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MGI:C3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | C3 ( synonyms: acylation stimulating protein, complement factor 3, Plp ) | |
| Protein Name(s) | complement component 3, | |
| External Links | ||
| MGI | MGI:88227 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001798 |
positive regulation of type IIa hypersensitivity |
MGI:MGI:2177393 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861799 |
P |
From MGI |
||
| GO:0001970 |
positive regulation of activation of membrane attack complex |
MGI:MGI:4430818 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0004866 |
endopeptidase inhibitor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2154602 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3613281 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0395 |
P |
From MGI |
||
| GO:0006954 |
inflammatory response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006956 |
complement activation |
MGI:MGI:3833206 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006956 |
complement activation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006957 |
complement activation, alternative pathway |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0179 |
P |
From MGI |
||
| GO:0006958 |
complement activation, classical pathway |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0180 |
P |
From MGI |
||
| GO:0007596 |
blood coagulation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008289 |
lipid binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0010575 |
positive regulation vascular endothelial growth factor production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010951 |
negative regulation of endopeptidase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0399 |
P |
From MGI |
||
| GO:0045766 |
positive regulation of angiogenesis |
MGI:MGI:3617287 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045766 |
positive regulation of angiogenesis |
MGI:MGI:4430818 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048037 |
cofactor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048639 |
positive regulation of developmental growth |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050766 |
positive regulation of phagocytosis |
MGI:MGI:2177393 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861799 |
P |
From MGI |
||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Azeredo da Silveira S et al. (2002) Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med 195: 665-72 PubMed GONUTS page
- ↑ 2.0 2.1 Bora PS et al. (2005) Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization. J Immunol 174: 491-7 PubMed GONUTS page
- ↑ Boackle SA et al. (2001) Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein. Immunity 15: 775-85 PubMed GONUTS page
- ↑ Cheng ZZ et al. (2006) Comparison of surface recognition and C3b binding properties of mouse and human complement factor H. Mol Immunol 43: 972-9 PubMed GONUTS page
- ↑ Ruseva MM et al. (2009) Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury. Mol Immunol 46: 803-11 PubMed GONUTS page
- ↑ Nozaki M et al. (2006) Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A 103: 2328-33 PubMed GONUTS page
