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MGI:Casp1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Casp1 ( synonyms: Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme ) | |
| Protein Name(s) | caspase 1, | |
| External Links | ||
| MGI | MGI:96544 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001666 |
response to hypoxia |
MGI:MGI:3029677 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1927822 |
P |
From MGI |
||
| GO:0001666 |
response to hypoxia |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001774 |
microglial cell activation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR011600 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3687416 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3687689 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:3046391 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3046391 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0006915 |
apoptotic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:3029677 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1927822 |
P |
From MGI |
||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:3046391 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007520 |
myoblast fusion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007613 |
memory |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008152 |
metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR011600 |
P |
From MGI |
||
| GO:0008219 |
cell death |
MGI:MGI:3583691 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008233 |
peptidase activity |
MGI:MGI:3796019 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008234 |
cysteine-type peptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0788 |
F |
From MGI |
||
| GO:0008234 |
cysteine-type peptidase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0014070 |
response to organic cyclic compound |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016485 |
protein processing |
MGI:MGI:1929334 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016485 |
protein processing |
MGI:MGI:3029677 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1927822 |
P |
From MGI |
||
| GO:0016485 |
protein processing |
MGI:MGI:3046391 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016485 |
protein processing |
MGI:MGI:3713415 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0032496 |
response to lipopolysaccharide |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032611 |
interleukin-1 beta production |
MGI:MGI:3836373 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96543 |
P |
From MGI |
||
| GO:0033198 |
response to ATP |
MGI:MGI:3796019 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042221 |
response to chemical stimulus |
MGI:MGI:3713415 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0043005 |
neuron projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0046010 |
positive regulation of circadian sleep/wake cycle, non-REM sleep |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050715 |
positive regulation of cytokine secretion |
MGI:MGI:3796019 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050715 |
positive regulation of cytokine secretion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050717 |
positive regulation of interleukin-1 alpha secretion |
MGI:MGI:3796019 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050718 |
positive regulation of interleukin-1 beta secretion |
MGI:MGI:3796019 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050718 |
positive regulation of interleukin-1 beta secretion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071310 |
cellular response to organic substance |
MGI:MGI:3836373 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0097110 |
scaffold protein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Zhang WH et al. (2003) Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Proc Natl Acad Sci U S A 100: 16012-7 PubMed GONUTS page
- ↑ Chen Y et al. (1996) A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J 15: 3853-60 PubMed GONUTS page
- ↑ Hersh D et al. (1999) The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc Natl Acad Sci U S A 96: 2396-401 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Mariathasan S et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430: 213-8 PubMed GONUTS page
- ↑ Boyden ED & Dietrich WF (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38: 240-4 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Pelegrin P et al. (2008) P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol 180: 7147-57 PubMed GONUTS page
- ↑ Solle M et al. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem 276: 125-32 PubMed GONUTS page
- ↑ 8.0 8.1 Verhoef PA et al. (2005) Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J Immunol 175: 7623-34 PubMed GONUTS page
- ↑ 9.0 9.1 Bürckstümmer T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 10: 266-72 PubMed GONUTS page
