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MGI:Bmp7

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Bmp7 ( synonyms: OP1, osteogenic protein 1 )
Protein Name(s) bone morphogenetic protein 7,
External Links
MGI MGI:103302

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001503

ossification

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0892

P

From MGI

GO:0001654

eye development

MGI:MGI:3610441
PMID:16154126[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0001657

ureteric bud development

MGI:MGI:1289719
PMID:9693150[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0001707

mesoderm formation

MGI:MGI:3578079
PMID:15843411[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:2137520

P

From MGI

GO:0001822

kidney development

MGI:MGI:3610441
PMID:16154126[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136986

P

From MGI

GO:0005125

cytokine activity

MGI:MGI:77579
PMID:7590254[4]

TAS: Traceable Author Statement

F

From MGI

GO:0005515

protein binding

MGI:MGI:2662055
PMID:12741987[5]

IPI: Inferred from Physical Interaction

UniProtKB:P43029

F

From MGI

GO:0005515

protein binding

MGI:MGI:2681048
PMID:14623234[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q8CF09

F

From MGI

GO:0005515

protein binding

MGI:MGI:2683044
PMID:14660436[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q8VEA6

F

From MGI

GO:0005515

protein binding

MGI:MGI:3575605
PMID:15793581[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q6PB40

F

From MGI

GO:0005515

protein binding

MGI:MGI:3578079
PMID:15843411[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9ERN7

F

From MGI

GO:0005576

extracellular region

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

From MGI

GO:0005615

extracellular space

MGI:MGI:2662055
PMID:12741987[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O88684

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

C

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0007389

pattern specification process

MGI:MGI:77579
PMID:7590254[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0007411

axon guidance

MGI:MGI:2662055
PMID:12741987[5]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007435

salivary gland morphogenesis

MGI:MGI:2158598
PMID:11731698[9]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0008083

growth factor activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0339

F

From MGI

GO:0008083

growth factor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001839
InterPro:IPR001111
InterPro:IPR017948

F

From MGI

GO:0008201

heparin binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O88684

F

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3701027
PMID:16854970[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0009880

embryonic pattern specification

MGI:MGI:1332362
PMID:10049573[11]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0009887

organ morphogenesis

MGI:MGI:77579
PMID:7590254[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0010942

positive regulation of cell death

MGI:MGI:3623046
PMID:15342483[12]

IGI: Inferred from Genetic Interaction

UniProtKB:P97471

P

From MGI

GO:0030154

cell differentiation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

From MGI

GO:0030326

embryonic limb morphogenesis

MGI:MGI:1270933
PMID:9664686[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:88180

P

From MGI

GO:0030326

embryonic limb morphogenesis

MGI:MGI:1270933
PMID:9664686[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934010

P

From MGI

GO:0030501

positive regulation of bone mineralization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0030509

BMP signaling pathway

MGI:MGI:2681048
PMID:14623234[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030509

BMP signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0030855

epithelial cell differentiation

MGI:MGI:3765253
PMID:17878916[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136986

P

From MGI

GO:0031012

extracellular matrix

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O88684

C

From MGI

GO:0031988

membrane-bounded vesicle

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O88684

C

From MGI

GO:0034116

positive regulation of heterotypic cell-cell adhesion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0034504

protein localization to nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0035239

tube morphogenesis

MGI:MGI:3575981
PMID:15831470[15]

IDA: Inferred from Direct Assay

P

From MGI

GO:0040007

growth

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001111

P

From MGI

GO:0042325

regulation of phosphorylation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O88684

P

From MGI

GO:0042326

negative regulation of phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0042475

odontogenesis of dentin-containing tooth

MGI:MGI:3513220
PMID:15525533[16]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:3701027
PMID:16854970[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0043401

steroid hormone mediated signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0043407

negative regulation of MAP kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0045597

positive regulation of cell differentiation

MGI:MGI:3513220
PMID:15525533[16]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045665

negative regulation of neuron differentiation

MGI:MGI:3611623
PMID:16325379[17]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045665

negative regulation of neuron differentiation

MGI:MGI:3611623
PMID:16325379[17]

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0045666

positive regulation of neuron differentiation

MGI:MGI:1307014
PMID:9786991[18]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045669

positive regulation of osteoblast differentiation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0045746

negative regulation of Notch signaling pathway

MGI:MGI:3612905
PMID:16324690[19]

IGI: Inferred from Genetic Interaction

MGI:MGI:1099809

P

From MGI

GO:0045786

negative regulation of cell cycle

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0045839

negative regulation of mitosis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3654744
PMID:16801560[20]

IGI: Inferred from Genetic Interaction

MGI:MGI:1919200
MGI:MGI:1276116

P

From MGI

GO:0048468

cell development

MGI:MGI:3575981
PMID:15831470[15]

IDA: Inferred from Direct Assay

P

From MGI

GO:0048593

camera-type eye morphogenesis

MGI:MGI:3610441
PMID:16154126[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136986

P

From MGI

GO:0048593

camera-type eye morphogenesis

MGI:MGI:3701027
PMID:16854970[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0048596

embryonic camera-type eye morphogenesis

MGI:MGI:1332362
PMID:10049573[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0048646

anatomical structure formation involved in morphogenesis

MGI:MGI:1332362
PMID:10049573[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0048646

anatomical structure formation involved in morphogenesis

MGI:MGI:3701027
PMID:16854970[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0048646

anatomical structure formation involved in morphogenesis

MGI:MGI:3765253
PMID:17878916[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136986

P

From MGI

GO:0048754

branching morphogenesis of a tube

MGI:MGI:3575981
PMID:15831470[15]

IDA: Inferred from Direct Assay

P

From MGI

GO:0048762

mesenchymal cell differentiation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0048812

neuron projection morphogenesis

MGI:MGI:3611623
PMID:16325379[17]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0048812

neuron projection morphogenesis

MGI:MGI:3611623
PMID:16325379[17]

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0050768

negative regulation of neurogenesis

MGI:MGI:3722226
PMID:17699604[21]

IDA: Inferred from Direct Assay

P

From MGI

GO:0051216

cartilage development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0891

P

From MGI

GO:0060272

embryonic skeletal joint morphogenesis

MGI:MGI:1270933
PMID:9664686[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:88180

P

From MGI

GO:0060272

embryonic skeletal joint morphogenesis

MGI:MGI:1270933
PMID:9664686[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1934010

P

From MGI

GO:0060389

pathway-restricted SMAD protein phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0060395

SMAD protein signal transduction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0060445

branching involved in salivary gland morphogenesis

MGI:MGI:2158598
PMID:11731698[9]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0060485

mesenchyme development

MGI:MGI:1289719
PMID:9693150[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0060548

negative regulation of cell death

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0060686

negative regulation of prostatic bud formation

MGI:MGI:3612905
PMID:16324690[19]

IDA: Inferred from Direct Assay

P

From MGI

GO:0060687

regulation of branching involved in prostate gland morphogenesis

MGI:MGI:3612905
PMID:16324690[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136986

P

From MGI

GO:0060687

regulation of branching involved in prostate gland morphogenesis

MGI:MGI:3612905
PMID:16324690[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136986

P

From MGI

GO:0070487

monocyte aggregation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0070700

BMP receptor binding

MGI:MGI:70105
PMID:7811286[22]

ISO: Inferred from Sequence Orthology

UniProtKB:P22004

F

From MGI

GO:0072040

negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis

MGI:MGI:86404
PMID:9056639[23]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857654

P

From MGI

GO:0072125

negative regulation of glomerular mesangial cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI

GO:0072133

metanephric mesenchyme morphogenesis

MGI:MGI:3623046
PMID:15342483[12]

IGI: Inferred from Genetic Interaction

UniProtKB:P97471

P

From MGI

GO:0072134

nephrogenic mesenchyme morphogenesis

MGI:MGI:3623046
PMID:15342483[12]

IGI: Inferred from Genetic Interaction

UniProtKB:P97471

P

From MGI

GO:0072136

metanephric mesenchymal cell proliferation involved in metanephros development

MGI:MGI:3623046
PMID:15342483[12]

IGI: Inferred from Genetic Interaction

UniProtKB:P97471

P

From MGI

GO:1900106

positive regulation of hyaluranon cable assembly

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P18075

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Oxburgh L et al. (2005) BMP4 substitutes for loss of BMP7 during kidney development. Dev Biol 286: 637-46 PubMed GONUTS page
  2. 2.0 2.1 Godin RE et al. (1998) Regulation of BMP7 expression during kidney development. Development 125: 3473-82 PubMed GONUTS page
  3. 3.0 3.1 Zakin L et al. (2005) Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development 132: 2489-99 PubMed GONUTS page
  4. 4.0 4.1 4.2 Dudley AT et al. (1995) A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9: 2795-807 PubMed GONUTS page
  5. 5.0 5.1 5.2 Butler SJ & Dodd J (2003) A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons. Neuron 38: 389-401 PubMed GONUTS page
  6. 6.0 6.1 Laurikkala J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol 264: 91-105 PubMed GONUTS page
  7. Nakayama N et al. (2004) A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Development 131: 229-40 PubMed GONUTS page
  8. Lin J et al. (2005) Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med 11: 387-93 PubMed GONUTS page
  9. 9.0 9.1 Jaskoll T et al. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs 170: 83-98 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Morcillo J et al. (2006) Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH. Development 133: 3179-90 PubMed GONUTS page
  11. 11.0 11.1 11.2 Wawersik S et al. (1999) BMP7 acts in murine lens placode development. Dev Biol 207: 176-88 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Oxburgh L et al. (2004) TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131: 4593-605 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 Katagiri T et al. (1998) Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. Dev Genet 22: 340-8 PubMed GONUTS page
  14. 14.0 14.1 Suzuki K et al. (2008) Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4. Eur J Hum Genet 16: 36-44 PubMed GONUTS page
  15. 15.0 15.1 15.2 Leung-Hagesteijn C et al. (2005) Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol Cell Biol 25: 3648-57 PubMed GONUTS page
  16. 16.0 16.1 Wang XP et al. (2004) Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev Cell 7: 719-30 PubMed GONUTS page
  17. 17.0 17.1 17.2 17.3 Krizhanovsky V & Ben-Arie N (2006) A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech Dev 123: 67-75 PubMed GONUTS page
  18. Li W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J Neurosci 18: 8853-62 PubMed GONUTS page
  19. 19.0 19.1 19.2 19.3 Grishina IB et al. (2005) BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev Biol 288: 334-47 PubMed GONUTS page
  20. Suzuki A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A 103: 10294-9 PubMed GONUTS page
  21. Di-Gregorio A et al. (2007) BMP signalling inhibits premature neural differentiation in the mouse embryo. Development 134: 3359-69 PubMed GONUTS page
  22. Yamaji N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem Biophys Res Commun 205: 1944-51 PubMed GONUTS page
  23. Dudley AT & Robertson EJ (1997) Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev Dyn 208: 349-62 PubMed GONUTS page
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