MGI:Cbs

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001958	endochondral ossification	MGI:MGI:3656462 PMID:15622513^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0001974	blood vessel remodeling	MGI:MGI:3625574 PMID:12433838^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0003824	catalytic activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001926	F	From MGI
	GO:0004122	cystathionine beta-synthase activity	MGI:MGI:1888627 PMID:10953023^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	F	From MGI
	GO:0004122	cystathionine beta-synthase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P32232	F	From MGI
	GO:0004122	cystathionine beta-synthase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	F	From MGI
	GO:0004122	cystathionine beta-synthase activity	MGI:MGI:71081 PMID:7878023^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	F	From MGI
	GO:0004124	cysteine synthase activity	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.5.1.47	F	From MGI
	GO:0005625	soluble fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P32232	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	C	From MGI
	GO:0005730	nucleolus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:B7Z2D6	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0963	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR005857	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	C	From MGI
	GO:0006535	cysteine biosynthetic process from serine	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001216	P	From MGI
	GO:0006563	L-serine metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	P	From MGI
	GO:0006565	L-serine catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	P	From MGI
	GO:0006801	superoxide metabolic process	MGI:MGI:1888627 PMID:10953023^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0008152	metabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001926	P	From MGI
	GO:0008652	cellular amino acid biosynthetic process	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0028	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016829	lyase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0456	F	From MGI
	GO:0019343	cysteine biosynthetic process via cystathionine	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR005857	P	From MGI
	GO:0019344	cysteine biosynthetic process	MGI:MGI:3044255 PMID:15030387^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0019346	transsulfuration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P32232	P	From MGI
	GO:0019448	L-cysteine catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	P	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	F	From MGI
	GO:0020037	heme binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	F	From MGI
	GO:0021587	cerebellum morphogenesis	MGI:MGI:3607901 PMID:16160063^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0030170	pyridoxal phosphate binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	F	From MGI
	GO:0030823	regulation of cGMP metabolic process	MGI:MGI:1888627 PMID:10953023^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0031625	ubiquitin protein ligase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	F	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	F	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P32232	P	From MGI
	GO:0043231	intracellular membrane-bounded organelle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:B7Z2D6	C	From MGI
	GO:0043418	homocysteine catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	P	From MGI
	GO:0043506	regulation of JUN kinase activity	MGI:MGI:3044255 PMID:15030387^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:1888627 PMID:10953023^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:1890086 PMID:10993757^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:3039983 PMID:15131763^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:3510570 PMID:15555590^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:3611588 PMID:15916860^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:3656462 PMID:15622513^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:3656462 PMID:15622513^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:3663564 PMID:16226235^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:3798351 PMID:18541157^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P32232	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	P	From MGI
	GO:0050667	homocysteine metabolic process	MGI:MGI:71081 PMID:7878023^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0050880	regulation of blood vessel size	MGI:MGI:1888627 PMID:10953023^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0051593	response to folic acid	MGI:MGI:1890086 PMID:10993757^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0060135	maternal process involved in female pregnancy	MGI:MGI:3690257 PMID:16984962^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0060351	cartilage development involved in endochondral bone morphogenesis	MGI:MGI:3656462 PMID:15622513^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857139	P	From MGI
	GO:0070814	hydrogen sulfide biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P32232	P	From MGI
	GO:0070814	hydrogen sulfide biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	P	From MGI
	GO:0071456	cellular response to hypoxia	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P32232	P	From MGI
	GO:0072341	modified amino acid binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35520	F	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Robert K et al. (2005) Cystathionine beta synthase deficiency affects mouse endochondral ossification. Anat Rec A Discov Mol Cell Evol Biol 282: 1-7 PubMed GONUTS page
↑ Baumbach GL et al. (2002) Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circ Res 91: 931-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Eberhardt RT et al. (2000) Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest 106: 483-91 PubMed GONUTS page
↑ ^4.0 ^4.1 Watanabe M et al. (1995) Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U S A 92: 1585-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Robert K et al. (2004) The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia. J Neurochem 89: 33-43 PubMed GONUTS page
↑ Enokido Y et al. (2005) Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS. FASEB J 19: 1854-6 PubMed GONUTS page
↑ ^7.0 ^7.1 Lentz SR et al. (2000) Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. Am J Physiol Heart Circ Physiol 279: H970-5 PubMed GONUTS page
↑ Schwahn BC et al. (2004) Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Metabolism 53: 594-9 PubMed GONUTS page
↑ Bar-Or D et al. (2004) Plasma albumin cysteinylation is regulated by cystathionine beta-synthase. Biochem Biophys Res Commun 325: 1449-53 PubMed GONUTS page
↑ Robert K et al. (2005) Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus. Neuroscience 133: 925-35 PubMed GONUTS page
↑ Tan H et al. (2006) Hyperhomocysteinemia inhibits post-injury reendothelialization in mice. Cardiovasc Res 69: 253-62 PubMed GONUTS page
↑ Hamelet J et al. (2008) Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver. Biochim Biophys Acta 1782: 482-8 PubMed GONUTS page
↑ Guzmán MA et al. (2006) Cystathionine beta-synthase is essential for female reproductive function. Hum Mol Genet 15: 3168-76 PubMed GONUTS page

[PMID:15622513-0] 1.0 ^1.1 ^1.2 ^1.3 Robert K et al. (2005) Cystathionine beta synthase deficiency affects mouse endochondral ossification. Anat Rec A Discov Mol Cell Evol Biol 282: 1-7 PubMed GONUTS page

[PMID:12433838-1] Baumbach GL et al. (2002) Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circ Res 91: 931-7 PubMed GONUTS page

[PMID:10953023-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Eberhardt RT et al. (2000) Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest 106: 483-91 PubMed GONUTS page

[PMID:7878023-3] 4.0 ^4.1 Watanabe M et al. (1995) Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U S A 92: 1585-9 PubMed GONUTS page

[PMID:15030387-4] 5.0 ^5.1 Robert K et al. (2004) The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia. J Neurochem 89: 33-43 PubMed GONUTS page

[PMID:16160063-5] Enokido Y et al. (2005) Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS. FASEB J 19: 1854-6 PubMed GONUTS page

[PMID:10993757-6] 7.0 ^7.1 Lentz SR et al. (2000) Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. Am J Physiol Heart Circ Physiol 279: H970-5 PubMed GONUTS page

[PMID:15131763-7] Schwahn BC et al. (2004) Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Metabolism 53: 594-9 PubMed GONUTS page

[PMID:15555590-8] Bar-Or D et al. (2004) Plasma albumin cysteinylation is regulated by cystathionine beta-synthase. Biochem Biophys Res Commun 325: 1449-53 PubMed GONUTS page

[PMID:15916860-9] Robert K et al. (2005) Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus. Neuroscience 133: 925-35 PubMed GONUTS page

[PMID:16226235-10] Tan H et al. (2006) Hyperhomocysteinemia inhibits post-injury reendothelialization in mice. Cardiovasc Res 69: 253-62 PubMed GONUTS page

[PMID:18541157-11] Hamelet J et al. (2008) Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver. Biochim Biophys Acta 1782: 482-8 PubMed GONUTS page

[PMID:16984962-12] Guzmán MA et al. (2006) Cystathionine beta-synthase is essential for female reproductive function. Hum Mol Genet 15: 3168-76 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Cbs ( synonyms: HIP4 )
Protein Name(s)	cystathionine beta-synthase,
External Links
MGI	MGI:88285

MGI:Cbs

Contents

Annotations

Notes

References

b

c

e

e cont.

h

i

l

m

n

p

r

s

t

u

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox