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MGI:Cd2

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Cd2 ( synonyms: LFA-2, Ly-37, Ly37 )
Protein Name(s) CD2 antigen,
External Links
MGI MGI:88320

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001948

glycoprotein binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

F

From MGI

GO:0003823

antigen binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

F

From MGI

GO:0004872

receptor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR015631

F

From MGI

GO:0005515

protein binding

MGI:MGI:51393
PMID:1383383[1]

IPI: Inferred from Physical Interaction

UniProtKB:P18181

F

From MGI

GO:0005576

extracellular region

MGI:MGI:51393
PMID:1383383[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0007155

cell adhesion

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

From MGI

GO:0007155

cell adhesion

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008424

P

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3822044
PMID:12874832[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5004747
PMID:21460847[3]

ISO: Inferred from Sequence Orthology

UniProtKB:P06729

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:65397
PMID:8125140[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009898

internal side of plasma membrane

MGI:MGI:51393
PMID:1383383[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009986

cell surface

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

C

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008424
InterPro:IPR015631

C

From MGI

GO:0016337

cell-cell adhesion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

P

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

F

From MGI

GO:0030971

receptor tyrosine kinase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

F

From MGI

GO:0042110

T cell activation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

P

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

F

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:51393
PMID:1383383[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0043234

protein complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

C

From MGI

GO:0043499

eukaryotic cell surface binding

MGI:MGI:51393
PMID:1383383[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0043499

eukaryotic cell surface binding

MGI:MGI:51393
PMID:1383383[1]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0043621

protein self-association

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

F

From MGI

GO:0045121

membrane raft

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P08921

C

From MGI

GO:0046658

anchored to plasma membrane

MGI:MGI:51393
PMID:1383383[1]

IDA: Inferred from Direct Assay

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Kato K et al. (1992) CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J Exp Med 176: 1241-9 PubMed GONUTS page
  2. Butler JJ et al. (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J Cell Biochem 89: 975-91 PubMed GONUTS page
  3. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol 12: 450-9 PubMed GONUTS page
  4. Hubbe M & Altevogt P (1994) Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur J Immunol 24: 731-7 PubMed GONUTS page
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