MGI:Cd3e

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001772	immunological synapse	MGI:MGI:3041667 PMID:15064761^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0001772	immunological synapse	MGI:MGI:3044274 PMID:14635057^[2]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0002669	positive regulation of T cell anergy	MGI:MGI:3038342 PMID:14973438^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:75253 PMID:7630421^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004888	transmembrane signaling receptor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003110	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3047098 PMID:11390434^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P29020	F	From MGI
	GO:0005515	protein binding	MGI:MGI:66781 PMID:8196616^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P39688 UniProtKB:P43404	F	From MGI
	GO:0005886	plasma membrane	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P07766	C	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003110	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:3757616 PMID:8943715^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:75253 PMID:7630421^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007584	response to nutrient	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101610	P	From MGI
	GO:0008624	induction of apoptosis by extracellular signals	MGI:MGI:80946 PMID:8666928^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:1332382 PMID:10072077^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P07766	C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:3052401 PMID:15368291^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:3577956 PMID:10485657^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:3829555 PMID:17277142^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:3834312 PMID:17213291^[13]	ISO: Inferred from Sequence Orthology	UniProtKB:P07766	C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:4822501 PMID:20660734^[14]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:65397 PMID:8125140^[15]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:75253 PMID:7630421^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:80946 PMID:8666928^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:81771 PMID:8755570^[16]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016020	membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003110	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0017124	SH3 domain binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07766	F	From MGI
	GO:0032729	positive regulation of interferon-gamma production	MGI:MGI:2176424 PMID:11894097^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032753	positive regulation of interleukin-4 production	MGI:MGI:2176424 PMID:11894097^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042101	T cell receptor complex	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P07766	C	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:1332382 PMID:10072077^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:3052401 PMID:15368291^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:3577956 PMID:10485657^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:3822044 PMID:12874832^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001101610	P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07766	P	From MGI
	GO:0042105	alpha-beta T cell receptor complex	MGI:MGI:82729 PMID:9064344^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0042105	alpha-beta T cell receptor complex	MGI:MGI:893249 PMID:9208839^[20]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0045060	negative thymic T cell selection	MGI:MGI:75253 PMID:7630421^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045086	positive regulation of interleukin-2 biosynthetic process	MGI:MGI:3822044 PMID:12874832^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045879	negative regulation of smoothened signaling pathway	MGI:MGI:1888832 PMID:10981962^[21]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046641	positive regulation of alpha-beta T cell proliferation	MGI:MGI:2176424 PMID:11894097^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046641	positive regulation of alpha-beta T cell proliferation	MGI:MGI:3038342 PMID:14973438^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046641	positive regulation of alpha-beta T cell proliferation	MGI:MGI:65397 PMID:8125140^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046649	lymphocyte activation	MGI:MGI:3578441 PMID:15843560^[22]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07766	F	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:3577956 PMID:10485657^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050850	positive regulation of calcium-mediated signaling	MGI:MGI:3757616 PMID:8943715^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050850	positive regulation of calcium-mediated signaling	MGI:MGI:75253 PMID:7630421^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050852	T cell receptor signaling pathway	MGI:MGI:3577956 PMID:10485657^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050870	positive regulation of T cell activation	MGI:MGI:3822044 PMID:12874832^[18]	IDA: Inferred from Direct Assay		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Jacobelli J et al. (2004) A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nat Immunol 5: 531-8 PubMed GONUTS page
↑ Garcia GG & Miller RA (2003) Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase. Eur J Immunol 33: 3464-72 PubMed GONUTS page
↑ ^3.0 ^3.1 Heissmeyer V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 5: 255-65 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Negishi I et al. (1995) Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376: 435-8 PubMed GONUTS page
↑ Kirchgessner H et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med 193: 1269-84 PubMed GONUTS page
↑ Gauen LK et al. (1994) Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol 14: 3729-41 PubMed GONUTS page
↑ ^7.0 ^7.1 Hitsumoto Y et al. (1996) Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen. Immunology 89: 200-4 PubMed GONUTS page
↑ ^8.0 ^8.1 Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med 183: 1707-18 PubMed GONUTS page
↑ ^9.0 ^9.1 Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page
↑ ^10.0 ^10.1 Ye Q et al. (2004) BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol 34: 2750-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Moriggl R et al. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11: 225-30 PubMed GONUTS page
↑ Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page
↑ Wilson TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109: 3786-93 PubMed GONUTS page
↑ O'Connell RM et al. (2010) MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci U S A 107: 14235-40 PubMed GONUTS page
↑ ^15.0 ^15.1 Hubbe M & Altevogt P (1994) Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur J Immunol 24: 731-7 PubMed GONUTS page
↑ Bouvier G et al. (1996) Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci U S A 93: 7877-81 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Chin AI et al. (2002) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416: 190-4 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Butler JJ et al. (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J Cell Biochem 89: 975-91 PubMed GONUTS page
↑ Pani G et al. (1996) Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med 184: 839-52 PubMed GONUTS page
↑ Wiest DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 6: 663-71 PubMed GONUTS page
↑ Outram SV et al. (2000) Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity 13: 187-97 PubMed GONUTS page
↑ Zhu M et al. (2005) Negative regulation of lymphocyte activation by the adaptor protein LAX. J Immunol 174: 5612-9 PubMed GONUTS page

[PMID:15064761-0] Jacobelli J et al. (2004) A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nat Immunol 5: 531-8 PubMed GONUTS page

[PMID:14635057-1] Garcia GG & Miller RA (2003) Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase. Eur J Immunol 33: 3464-72 PubMed GONUTS page

[PMID:14973438-2] 3.0 ^3.1 Heissmeyer V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 5: 255-65 PubMed GONUTS page

[PMID:7630421-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Negishi I et al. (1995) Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376: 435-8 PubMed GONUTS page

[PMID:11390434-4] Kirchgessner H et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med 193: 1269-84 PubMed GONUTS page

[PMID:8196616-5] Gauen LK et al. (1994) Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol 14: 3729-41 PubMed GONUTS page

[PMID:8943715-6] 7.0 ^7.1 Hitsumoto Y et al. (1996) Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen. Immunology 89: 200-4 PubMed GONUTS page

[PMID:8666928-7] 8.0 ^8.1 Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med 183: 1707-18 PubMed GONUTS page

[PMID:10072077-8] 9.0 ^9.1 Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page

[PMID:15368291-9] 10.0 ^10.1 Ye Q et al. (2004) BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol 34: 2750-9 PubMed GONUTS page

[PMID:10485657-10] 11.0 ^11.1 ^11.2 ^11.3 Moriggl R et al. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11: 225-30 PubMed GONUTS page

[PMID:17277142-11] Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page

[PMID:17213291-12] Wilson TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109: 3786-93 PubMed GONUTS page

[PMID:20660734-13] O'Connell RM et al. (2010) MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci U S A 107: 14235-40 PubMed GONUTS page

[PMID:8125140-14] 15.0 ^15.1 Hubbe M & Altevogt P (1994) Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur J Immunol 24: 731-7 PubMed GONUTS page

[PMID:8755570-15] Bouvier G et al. (1996) Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci U S A 93: 7877-81 PubMed GONUTS page

[PMID:11894097-16] 17.0 ^17.1 ^17.2 Chin AI et al. (2002) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416: 190-4 PubMed GONUTS page

[PMID:12874832-17] 18.0 ^18.1 ^18.2 Butler JJ et al. (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J Cell Biochem 89: 975-91 PubMed GONUTS page

[PMID:9064344-18] Pani G et al. (1996) Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med 184: 839-52 PubMed GONUTS page

[PMID:9208839-19] Wiest DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 6: 663-71 PubMed GONUTS page

[PMID:10981962-20] Outram SV et al. (2000) Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity 13: 187-97 PubMed GONUTS page

[PMID:15843560-21] Zhu M et al. (2005) Negative regulation of lymphocyte activation by the adaptor protein LAX. J Immunol 174: 5612-9 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Cd3e ( synonyms: CD3, CD3epsilon, T3e )
Protein Name(s)	CD3 antigen, epsilon polypeptide,
External Links
MGI	MGI:88332

MGI:Cd3e

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