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MGI:Bmp2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Bmp2 ( synonyms: Bmp2a ) | |
| Protein Name(s) | bone morphogenetic protein 2, | |
| External Links | ||
| MGI | MGI:88177 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1205964 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:892820 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001503 |
ossification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0892 |
P |
From MGI |
||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3528208 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99829 |
P |
From MGI |
||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3607617 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88182 |
P |
From MGI |
||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3837587 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3837587 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:87986 |
P |
From MGI |
||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3850932 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3850932 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1922667 |
P |
From MGI |
||
| GO:0001658 |
branching involved in ureteric bud morphogenesis |
MGI:MGI:3583399 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104903 |
P |
From MGI |
||
| GO:0001666 |
response to hypoxia |
MGI:MGI:4431313 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857894 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3611958 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583785 |
P |
From MGI |
||
| GO:0001837 |
epithelial to mesenchymal transition |
MGI:MGI:3044331 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001837 |
epithelial to mesenchymal transition |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:3718174 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001938 |
positive regulation of endothelial cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003130 |
BMP signaling pathway involved in heart induction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003181 |
atrioventricular valve morphogenesis |
MGI:MGI:3611958 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583785 |
P |
From MGI |
||
| GO:0003203 |
endocardial cushion morphogenesis |
MGI:MGI:3611958 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583785 |
P |
From MGI |
||
| GO:0003308 |
negative regulation of Wnt receptor signaling pathway involved in heart development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004745 |
retinol dehydrogenase activity |
MGI:MGI:3709664 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:83651 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2681048 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2683044 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3625588 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3722035 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:3044331 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006029 |
proteoglycan metabolic process |
MGI:MGI:4999722 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96533 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:83651 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007219 |
Notch signaling pathway |
MGI:MGI:3611958 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583785 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:3611958 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583785 |
P |
From MGI |
||
| GO:0008083 |
growth factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3583399 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104903 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:892820 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009790 |
embryo development |
MGI:MGI:83651 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857894 |
P |
From MGI |
||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:83651 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857894 |
P |
From MGI |
||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:3512872 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010718 |
positive regulation of epithelial to mesenchymal transition |
MGI:MGI:3611958 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583785 |
P |
From MGI |
||
| GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010922 |
positive regulation of phosphatase activity |
MGI:MGI:894584 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019211 |
phosphatase activator activity |
MGI:MGI:894584 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0021537 |
telencephalon development |
MGI:MGI:892820 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0021978 |
telencephalon regionalization |
MGI:MGI:2154554 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96785 |
P |
From MGI |
||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0030177 |
positive regulation of Wnt receptor signaling pathway |
MGI:MGI:3033512 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030282 |
bone mineralization |
MGI:MGI:3528531 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030282 |
bone mineralization |
MGI:MGI:3850932 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030282 |
bone mineralization |
MGI:MGI:3850932 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1922667 |
P |
From MGI |
||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:5009350 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030501 |
positive regulation of bone mineralization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:2681048 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3625588 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109452 |
P |
From MGI |
||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3718174 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3837587 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:4397715 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031648 |
protein destabilization |
MGI:MGI:3512872 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031648 |
protein destabilization |
MGI:MGI:3512872 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96396 |
P |
From MGI |
||
| GO:0031988 |
membrane-bounded vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0033690 |
positive regulation of osteoblast proliferation |
MGI:MGI:5009350 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035051 |
cardiac cell differentiation |
MGI:MGI:3044331 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035051 |
cardiac cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035054 |
embryonic heart tube anterior/posterior pattern specification |
MGI:MGI:3611958 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583785 |
P |
From MGI |
||
| GO:0035630 |
bone mineralization involved in bone maturation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0040007 |
growth |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:3513220 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042482 |
positive regulation of odontogenesis |
MGI:MGI:69105 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042487 |
regulation of odontogenesis of dentin-containing tooth |
MGI:MGI:894889 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88180 |
P |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:892820 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045165 |
cell fate commitment |
MGI:MGI:2429473 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045597 |
positive regulation of cell differentiation |
MGI:MGI:3513220 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045600 |
positive regulation of fat cell differentiation |
MGI:MGI:3050916 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:1307014 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:3050916 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:3587162 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:5009350 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045778 |
positive regulation of ossification |
MGI:MGI:3575204 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045778 |
positive regulation of ossification |
MGI:MGI:894584 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045786 |
negative regulation of cell cycle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1306711 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1306711 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1340783 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3611958 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583785 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3625588 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916835 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4431313 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:51994 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:80924 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:81256 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:892820 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046332 |
SMAD binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:70105 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048711 |
positive regulation of astrocyte differentiation |
MGI:MGI:1343608 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048711 |
positive regulation of astrocyte differentiation |
MGI:MGI:3577784 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048711 |
positive regulation of astrocyte differentiation |
MGI:MGI:3577784 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99414 |
P |
From MGI |
||
| GO:0048762 |
mesenchymal cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048839 |
inner ear development |
MGI:MGI:5140238 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050769 |
positive regulation of neurogenesis |
MGI:MGI:81256 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051216 |
cartilage development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0891 |
P |
From MGI |
||
| GO:0055008 |
cardiac muscle tissue morphogenesis |
MGI:MGI:3611958 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583785 |
P |
From MGI |
||
| GO:0060039 |
pericardium development |
MGI:MGI:3611958 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3583785 |
P |
From MGI |
||
| GO:0060128 |
corticotropin hormone secreting cell differentiation |
MGI:MGI:1202291 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060129 |
thyroid-stimulating hormone-secreting cell differentiation |
MGI:MGI:1202291 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060317 |
cardiac epithelial to mesenchymal transition |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060389 |
pathway-restricted SMAD protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060395 |
SMAD protein signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060804 |
positive regulation of Wnt receptor signaling pathway by BMP signaling pathway |
MGI:MGI:3850932 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0061036 |
positive regulation of cartilage development |
MGI:MGI:1353721 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0061036 |
positive regulation of cartilage development |
MGI:MGI:63446 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070700 |
BMP receptor binding |
MGI:MGI:70105 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0071363 |
cellular response to growth factor stimulus |
MGI:MGI:69105 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071407 |
cellular response to organic cyclic compound |
MGI:MGI:3835892 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0072138 |
mesenchymal cell proliferation involved in ureteric bud development |
MGI:MGI:3583399 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000726 |
negative regulation of cardiac muscle cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ McMahon JA et al. (1998) Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev 12: 1438-52 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Furuta Y et al. (1997) Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development 124: 2203-12 PubMed GONUTS page
- ↑ Young DW et al. (2005) SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J Cell Biochem 94: 720-30 PubMed GONUTS page
- ↑ Kugimiya F et al. (2005) Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem 280: 35704-12 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Mukherjee A & Rotwein P (2009) Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci 122: 716-26 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Friedman MS et al. (2009) Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J Biol Chem 284: 14117-25 PubMed GONUTS page
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