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It is now the 6th OPEN Period for CACAO Spring 2018! It will end on Monday April 23, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

It is now the 4th OPEN Period for CACAO Phage Hunters 2018! It will end on Sunday April 22, 2018 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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MGI:Ccl3

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Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ccl3 ( synonyms: CCL3, G0S19-1, LD78alpha, macrophage inflammatory protein-1alpha, MIP-1 alpha, MIP-1alpha, MIP1-(a), MIP1-alpha, Mip1a, Scya3 )
Protein Name(s) chemokine (C-C motif) ligand 3,
External Links
MGI MGI:98260

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000165

MAPK cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0001775

cell activation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0002548

monocyte chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0004672

protein kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0004698

calcium-dependent protein kinase C activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0005125

cytokine activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0202

F

From MGI

GO:0005515

protein binding

MGI:MGI:77397
PMID:7594543[1]

IPI: Inferred from Physical Interaction

UniProtKB:P51675

F

From MGI

GO:0005515

protein binding

MGI:MGI:77397
PMID:7594543[1]

IPI: Inferred from Physical Interaction

UniProtKB:P51678

F

From MGI

GO:0005515

protein binding

MGI:MGI:87663
PMID:9139699[2]

IPI: Inferred from Physical Interaction

UniProtKB:O08707

F

From MGI

GO:0005576

extracellular region

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

C

From MGI

GO:0005615

extracellular space

MGI:MGI:3839525
PMID:19139201[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

C

From MGI

GO:0005622

intracellular

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

C

From MGI

GO:0005829

cytosol

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

C

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006816

calcium ion transport

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006874

cellular calcium ion homeostasis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006887

exocytosis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006935

chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006954

inflammatory response

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0006955

immune response

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000827
InterPro:IPR001811

P

From MGI

GO:0007010

cytoskeleton organization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0007204

elevation of cytosolic calcium ion concentration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P50229

P

From MGI

GO:0007267

cell-cell signaling

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0007610

behavior

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0008009

chemokine activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P50229

F

From MGI

GO:0008009

chemokine activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0008009

chemokine activity

MGI:MGI:77397
PMID:7594543[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0008360

regulation of cell shape

MGI:MGI:3044466
PMID:15155903[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008360

regulation of cell shape

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0009636

response to toxin

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0010628

positive regulation of gene expression

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0010629

negative regulation of gene expression

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0010818

T cell chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0014808

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0016004

phospholipase activator activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0016301

kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0016310

phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0019722

calcium-mediated signaling

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0030335

positive regulation of cell migration

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0030502

negative regulation of bone mineralization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0030593

neutrophil chemotaxis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P50229

P

From MGI

GO:0030593

neutrophil chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0030595

leukocyte chemotaxis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P50229

P

From MGI

GO:0031663

lipopolysaccharide-mediated signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0031726

CCR1 chemokine receptor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0031730

CCR5 chemokine receptor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0032760

positive regulation of tumor necrosis factor production

MGI:MGI:5301204
PMID:21784977[5]

IGI: Inferred from Genetic Interaction

UniProtKB:P22893

P

From MGI

GO:0042056

chemoattractant activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

F

From MGI

GO:0043085

positive regulation of catalytic activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0043308

eosinophil degranulation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0043491

protein kinase B signaling cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0043525

positive regulation of neuron apoptotic process

MGI:MGI:3044466
PMID:15155903[4]

IGI: Inferred from Genetic Interaction

UniProtKB:P20060

P

From MGI

GO:0043615

astrocyte cell migration

MGI:MGI:3044466
PMID:15155903[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043922

negative regulation by host of viral transcription

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0045671

negative regulation of osteoclast differentiation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0045672

positive regulation of osteoclast differentiation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P50229

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3044466
PMID:15155903[4]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0048245

eosinophil chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0048246

macrophage chemotaxis

MGI:MGI:5301204
PMID:21784977[5]

IGI: Inferred from Genetic Interaction

UniProtKB:P22893

P

From MGI

GO:0048247

lymphocyte chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0050718

positive regulation of interleukin-1 beta secretion

MGI:MGI:5301204
PMID:21784977[5]

IGI: Inferred from Genetic Interaction

UniProtKB:P22893

P

From MGI

GO:0050729

positive regulation of inflammatory response

MGI:MGI:5301204
PMID:21784977[5]

IGI: Inferred from Genetic Interaction

UniProtKB:P22893

P

From MGI

GO:0050850

positive regulation of calcium-mediated signaling

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0050918

positive chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0051928

positive regulation of calcium ion transport

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0051930

regulation of sensory perception of pain

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0070374

positive regulation of ERK1 and ERK2 cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0070723

response to cholesterol

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0071407

cellular response to organic cyclic compound

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:0071621

granulocyte chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI

GO:2000503

positive regulation of natural killer cell chemotaxis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P10147

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Post, TW et al. (1995) Molecular characterization of two murine eosinophil beta chemokine receptors. J. Immunol. 155 5299-305 PubMed GONUTS page
  2. Nibbs, RJ et al. (1997) Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J. Biol. Chem. 272 12495-504 PubMed GONUTS page
  3. Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Wu, YP & Proia, RL (2004) Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease mice. Proc. Natl. Acad. Sci. U.S.A. 101 8425-30 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Kang, JG et al. (2011) Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. J. Immunol. 187 2696-701 PubMed GONUTS page
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