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MGI:Bmpr2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Bmpr2 ( synonyms: BMP-2, BMPR-II, BMPRII ) | |
| Protein Name(s) | bone morphogenic protein receptor, type II (serine/threonine kinase), | |
| External Links | ||
| MGI | MGI:1095407 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001707 |
mesoderm formation |
MGI:MGI:1855789 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158503 |
P |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:3718174 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001938 |
positive regulation of endothelial cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001946 |
lymphangiogenesis |
MGI:MGI:4436974 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001974 |
blood vessel remodeling |
MGI:MGI:4436974 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003085 |
negative regulation of systemic arterial blood pressure |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0723 |
F |
From MGI |
||
| GO:0004675 |
transmembrane receptor protein serine/threonine kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_536332 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005024 |
transforming growth factor beta-activated receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_536332 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_536332 |
C |
From MGI |
||
| GO:0006366 |
transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_536332 |
P |
From MGI |
||
| GO:0007178 |
transmembrane receptor protein serine/threonine kinase signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009925 |
basal plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_536332 |
C |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:1855789 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158503 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:3525050 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:87912 |
P |
From MGI |
||
| GO:0009986 |
cell surface |
MGI:MGI:2181740 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0010595 |
positive regulation of endothelial cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010634 |
positive regulation of epithelial cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014916 |
regulation of lung blood pressure |
MGI:MGI:3799581 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0014916 |
regulation of lung blood pressure |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016324 |
apical plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_536332 |
C |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0019838 |
growth factor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_536332 |
F |
From MGI |
||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_536332 |
C |
From MGI |
||
| GO:0030501 |
positive regulation of bone mineralization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3718174 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3718174 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030513 |
positive regulation of BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_536332 |
C |
From MGI |
||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045906 |
negative regulation of vasoconstriction |
MGI:MGI:3799581 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048010 |
vascular endothelial growth factor receptor signaling pathway |
MGI:MGI:3799581 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048286 |
lung alveolus development |
MGI:MGI:3799581 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060836 |
lymphatic endothelial cell differentiation |
MGI:MGI:4436974 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060840 |
artery development |
MGI:MGI:4436974 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060841 |
venous blood vessel development |
MGI:MGI:4436974 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0061298 |
retina vasculature development in camera-type eye |
MGI:MGI:4436974 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000279 |
negative regulation of DNA biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Beppu H et al. (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol 221: 249-58 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Xia Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem 282: 18129-40 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Niessen K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115: 1654-61 PubMed GONUTS page
- ↑ Park S et al. (2004) B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol Cell Biol 24: 10256-62 PubMed GONUTS page
- ↑ Faber SC et al. (2002) Bmp signaling is required for development of primary lens fiber cells. Development 129: 3727-37 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Song Y et al. (2008) Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice. Am J Physiol Heart Circ Physiol 295: H677-90 PubMed GONUTS page
