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MGI:Cav3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Cav3 ( synonyms: Cav-3, M-caveolin ) | |
| Protein Name(s) | caveolin 3, | |
| External Links | ||
| MGI | MGI:107570 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
MGI:MGI:1927714 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2682500 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3505818 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3526601 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3622508 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:81176 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:1888583 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:3505818 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0333 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1927714 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2682500 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3526601 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3695802 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:2388238 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:3051094 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:3628972 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:85086 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006469 |
negative regulation of protein kinase activity |
MGI:MGI:2682500 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006641 |
triglyceride metabolic process |
MGI:MGI:3052616 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2684578 |
P |
From MGI |
||
| GO:0006897 |
endocytosis |
MGI:MGI:1339528 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006897 |
endocytosis |
MGI:MGI:2682500 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007009 |
plasma membrane organization |
MGI:MGI:1928619 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2684578 |
P |
From MGI |
||
| GO:0007009 |
plasma membrane organization |
MGI:MGI:2388238 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180558 |
P |
From MGI |
||
| GO:0007009 |
plasma membrane organization |
MGI:MGI:2682500 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007204 |
elevation of cytosolic calcium ion concentration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008104 |
protein localization |
MGI:MGI:2135840 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180558 |
P |
From MGI |
||
| GO:0008104 |
protein localization |
MGI:MGI:2388238 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180558 |
P |
From MGI |
||
| GO:0008104 |
protein localization |
MGI:MGI:2682500 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008104 |
protein localization |
MGI:MGI:3526601 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107231 |
P |
From MGI |
||
| GO:0008104 |
protein localization |
MGI:MGI:3612003 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010614 |
negative regulation of cardiac muscle hypertrophy |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014819 |
regulation of skeletal muscle contraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016010 |
dystrophin-associated glycoprotein complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0017080 |
sodium channel regulator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019899 |
enzyme binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030315 |
T-tubule |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030315 |
T-tubule |
MGI:MGI:3612003 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030315 |
T-tubule |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030315 |
T-tubule |
MGI:MGI:85086 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031116 |
positive regulation of microtubule polymerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031579 |
membrane raft organization |
MGI:MGI:2135840 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180558 |
P |
From MGI |
||
| GO:0031579 |
membrane raft organization |
MGI:MGI:2682500 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0031594 |
neuromuscular junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032947 |
protein complex scaffold |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:1928619 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:2388238 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:3612003 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:3622508 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:81176 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:85086 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042391 |
regulation of membrane potential |
MGI:MGI:3526601 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96662 |
P |
From MGI |
||
| GO:0042593 |
glucose homeostasis |
MGI:MGI:3052616 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2684578 |
P |
From MGI |
||
| GO:0042598 |
vesicular fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042632 |
cholesterol homeostasis |
MGI:MGI:3052616 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2684578 |
P |
From MGI |
||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043407 |
negative regulation of MAP kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043409 |
negative regulation of MAPK cascade |
MGI:MGI:2388238 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180558 |
P |
From MGI |
||
| GO:0045121 |
membrane raft |
MGI:MGI:2135840 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045792 |
negative regulation of cell size |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046716 |
muscle cell homeostasis |
MGI:MGI:1928619 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2684578 |
P |
From MGI |
||
| GO:0046716 |
muscle cell homeostasis |
MGI:MGI:2388238 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180558 |
P |
From MGI |
||
| GO:0046716 |
muscle cell homeostasis |
MGI:MGI:2682500 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050998 |
nitric-oxide synthase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051001 |
negative regulation of nitric-oxide synthase activity |
MGI:MGI:1930012 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180562 |
P |
From MGI |
||
| GO:0051925 |
regulation of calcium ion transport via voltage-gated calcium channel activity |
MGI:MGI:3628972 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0055117 |
regulation of cardiac muscle contraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060299 |
negative regulation of sarcomere organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060307 |
regulation of ventricular cardiomyocyte membrane repolarization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0072659 |
protein localization in plasma membrane |
MGI:MGI:3622508 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
|
colocalizes_with |
GO:0005901 |
caveola |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
||
|
colocalizes_with |
GO:0030018 |
Z disc |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
||
|
colocalizes_with |
GO:0042383 |
sarcolemma |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
||
|
colocalizes_with |
GO:0044424 |
intracellular part |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Sotgia F et al. (2000) Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members. J Biol Chem 275: 38048-58 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Smythe GM et al. (2003) A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes. J Cell Sci 116: 4739-49 PubMed GONUTS page
- ↑ 3.0 3.1 Minamisawa S et al. (2004) Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun 325: 852-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Folco EJ et al. (2004) Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5. Am J Physiol Heart Circ Physiol 287: H681-90 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Fecchi K et al. (2006) Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells. FASEB J 20: 705-7 PubMed GONUTS page
- ↑ 6.0 6.1 Song KS et al. (1996) Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J Biol Chem 271: 15160-5 PubMed GONUTS page
- ↑ Biederer CH et al. (2000) The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic development. J Biol Chem 275: 26245-51 PubMed GONUTS page
- ↑ Schubert W et al. (2007) Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation. Am J Pathol 170: 316-33 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Woodman SE et al. (2002) Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. J Biol Chem 277: 38988-97 PubMed GONUTS page
- ↑ Trinidad JC & Cohen JB (2004) Neuregulin inhibits acetylcholine receptor aggregation in myotubes. J Biol Chem 279: 31622-8 PubMed GONUTS page
- ↑ 11.0 11.1 Balijepalli RC et al. (2006) Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation. Proc Natl Acad Sci U S A 103: 7500-5 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Parton RG et al. (1997) Caveolin-3 associates with developing T-tubules during muscle differentiation. J Cell Biol 136: 137-54 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Oshikawa J et al. (2004) Insulin resistance in skeletal muscles of caveolin-3-null mice. Proc Natl Acad Sci U S A 101: 12670-5 PubMed GONUTS page
- ↑ Das K et al. (1999) The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo. J Biol Chem 274: 18721-8 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Hagiwara Y et al. (2000) Caveolin-3 deficiency causes muscle degeneration in mice. Hum Mol Genet 9: 3047-54 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Galbiati F et al. (2001) Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities. J Biol Chem 276: 21425-33 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Hernández-Deviez DJ et al. (2006) Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3. Hum Mol Genet 15: 129-42 PubMed GONUTS page
- ↑ Sunada Y et al. (2001) Transgenic mice expressing mutant caveolin-3 show severe myopathy associated with increased nNOS activity. Hum Mol Genet 10: 173-8 PubMed GONUTS page
