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MGI:Ccl2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ccl2 ( synonyms: HC11, MCAF, MCP-1, MCP1, monocyte chemoattractant protein-1, monocyte chemotactic protein, Scya2, Sigje, SMC-CF ) | |
| Protein Name(s) | chemokine (C-C motif) ligand 2, | |
| External Links | ||
| MGI | MGI:98259 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000165 |
MAPK cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001525 |
angiogenesis |
MGI:MGI:4943388 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0001664 |
G-protein coupled receptor binding |
MGI:MGI:1099921 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001664 |
G-protein coupled receptor binding |
MGI:MGI:79768 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001938 |
positive regulation of endothelial cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002548 |
monocyte chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0202 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:79768 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:3839525 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006874 |
cellular calcium ion homeostasis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006935 |
chemotaxis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0145 |
P |
From MGI |
||
| GO:0006954 |
inflammatory response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007010 |
cytoskeleton organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008009 |
chemokine activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008201 |
heparin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008360 |
regulation of cell shape |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009408 |
response to heat |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009611 |
response to wounding |
MGI:MGI:3844151 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010574 |
regulation of vascular endothelial growth factor production |
MGI:MGI:3840068 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010759 |
positive regulation of macrophage chemotaxis |
MGI:MGI:3840068 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016525 |
negative regulation of angiogenesis |
MGI:MGI:3840068 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019725 |
cellular homeostasis |
MGI:MGI:4943388 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0030593 |
neutrophil chemotaxis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031727 |
CCR2 chemokine receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031727 |
CCR2 chemokine receptor binding |
MGI:MGI:80507 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0035684 |
helper T cell extravasation |
MGI:MGI:3812298 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043277 |
apoptotic cell clearance |
MGI:MGI:4943793 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043491 |
protein kinase B signaling cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043615 |
astrocyte cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048010 |
vascular endothelial growth factor receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048246 |
macrophage chemotaxis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048246 |
macrophage chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048247 |
lymphocyte chemotaxis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050806 |
positive regulation of synaptic transmission |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050870 |
positive regulation of T cell activation |
MGI:MGI:3699670 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051770 |
positive regulation of nitric-oxide synthase biosynthetic process |
MGI:MGI:4943659 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070098 |
chemokine-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071222 |
cellular response to lipopolysaccharide |
MGI:MGI:3699670 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071346 |
cellular response to interferon-gamma |
MGI:MGI:3699670 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071347 |
cellular response to interleukin-1 |
MGI:MGI:3699670 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071356 |
cellular response to tumor necrosis factor |
MGI:MGI:3699670 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071407 |
cellular response to organic cyclic compound |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090265 |
positive regulation of immune complex clearance by monocytes and macrophages |
MGI:MGI:3840068 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000502 |
negative regulation of natural killer cell chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Tsui P et al. (2007) Generation, characterization and biological activity of CCL2 (MCP-1/JE) and CCL12 (MCP-5) specific antibodies. Hum Antibodies 16: 117-25 PubMed GONUTS page
- ↑ Boring L et al. (1997) Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest 100: 2552-61 PubMed GONUTS page
- ↑ 3.0 3.1 Boring L et al. (1996) Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. J Biol Chem 271: 7551-8 PubMed GONUTS page
- ↑ Deshmukh HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun 77: 1376-82 PubMed GONUTS page
- ↑ Esteban V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS One 4: e5406 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Ambati J et al. (2003) An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med 9: 1390-7 PubMed GONUTS page
- ↑ Kurihara T & Bravo R (1996) Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC. J Biol Chem 271: 11603-7 PubMed GONUTS page
- ↑ Webb A et al. (2008) Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists. J Leukoc Biol 84: 1202-12 PubMed GONUTS page
- ↑ Tanaka T et al. (2010) Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation. Biochem Biophys Res Commun 399: 677-82 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 Lee I et al. (2003) Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. J Immunol 171: 6929-35 PubMed GONUTS page
- ↑ Aoki T et al. (2009) Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation. Stroke 40: 942-51 PubMed GONUTS page
