
enzyme binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:1889695 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:2176424 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:3610855 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:87891 |
P |
From MGI |
||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:3619310 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:3757615 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:80946 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032735 |
positive regulation of interleukin-12 production |
MGI:MGI:3051177 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032855 |
positive regulation of Rac GTPase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035631 |
CD40 receptor complex |
MGI:MGI:4462284 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042113 |
B cell activation |
MGI:MGI:3027169 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042511 |
positive regulation of tyrosine phosphorylation of Stat1 protein |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043089 |
positive regulation of Cdc42 GTPase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043231 |
intracellular membrane-bounded organelle |
MGI:MGI:3690603 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043406 |
positive regulation of MAP kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048304 |
positive regulation of isotype switching to IgG isotypes |
MGI:MGI:2670820 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050776 |
regulation of immune response |
MGI:MGI:2670820 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051023 |
regulation of immunoglobulin secretion |
MGI:MGI:2680840 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051607 |
defense response to virus |
MGI:MGI:3829555 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0090037 |
positive regulation of protein kinase C signaling cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000353 |
positive regulation of endothelial cell apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Hostager BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One 5: e11380 PubMed GONUTS page
- ↑ Liu X et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12: 416-24 PubMed GONUTS page
- ↑ Ishida T et al. (1996) Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem 271: 28745-8 PubMed GONUTS page
- ↑ Kim DY et al. (2011) Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L. J Neuroinflammation 8: 25 PubMed GONUTS page
- ↑ 6.0 6.1 Sexl V et al. (2000) Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood 96: 2277-83 PubMed GONUTS page
- ↑ Pauleau AL & Murray PJ (2003) Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol 23: 7531-9 PubMed GONUTS page
- ↑ 8.0 8.1 Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page
- ↑ Kong YY et al. (1995) Differential requirements of CD45 for lymphocyte development and function. Eur J Immunol 25: 3431-6 PubMed GONUTS page
- ↑ Chin AI et al. (2002) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416: 190-4 PubMed GONUTS page
- ↑ Skok M et al. (2005) Nicotinic receptors regulate B lymphocyte activation and immune response. Eur J Pharmacol 517: 246-51 PubMed GONUTS page
- ↑ Aldrich MB et al. (2003) Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol 171: 5562-70 PubMed GONUTS page
- ↑ Chappel MS et al. (1996) Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J Exp Med 184: 1639-49 PubMed GONUTS page
- ↑ Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med 183: 1707-18 PubMed GONUTS page
- ↑ Merluzzi S et al. (2004) CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism. J Biol Chem 279: 1777-86 PubMed GONUTS page
- ↑ Chen W et al. (2006) Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol 36: 1598-607 PubMed GONUTS page
- ↑ 17.0 17.1 Gerth AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int Immunol 15: 937-44 PubMed GONUTS page
- ↑ Hostager BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem 278: 45382-90 PubMed GONUTS page
