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MGI:Cd28
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cd28 | |
| Protein Name(s) | CD28 antigen, | |
| External Links | ||
| MGI | MGI:88327 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002020 |
protease binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0002863 |
positive regulation of inflammatory response to antigenic stimulus |
MGI:MGI:3706650 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857150 |
P |
From MGI |
||
| GO:0005070 |
SH3/SH2 adaptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0008624 |
induction of apoptosis by extracellular signals |
MGI:MGI:1340173 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3822044 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:62368 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857150 |
C |
From MGI |
||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:65397 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:73884 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009967 |
positive regulation of signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031295 |
T cell costimulation |
MGI:MGI:1340173 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031295 |
T cell costimulation |
MGI:MGI:2671029 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031295 |
T cell costimulation |
MGI:MGI:3051152 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031295 |
T cell costimulation |
MGI:MGI:3757614 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031295 |
T cell costimulation |
MGI:MGI:3757614 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857150 |
P |
From MGI |
||
| GO:0031295 |
T cell costimulation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031295 |
T cell costimulation |
MGI:MGI:62368 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857150 |
P |
From MGI |
||
| GO:0031295 |
T cell costimulation |
MGI:MGI:65397 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:2671029 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:3039643 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:3051152 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:3706650 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857150 |
P |
From MGI |
||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:62368 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857150 |
P |
From MGI |
||
| GO:0042110 |
T cell activation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045060 |
negative thymic T cell selection |
MGI:MGI:1340173 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857150 |
P |
From MGI |
||
| GO:0045066 |
regulatory T cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045086 |
positive regulation of interleukin-2 biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045086 |
positive regulation of interleukin-2 biosynthetic process |
MGI:MGI:62368 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857150 |
P |
From MGI |
||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045840 |
positive regulation of mitosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3808092 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1929913 |
P |
From MGI |
||
| GO:0046641 |
positive regulation of alpha-beta T cell proliferation |
MGI:MGI:3038342 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046641 |
positive regulation of alpha-beta T cell proliferation |
MGI:MGI:3757614 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046641 |
positive regulation of alpha-beta T cell proliferation |
MGI:MGI:3757614 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857150 |
P |
From MGI |
||
| GO:0046641 |
positive regulation of alpha-beta T cell proliferation |
MGI:MGI:65397 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048304 |
positive regulation of isotype switching to IgG isotypes |
MGI:MGI:62368 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857150 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Bai XF et al. (2000) The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis. J Clin Invest 105: 1227-32 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kishimoto H & Sprent J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J Exp Med 190: 65-73 PubMed GONUTS page
- ↑ Butler JJ et al. (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J Cell Biochem 89: 975-91 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Shahinian A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261: 609-12 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Hubbe M & Altevogt P (1994) Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur J Immunol 24: 731-7 PubMed GONUTS page
- ↑ Sperling AI et al. (1995) CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J Exp Med 182: 139-46 PubMed GONUTS page
- ↑ 7.0 7.1 Suh WK et al. (2003) The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol 4: 899-906 PubMed GONUTS page
- ↑ 8.0 8.1 Ng LG et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 173: 807-17 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Zhou Q et al. (1997) Homotypic interaction of the heat-stable antigen is not responsible for its co-stimulatory activity for T cell clonal expansion. Eur J Immunol 27: 2524-8 PubMed GONUTS page
- ↑ Egawa T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol 13: 1252-8 PubMed GONUTS page
- ↑ Cismasiu VB et al. (2006) BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. Blood 108: 2695-702 PubMed GONUTS page
- ↑ Heissmeyer V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 5: 255-65 PubMed GONUTS page
