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MGI:Cd4

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Cd4 ( synonyms: L3T4, Ly-4 )
Protein Name(s) CD4 antigen,
External Links
MGI MGI:88335

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001816

cytokine production

MGI:MGI:68932
PMID:7930593[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:1891436

P

From MGI

GO:0001816

cytokine production

MGI:MGI:68932
PMID:7930593[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857281

P

From MGI

GO:0001948

glycoprotein binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

F

From MGI

GO:0005788

endoplasmic reticulum lumen

MGI:MGI:3611991
PMID:16223484[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005789

endoplasmic reticulum membrane

MGI:MGI:3611991
PMID:16223484[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:2683997
PMID:14517216[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0006948

induction by virus of host cell-cell fusion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

P

From MGI

GO:0006955

immune response

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000973

P

From MGI

GO:0007155

cell adhesion

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008424

P

From MGI

GO:0007166

cell surface receptor signaling pathway

MGI:MGI:893249
PMID:9208839[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008270

zinc ion binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

F

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1332382
PMID:10072077[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1354083
PMID:10704459[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1860996
PMID:10943842[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:2429474
PMID:12421911[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:2682054
PMID:14609575[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3052401
PMID:15368291[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3054335
PMID:15322158[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3531056
PMID:15728238[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3576940
PMID:15795238[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3610843
PMID:16287714[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3686949
PMID:16973387[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3708031
PMID:17357106[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3803061
PMID:18641307[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3813999
PMID:17082577[18]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3817343
PMID:18776904[19]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3818206
PMID:19008373[20]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3818245
PMID:18836449[21]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3834312
PMID:17213291[22]

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3849361
PMID:19349303[23]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:4358631
PMID:19723499[24]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:4415096
PMID:19934022[25]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:4454353
PMID:20399120[26]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:4838368
PMID:20706986[27]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5004747
PMID:21460847[28]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5140640
PMID:21508411[29]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5296987
PMID:22072979[30]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:62368
PMID:7688139[31]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:75253
PMID:7630421[32]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:77314
PMID:7477352[33]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:77315
PMID:7477353[34]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:77677
PMID:8524870[35]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:78866
PMID:8788039[36]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:81771
PMID:8755570[37]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:82508
PMID:8769481[38]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:87097
PMID:9133426[39]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:87442
PMID:7589135[40]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:893249
PMID:9208839[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009986

cell surface

MGI:MGI:3769991
PMID:8612131[41]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016020

membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000973

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008424

C

From MGI

GO:0019899

enzyme binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

F

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P05540

F

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

F

From MGI

GO:0030217

T cell differentiation

MGI:MGI:3687440
PMID:1533274[42]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P01730

P

From MGI

GO:0030217

T cell differentiation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

P

From MGI

GO:0032507

maintenance of protein location in cell

MGI:MGI:3041758
PMID:15128768[43]

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

P

From MGI

GO:0042110

T cell activation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P05540

P

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

F

From MGI

GO:0045058

T cell selection

MGI:MGI:1194481
PMID:9551897[44]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P01730

P

From MGI

GO:0045058

T cell selection

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

P

From MGI

GO:0045121

membrane raft

MGI:MGI:3041758
PMID:15128768[43]

IDA: Inferred from Direct Assay

C

From MGI

GO:0045234

protein palmitoleylation

MGI:MGI:3041758
PMID:15128768[43]

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

P

From MGI

GO:0045860

positive regulation of protein kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

P

From MGI

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

MGI:MGI:893249
PMID:9208839[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050829

defense response to Gram-negative bacterium

MGI:MGI:2683356
PMID:14688352[45]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857281

P

From MGI

GO:0050850

positive regulation of calcium-mediated signaling

MGI:MGI:893249
PMID:9208839[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050863

regulation of T cell activation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01730

P

From MGI

GO:0050870

positive regulation of T cell activation

MGI:MGI:2429474
PMID:12421911[8]

IDA: Inferred from Direct Assay

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
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  2. 2.0 2.1 Lidén M et al. (2005) The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function. Exp Cell Res 311: 205-17 PubMed GONUTS page
  3. Suzuki M et al. (2003) Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem 278: 51448-53 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Wiest DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 6: 663-71 PubMed GONUTS page
  5. Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page
  6. Kennedy MK et al. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 191: 771-80 PubMed GONUTS page
  7. Tamura K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102: 221-31 PubMed GONUTS page
  8. 8.0 8.1 Workman CJ et al. (2002) Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J Immunol 169: 5392-5 PubMed GONUTS page
  9. Matsuzaki J et al. (2003) Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol 224: 98-105 PubMed GONUTS page
  10. Ye Q et al. (2004) BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol 34: 2750-9 PubMed GONUTS page
  11. García-Martínez LF et al. (2004) A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J Immunol 173: 2995-3001 PubMed GONUTS page
  12. Mandal M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 201: 603-14 PubMed GONUTS page
  13. Winkler IG et al. (2005) Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J Exp Med 201: 1077-88 PubMed GONUTS page
  14. Bultman SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev 19: 2849-61 PubMed GONUTS page
  15. Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-54 PubMed GONUTS page
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  20. Abe J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol 173: 1682-92 PubMed GONUTS page
  21. Shiow LR et al. (2008) The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol 9: 1307-15 PubMed GONUTS page
  22. Wilson TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109: 3786-93 PubMed GONUTS page
  23. Stone EL et al. (2009) Glycosyltransferase function in core 2-type protein O glycosylation. Mol Cell Biol 29: 3770-82 PubMed GONUTS page
  24. Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page
  25. Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med 206: 2987-3000 PubMed GONUTS page
  26. Yagi R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32: 507-17 PubMed GONUTS page
  27. Wang L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur J Immunol 40: 2385-90 PubMed GONUTS page
  28. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol 12: 450-9 PubMed GONUTS page
  29. Hu MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood 117: 6120-31 PubMed GONUTS page
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  33. Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378: 298-302 PubMed GONUTS page
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  36. Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7: 107-14 PubMed GONUTS page
  37. Bouvier G et al. (1996) Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci U S A 93: 7877-81 PubMed GONUTS page
  38. Hazenbos WL et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5: 181-8 PubMed GONUTS page
  39. Mendiratta SK et al. (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6: 469-77 PubMed GONUTS page
  40. Simpson SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol 25: 2618-25 PubMed GONUTS page
  41. Sant'Angelo DB et al. (1996) The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4: 367-76 PubMed GONUTS page
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  43. 43.0 43.1 43.2 Balamuth F et al. (2004) CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J Immunol 172: 5887-92 PubMed GONUTS page
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  45. Bry L & Brenner MB (2004) Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172: 433-41 PubMed GONUTS page
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