MGI:Calca

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001935	endothelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0001944	vasculature development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	MGI:MGI:1352568 PMID:10642343^[1]	ISA: Inferred from Sequence Alignment	UniProtKB:P06881-1	P	From MGI
	GO:0001984	vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure	MGI:MGI:2445452 PMID:11717154^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445489	P	From MGI
	GO:0002027	regulation of heart rate	MGI:MGI:2445452 PMID:11717154^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445489	P	From MGI
	GO:0002031	G-protein coupled receptor internalization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0002548	monocyte chemotaxis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01258	P	From MGI
	GO:0005102	receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	F	From MGI
	GO:0005102	receptor binding	MGI:MGI:66405 PMID:8278635^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005102	receptor binding	MGI:MGI:67883 PMID:7955356^[4]	TAS: Traceable Author Statement		F	From MGI
	GO:0005102	receptor binding	MGI:MGI:69771 PMID:7698182^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005179	hormone activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0372	F	From MGI
	GO:0005179	hormone activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR018360 InterPro:IPR001693 InterPro:IPR021117 InterPro:IPR021116 InterPro:IPR021118 InterPro:IPR015476	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:67883 PMID:7955356^[4]	TAS: Traceable Author Statement		C	From MGI
	GO:0005576	extracellular region	MGI:MGI:81458 PMID:8735980^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1929585 PMID:11208722^[7]	ISO: Inferred from Sequence Orthology	UniProtKB:P01257	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3028786 PMID:14765981^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01258	C	From MGI
	GO:0005622	intracellular	MGI:MGI:2671689 PMID:12888222^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005622	intracellular	MGI:MGI:67883 PMID:7955356^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005622	intracellular	MGI:MGI:77881 PMID:8582325^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:1926944	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01256	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:2150459 PMID:11551509^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:3028786 PMID:14765981^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:894060 PMID:9271704^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0006874	cellular calcium ion homeostasis	MGI:MGI:2447255 PMID:12488435^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:97799	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:69771 PMID:7698182^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007159	leukocyte cell-cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:77881 PMID:8582325^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:1926944	P	From MGI
	GO:0007190	activation of adenylate cyclase activity	MGI:MGI:2656992 PMID:12704735^[14]	ISA: Inferred from Sequence Alignment	UniProtKB:P01263	P	From MGI
	GO:0007190	activation of adenylate cyclase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0007190	activation of adenylate cyclase activity	MGI:MGI:77881 PMID:8582325^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007204	elevation of cytosolic calcium ion concentration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01258	P	From MGI
	GO:0007218	neuropeptide signaling pathway	MGI:MGI:69771 PMID:7698182^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007566	embryo implantation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01258	P	From MGI
	GO:0007631	feeding behavior	MGI:MGI:81458 PMID:8735980^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008016	regulation of heart contraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01256	P	From MGI
	GO:0009408	response to heat	MGI:MGI:3603999 PMID:16118273^[15]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0009408	response to heat	MGI:MGI:3608457 PMID:11166483^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3527257	P	From MGI
	GO:0010523	negative regulation of calcium ion transport into cytosol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0030279	negative regulation of ossification	MGI:MGI:2447255 PMID:12488435^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3527257	P	From MGI
	GO:0030279	negative regulation of ossification	MGI:MGI:3653805 PMID:15537449^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3527257	P	From MGI
	GO:0030424	axon	MGI:MGI:1098517 PMID:1317267^[18]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030424	axon	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01256	C	From MGI
	GO:0030424	axon	MGI:MGI:62241 PMID:8261138^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030424	axon	MGI:MGI:67873 PMID:7521790^[20]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030424	axon	MGI:MGI:77881 PMID:8582325^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030819	positive regulation of cAMP biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0031623	receptor internalization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0031645	negative regulation of neurological system process	MGI:MGI:2445452 PMID:11717154^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445489	P	From MGI
	GO:0031716	calcitonin receptor binding	MGI:MGI:1098356 PMID:9322931^[21]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0031716	calcitonin receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01256	F	From MGI
	GO:0031716	calcitonin receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01258	F	From MGI
	GO:0032147	activation of protein kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01258	P	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	F	From MGI
	GO:0032730	positive regulation of interleukin-1 alpha production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0032757	positive regulation of interleukin-8 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0042311	vasodilation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01256	P	From MGI
	GO:0043005	neuron projection	MGI:MGI:3653818 PMID:11466438^[22]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043025	neuronal cell body	MGI:MGI:1316900 PMID:9838101^[23]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043195	terminal button	MGI:MGI:1306999 PMID:9853118^[24]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043195	terminal button	MGI:MGI:1335275 PMID:10208559^[25]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043195	terminal button	MGI:MGI:1345568 PMID:10532808^[26]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043195	terminal button	MGI:MGI:52986 PMID:8453761^[27]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043542	endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0045651	positive regulation of macrophage differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0045671	negative regulation of osteoclast differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0045762	positive regulation of adenylate cyclase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01258	P	From MGI
	GO:0045776	negative regulation of blood pressure	MGI:MGI:1352568 PMID:10642343^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3527257	P	From MGI
	GO:0045776	negative regulation of blood pressure	MGI:MGI:1352568 PMID:10642343^[1]	ISA: Inferred from Sequence Alignment	UniProtKB:P06881-1	P	From MGI
	GO:0045776	negative regulation of blood pressure	MGI:MGI:2445452 PMID:11717154^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445489	P	From MGI
	GO:0045776	negative regulation of blood pressure	MGI:MGI:3639075 PMID:15583078^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3527257	P	From MGI
	GO:0045776	negative regulation of blood pressure	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01256	P	From MGI
	GO:0045778	positive regulation of ossification	MGI:MGI:3653805 PMID:15537449^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2148538	P	From MGI
	GO:0045779	negative regulation of bone resorption	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01258	P	From MGI
	GO:0045785	positive regulation of cell adhesion	MGI:MGI:78878	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01258	P	From MGI
	GO:0045909	positive regulation of vasodilation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0045986	negative regulation of smooth muscle contraction	MGI:MGI:1098356 PMID:9322931^[21]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045986	negative regulation of smooth muscle contraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01256	P	From MGI
	GO:0048240	sperm capacitation	MGI:MGI:2656992 PMID:12704735^[14]	ISA: Inferred from Sequence Alignment	UniProtKB:P01263	P	From MGI
	GO:0048265	response to pain	MGI:MGI:1335275 PMID:10208559^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2148771	P	From MGI
	GO:0048265	response to pain	MGI:MGI:1933070 PMID:11276224^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2148771	P	From MGI
	GO:0050727	regulation of inflammatory response	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P01256	P	From MGI
	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	MGI:MGI:3603999 PMID:16118273^[15]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051480	cytosolic calcium ion homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06881	P	From MGI
	GO:0051482	elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01258	P	From MGI
NOT	GO:0007528	neuromuscular junction development	MGI:MGI:1345568 PMID:10532808^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2148538	P	From MGI
NOT	GO:0008217	regulation of blood pressure	MGI:MGI:1345568 PMID:10532808^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2148538	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Gangula PR et al. (2000) Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice. Hypertension 35: 470-5 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Oh-hashi Y et al. (2001) Elevated sympathetic nervous activity in mice deficient in alphaCGRP. Circ Res 89: 983-90 PubMed GONUTS page
↑ Mullins MW et al. (1993) Characterization of a calcitonin gene-related peptide (CGRP) receptor on mouse bone marrow cells. Regul Pept 49: 65-72 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Jakab G et al. (1994) The calcitonin gene-related peptide (CGRP) phenotype is expressed early and up-regulated by resiniferatoxin (RTX) in mouse sensory neurons. Brain Res Dev Brain Res 80: 290-4 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Ahluwalia A & Perretti M (1994) Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse. Eur J Pharmacol 264: 407-15 PubMed GONUTS page
↑ ^6.0 ^6.1 Morley JE et al. (1996) Peripherally administered calcitonin gene-related peptide decreases food intake in mice. Peptides 17: 511-6 PubMed GONUTS page
↑ Boku K et al. (2001) Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology 120: 134-43 PubMed GONUTS page
↑ ^8.0 ^8.1 Ismail PM et al. (2004) Progesterone induction of calcitonin expression in the murine mammary gland. J Endocrinol 180: 287-95 PubMed GONUTS page
↑ Funakoshi K et al. (2003) Prenatal development of peptidergic primary afferent projections to mouse lumbosacral autonomic preganglionic cell columns. Brain Res Dev Brain Res 144: 107-19 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Bidegain M et al. (1995) Calcitonin gene-related peptide (CGRP) in the developing mouse limb. Endocr Res 21: 743-55 PubMed GONUTS page
↑ Dong X et al. (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106: 619-32 PubMed GONUTS page
↑ Verástegui C et al. (1997) Calcitonin gene-related peptide immunoreactivity in adult mouse lung. Eur J Histochem 41: 119-26 PubMed GONUTS page
↑ ^13.0 ^13.1 Hoff AO et al. (2002) Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. J Clin Invest 110: 1849-57 PubMed GONUTS page
↑ ^14.0 ^14.1 Adeoya-Osiguwa SA & Fraser LR (2003) Calcitonin acts as a first messenger to regulate adenylyl cyclase/cAMP and mammalian sperm function. Mol Reprod Dev 65: 228-36 PubMed GONUTS page
↑ ^15.0 ^15.1 Mogil JS et al. (2005) Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc Natl Acad Sci U S A 102: 12938-43 PubMed GONUTS page
↑ Zhang L et al. (2001) Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity. Pain 89: 265-73 PubMed GONUTS page
↑ ^17.0 ^17.1 Schinke T et al. (2004) Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide. J Bone Miner Res 19: 2049-56 PubMed GONUTS page
↑ Lee KF et al. (1992) Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69: 737-49 PubMed GONUTS page
↑ Denis-Donini S et al. (1993) Developmentally regulated expression of CGRP in the mouse olfactory pathway. Eur J Neurosci 5: 648-56 PubMed GONUTS page
↑ Kimura M et al. (1994) Nerve fibers immunoreactive for substance P and calcitonin gene-related peptide in the cervical spinal ventral roots of the mouse. Cell Tissue Res 277: 273-8 PubMed GONUTS page
↑ ^21.0 ^21.1 Naghashpour M et al. (1997) Inhibitory effect of calcitonin gene-related peptide on myometrial contractility is diminished at parturition. Endocrinology 138: 4207-14 PubMed GONUTS page
↑ Vlaskovska M et al. (2001) P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci 21: 5670-7 PubMed GONUTS page
↑ Gebre-Medhin S et al. (1998) Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice. Brain Res Mol Brain Res 63: 180-3 PubMed GONUTS page
↑ Sang Q & Young HM (1998) The origin and development of the vagal and spinal innervation of the external muscle of the mouse esophagus. Brain Res 809: 253-68 PubMed GONUTS page
↑ ^25.0 ^25.1 Salmon AM et al. (1999) Modulation of morphine analgesia in alphaCGRP mutant mice. Neuroreport 10: 849-54 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Lu JT et al. (1999) Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol Cell Neurosci 14: 99-120 PubMed GONUTS page
↑ Yamano M & Tohyama M (1993) The innervation of calcitonin gene-related peptide to the Purkinje cells and granule cells in the developing mouse cerebellum. Brain Res Dev Brain Res 72: 107-17 PubMed GONUTS page
↑ Supowit SC et al. (2005) Calcitonin gene-related peptide protects against hypertension-induced heart and kidney damage. Hypertension 45: 109-14 PubMed GONUTS page
↑ Salmon AM et al. (2001) Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice. Nat Neurosci 4: 357-8 PubMed GONUTS page

[PMID:10642343-0] 1.0 ^1.1 ^1.2 Gangula PR et al. (2000) Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice. Hypertension 35: 470-5 PubMed GONUTS page

[PMID:11717154-1] 2.0 ^2.1 ^2.2 ^2.3 Oh-hashi Y et al. (2001) Elevated sympathetic nervous activity in mice deficient in alphaCGRP. Circ Res 89: 983-90 PubMed GONUTS page

[PMID:8278635-2] Mullins MW et al. (1993) Characterization of a calcitonin gene-related peptide (CGRP) receptor on mouse bone marrow cells. Regul Pept 49: 65-72 PubMed GONUTS page

[PMID:7955356-3] 4.0 ^4.1 ^4.2 Jakab G et al. (1994) The calcitonin gene-related peptide (CGRP) phenotype is expressed early and up-regulated by resiniferatoxin (RTX) in mouse sensory neurons. Brain Res Dev Brain Res 80: 290-4 PubMed GONUTS page

[PMID:7698182-4] 5.0 ^5.1 ^5.2 Ahluwalia A & Perretti M (1994) Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse. Eur J Pharmacol 264: 407-15 PubMed GONUTS page

[PMID:8735980-5] 6.0 ^6.1 Morley JE et al. (1996) Peripherally administered calcitonin gene-related peptide decreases food intake in mice. Peptides 17: 511-6 PubMed GONUTS page

[PMID:11208722-6] Boku K et al. (2001) Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology 120: 134-43 PubMed GONUTS page

[PMID:14765981-7] 8.0 ^8.1 Ismail PM et al. (2004) Progesterone induction of calcitonin expression in the murine mammary gland. J Endocrinol 180: 287-95 PubMed GONUTS page

[PMID:12888222-8] Funakoshi K et al. (2003) Prenatal development of peptidergic primary afferent projections to mouse lumbosacral autonomic preganglionic cell columns. Brain Res Dev Brain Res 144: 107-19 PubMed GONUTS page

[PMID:8582325-9] 10.0 ^10.1 ^10.2 ^10.3 Bidegain M et al. (1995) Calcitonin gene-related peptide (CGRP) in the developing mouse limb. Endocr Res 21: 743-55 PubMed GONUTS page

[PMID:11551509-10] Dong X et al. (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106: 619-32 PubMed GONUTS page

[PMID:9271704-11] Verástegui C et al. (1997) Calcitonin gene-related peptide immunoreactivity in adult mouse lung. Eur J Histochem 41: 119-26 PubMed GONUTS page

[PMID:12488435-12] 13.0 ^13.1 Hoff AO et al. (2002) Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. J Clin Invest 110: 1849-57 PubMed GONUTS page

[PMID:12704735-13] 14.0 ^14.1 Adeoya-Osiguwa SA & Fraser LR (2003) Calcitonin acts as a first messenger to regulate adenylyl cyclase/cAMP and mammalian sperm function. Mol Reprod Dev 65: 228-36 PubMed GONUTS page

[PMID:16118273-14] 15.0 ^15.1 Mogil JS et al. (2005) Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc Natl Acad Sci U S A 102: 12938-43 PubMed GONUTS page

[PMID:11166483-15] Zhang L et al. (2001) Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity. Pain 89: 265-73 PubMed GONUTS page

[PMID:15537449-16] 17.0 ^17.1 Schinke T et al. (2004) Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide. J Bone Miner Res 19: 2049-56 PubMed GONUTS page

[PMID:1317267-17] Lee KF et al. (1992) Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69: 737-49 PubMed GONUTS page

[PMID:8261138-18] Denis-Donini S et al. (1993) Developmentally regulated expression of CGRP in the mouse olfactory pathway. Eur J Neurosci 5: 648-56 PubMed GONUTS page

[PMID:7521790-19] Kimura M et al. (1994) Nerve fibers immunoreactive for substance P and calcitonin gene-related peptide in the cervical spinal ventral roots of the mouse. Cell Tissue Res 277: 273-8 PubMed GONUTS page

[PMID:9322931-20] 21.0 ^21.1 Naghashpour M et al. (1997) Inhibitory effect of calcitonin gene-related peptide on myometrial contractility is diminished at parturition. Endocrinology 138: 4207-14 PubMed GONUTS page

[PMID:11466438-21] Vlaskovska M et al. (2001) P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci 21: 5670-7 PubMed GONUTS page

[PMID:9838101-22] Gebre-Medhin S et al. (1998) Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice. Brain Res Mol Brain Res 63: 180-3 PubMed GONUTS page

[PMID:9853118-23] Sang Q & Young HM (1998) The origin and development of the vagal and spinal innervation of the external muscle of the mouse esophagus. Brain Res 809: 253-68 PubMed GONUTS page

[PMID:10208559-24] 25.0 ^25.1 Salmon AM et al. (1999) Modulation of morphine analgesia in alphaCGRP mutant mice. Neuroreport 10: 849-54 PubMed GONUTS page

[PMID:10532808-25] 26.0 ^26.1 ^26.2 Lu JT et al. (1999) Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol Cell Neurosci 14: 99-120 PubMed GONUTS page

[PMID:8453761-26] Yamano M & Tohyama M (1993) The innervation of calcitonin gene-related peptide to the Purkinje cells and granule cells in the developing mouse cerebellum. Brain Res Dev Brain Res 72: 107-17 PubMed GONUTS page

[PMID:15583078-27] Supowit SC et al. (2005) Calcitonin gene-related peptide protects against hypertension-induced heart and kidney damage. Hypertension 45: 109-14 PubMed GONUTS page

[PMID:11276224-28] Salmon AM et al. (2001) Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice. Nat Neurosci 4: 357-8 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Calca ( synonyms: alpha CGRP, CA, Calc, Cgrp, CT, Ctn )
Protein Name(s)	calcitonin/calcitonin-related polypeptide, alpha,
External Links
MGI	MGI:2151253

MGI:Calca

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