![]()
GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Bmp7
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Bmp7 ( synonyms: OP1, osteogenic protein 1 ) | |
| Protein Name(s) | bone morphogenetic protein 7, | |
| External Links | ||
| MGI | MGI:103302 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001503 |
ossification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0892 |
P |
From MGI |
||
| GO:0001654 |
eye development |
MGI:MGI:3610441 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001657 |
ureteric bud development |
MGI:MGI:1289719 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001707 |
mesoderm formation |
MGI:MGI:3578079 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2137520 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:3610441 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136986 |
P |
From MGI |
||
| GO:0005125 |
cytokine activity |
MGI:MGI:77579 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2662055 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2681048 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2683044 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3575605 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3578079 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:2662055 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007389 |
pattern specification process |
MGI:MGI:77579 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0007411 |
axon guidance |
MGI:MGI:2662055 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007435 |
salivary gland morphogenesis |
MGI:MGI:2158598 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0008083 |
growth factor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0339 |
F |
From MGI |
||
| GO:0008083 |
growth factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008201 |
heparin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3701027 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0009880 |
embryonic pattern specification |
MGI:MGI:1332362 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:77579 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010942 |
positive regulation of cell death |
MGI:MGI:3623046 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:1270933 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88180 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:1270933 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1934010 |
P |
From MGI |
||
| GO:0030501 |
positive regulation of bone mineralization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:2681048 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030855 |
epithelial cell differentiation |
MGI:MGI:3765253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136986 |
P |
From MGI |
||
| GO:0031012 |
extracellular matrix |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031988 |
membrane-bounded vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0034116 |
positive regulation of heterotypic cell-cell adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034504 |
protein localization to nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035239 |
tube morphogenesis |
MGI:MGI:3575981 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0040007 |
growth |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0042325 |
regulation of phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042326 |
negative regulation of phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:3513220 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:3701027 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0043401 |
steroid hormone mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043407 |
negative regulation of MAP kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045597 |
positive regulation of cell differentiation |
MGI:MGI:3513220 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:3611623 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:3611623 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:1307014 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045746 |
negative regulation of Notch signaling pathway |
MGI:MGI:3612905 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1099809 |
P |
From MGI |
||
| GO:0045786 |
negative regulation of cell cycle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045839 |
negative regulation of mitosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3654744 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1919200 |
P |
From MGI |
||
| GO:0048468 |
cell development |
MGI:MGI:3575981 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048593 |
camera-type eye morphogenesis |
MGI:MGI:3610441 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136986 |
P |
From MGI |
||
| GO:0048593 |
camera-type eye morphogenesis |
MGI:MGI:3701027 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0048596 |
embryonic camera-type eye morphogenesis |
MGI:MGI:1332362 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0048646 |
anatomical structure formation involved in morphogenesis |
MGI:MGI:1332362 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0048646 |
anatomical structure formation involved in morphogenesis |
MGI:MGI:3701027 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0048646 |
anatomical structure formation involved in morphogenesis |
MGI:MGI:3765253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136986 |
P |
From MGI |
||
| GO:0048754 |
branching morphogenesis of a tube |
MGI:MGI:3575981 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048762 |
mesenchymal cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048812 |
neuron projection morphogenesis |
MGI:MGI:3611623 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048812 |
neuron projection morphogenesis |
MGI:MGI:3611623 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050768 |
negative regulation of neurogenesis |
MGI:MGI:3722226 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051216 |
cartilage development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0891 |
P |
From MGI |
||
| GO:0060272 |
embryonic skeletal joint morphogenesis |
MGI:MGI:1270933 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88180 |
P |
From MGI |
||
| GO:0060272 |
embryonic skeletal joint morphogenesis |
MGI:MGI:1270933 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1934010 |
P |
From MGI |
||
| GO:0060389 |
pathway-restricted SMAD protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060395 |
SMAD protein signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060445 |
branching involved in salivary gland morphogenesis |
MGI:MGI:2158598 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0060485 |
mesenchyme development |
MGI:MGI:1289719 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060548 |
negative regulation of cell death |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060686 |
negative regulation of prostatic bud formation |
MGI:MGI:3612905 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060687 |
regulation of branching involved in prostate gland morphogenesis |
MGI:MGI:3612905 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136986 |
P |
From MGI |
||
| GO:0060687 |
regulation of branching involved in prostate gland morphogenesis |
MGI:MGI:3612905 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136986 |
P |
From MGI |
||
| GO:0070487 |
monocyte aggregation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070700 |
BMP receptor binding |
MGI:MGI:70105 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0072040 |
negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis |
MGI:MGI:86404 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857654 |
P |
From MGI |
||
| GO:0072125 |
negative regulation of glomerular mesangial cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0072133 |
metanephric mesenchyme morphogenesis |
MGI:MGI:3623046 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0072134 |
nephrogenic mesenchyme morphogenesis |
MGI:MGI:3623046 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0072136 |
metanephric mesenchymal cell proliferation involved in metanephros development |
MGI:MGI:3623046 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:1900106 |
positive regulation of hyaluranon cable assembly |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Oxburgh L et al. (2005) BMP4 substitutes for loss of BMP7 during kidney development. Dev Biol 286: 637-46 PubMed GONUTS page
- ↑ 2.0 2.1 Godin RE et al. (1998) Regulation of BMP7 expression during kidney development. Development 125: 3473-82 PubMed GONUTS page
- ↑ 3.0 3.1 Zakin L et al. (2005) Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development 132: 2489-99 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Dudley AT et al. (1995) A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9: 2795-807 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Butler SJ & Dodd J (2003) A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons. Neuron 38: 389-401 PubMed GONUTS page
- ↑ 6.0 6.1 Laurikkala J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol 264: 91-105 PubMed GONUTS page
- ↑ Nakayama N et al. (2004) A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Development 131: 229-40 PubMed GONUTS page
- ↑ Lin J et al. (2005) Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med 11: 387-93 PubMed GONUTS page
- ↑ 9.0 9.1 Jaskoll T et al. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs 170: 83-98 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Morcillo J et al. (2006) Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH. Development 133: 3179-90 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Wawersik S et al. (1999) BMP7 acts in murine lens placode development. Dev Biol 207: 176-88 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 Oxburgh L et al. (2004) TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131: 4593-605 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Katagiri T et al. (1998) Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. Dev Genet 22: 340-8 PubMed GONUTS page
- ↑ 14.0 14.1 Suzuki K et al. (2008) Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4. Eur J Hum Genet 16: 36-44 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Leung-Hagesteijn C et al. (2005) Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol Cell Biol 25: 3648-57 PubMed GONUTS page
- ↑ 16.0 16.1 Wang XP et al. (2004) Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev Cell 7: 719-30 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 Krizhanovsky V & Ben-Arie N (2006) A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech Dev 123: 67-75 PubMed GONUTS page
- ↑ Li W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J Neurosci 18: 8853-62 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 19.3 Grishina IB et al. (2005) BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev Biol 288: 334-47 PubMed GONUTS page
- ↑ Suzuki A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A 103: 10294-9 PubMed GONUTS page
- ↑ Di-Gregorio A et al. (2007) BMP signalling inhibits premature neural differentiation in the mouse embryo. Development 134: 3359-69 PubMed GONUTS page
- ↑ Yamaji N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem Biophys Res Commun 205: 1944-51 PubMed GONUTS page
- ↑ Dudley AT & Robertson EJ (1997) Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev Dyn 208: 349-62 PubMed GONUTS page