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MGI:Ccl3

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Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ccl3 ( synonyms: CCL3, G0S19-1, LD78alpha, macrophage inflammatory protein-1alpha, MIP-1 alpha, MIP-1alpha, MIP1-(a), MIP1-alpha, Mip1a, Scya3 )
Protein Name(s) chemokine (C-C motif) ligand 3,
External Links
MGI MGI:98260

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000165

MAPK cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0001775

cell activation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0002548

monocyte chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0004672

protein kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0004698

calcium-dependent protein kinase C activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0005125

cytokine activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0202

F

From MGI

GO:0005515

protein binding

MGI:MGI:77397
PMID:7594543[1]

IPI: Inferred from Physical Interaction

UniProtKB:P51675

F

From MGI

GO:0005515

protein binding

MGI:MGI:77397
PMID:7594543[1]

IPI: Inferred from Physical Interaction

UniProtKB:P51678

F

From MGI

GO:0005515

protein binding

MGI:MGI:87663
PMID:9139699[2]

IPI: Inferred from Physical Interaction

UniProtKB:O08707

F

From MGI

GO:0005576

extracellular region

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

C

From MGI

GO:0005615

extracellular space

MGI:MGI:3839525
PMID:19139201[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

C

From MGI

GO:0005622

intracellular

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

C

From MGI

GO:0005829

cytosol

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

C

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006816

calcium ion transport

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006874

cellular calcium ion homeostasis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006887

exocytosis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006935

chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006954

inflammatory response

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006955

immune response

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000827
InterPro:IPR001811

P

From MGI

GO:0007010

cytoskeleton organization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0007204

elevation of cytosolic calcium ion concentration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P50229

P

From MGI

GO:0007267

cell-cell signaling

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0007610

behavior

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0008009

chemokine activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P50229

F

From MGI

GO:0008009

chemokine activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0008009

chemokine activity

MGI:MGI:77397
PMID:7594543[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0008360

regulation of cell shape

MGI:MGI:3044466
PMID:15155903[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008360

regulation of cell shape

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0009636

response to toxin

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0010628

positive regulation of gene expression

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0010629

negative regulation of gene expression

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0010818

T cell chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0014808

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0016004

phospholipase activator activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0016301

kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0016310

phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0019722

calcium-mediated signaling

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0030335

positive regulation of cell migration

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0030502

negative regulation of bone mineralization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0030593

neutrophil chemotaxis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P50229

P

From MGI

GO:0030593

neutrophil chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0030595

leukocyte chemotaxis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P50229

P

From MGI

GO:0031663

lipopolysaccharide-mediated signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0031726

CCR1 chemokine receptor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0031730

CCR5 chemokine receptor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0032760

positive regulation of tumor necrosis factor production

MGI:MGI:5301204
PMID:21784977[5]

IGI: Inferred from Genetic Interaction

UniProtKB:P22893

P

From MGI

GO:0042056

chemoattractant activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0043085

positive regulation of catalytic activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0043308

eosinophil degranulation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0043491

protein kinase B signaling cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0043525

positive regulation of neuron apoptotic process

MGI:MGI:3044466
PMID:15155903[4]

IGI: Inferred from Genetic Interaction

UniProtKB:P20060

P

From MGI

GO:0043615

astrocyte cell migration

MGI:MGI:3044466
PMID:15155903[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043922

negative regulation by host of viral transcription

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0045671

negative regulation of osteoclast differentiation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0045672

positive regulation of osteoclast differentiation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P50229

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3044466
PMID:15155903[4]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0048245

eosinophil chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0048246

macrophage chemotaxis

MGI:MGI:5301204
PMID:21784977[5]

IGI: Inferred from Genetic Interaction

UniProtKB:P22893

P

From MGI

GO:0048247

lymphocyte chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0050718

positive regulation of interleukin-1 beta secretion

MGI:MGI:5301204
PMID:21784977[5]

IGI: Inferred from Genetic Interaction

UniProtKB:P22893

P

From MGI

GO:0050729

positive regulation of inflammatory response

MGI:MGI:5301204
PMID:21784977[5]

IGI: Inferred from Genetic Interaction

UniProtKB:P22893

P

From MGI

GO:0050850

positive regulation of calcium-mediated signaling

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0050918

positive chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0051928

positive regulation of calcium ion transport

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0051930

regulation of sensory perception of pain

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0070374

positive regulation of ERK1 and ERK2 cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0070723

response to cholesterol

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0071407

cellular response to organic cyclic compound

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0071621

granulocyte chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:2000503

positive regulation of natural killer cell chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Post, TW et al. (1995) Molecular characterization of two murine eosinophil beta chemokine receptors. J. Immunol. 155 5299-305 PubMed GONUTS page
  2. Nibbs, RJ et al. (1997) Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J. Biol. Chem. 272 12495-504 PubMed GONUTS page
  3. Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Wu, YP & Proia, RL (2004) Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease mice. Proc. Natl. Acad. Sci. U.S.A. 101 8425-30 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Kang, JG et al. (2011) Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. J. Immunol. 187 2696-701 PubMed GONUTS page
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