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MGI:Bmi1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Bmi1 ( synonyms: Bmi-1, Bmi1, Pcgf4 ) | |
| Protein Name(s) | Bmi1 polycomb ring finger oncogene, | |
| External Links | ||
| MGI | MGI:88174 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1098085 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1100253 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1932296 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99161 |
P |
From MGI |
||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000151 |
ubiquitin ligase complex |
MGI:MGI:3612587 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000151 |
ubiquitin ligase complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0001501 |
skeletal system development |
MGI:MGI:65743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857632 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:1932296 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99161 |
P |
From MGI |
||
| GO:0003682 |
chromatin binding |
MGI:MGI:3612587 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1100253 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1859418 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2389282 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3612587 |
IPI: Inferred from Physical Interaction |
UniProtKB:Q9QWH1 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3715707 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1100253 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006959 |
humoral immune response |
MGI:MGI:65743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857632 |
P |
From MGI |
||
| GO:0007420 |
brain development |
MGI:MGI:65743 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857632 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009987 |
cellular process |
MGI:MGI:65743 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016568 |
chromatin modification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0156 |
P |
From MGI |
||
| GO:0016573 |
histone acetylation |
MGI:MGI:3629244 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99161 |
P |
From MGI |
||
| GO:0016574 |
histone ubiquitination |
MGI:MGI:3612587 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016604 |
nuclear body |
MGI:MGI:2389282 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0021903 |
rostrocaudal neural tube patterning |
MGI:MGI:82985 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857632 |
P |
From MGI |
||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:3615850 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0031519 |
PcG protein complex |
MGI:MGI:3612587 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031519 |
PcG protein complex |
MGI:MGI:3628673 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031519 |
PcG protein complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0033092 |
positive regulation of immature T cell proliferation in thymus |
MGI:MGI:3615850 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035102 |
PRC1 complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:1932296 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99161 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4838928 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048103 |
somatic stem cell division |
MGI:MGI:3041338 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857632 |
P |
From MGI |
||
| GO:0048146 |
positive regulation of fibroblast proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048704 |
embryonic skeletal system morphogenesis |
MGI:MGI:1932296 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99161 |
P |
From MGI |
||
| GO:0048706 |
embryonic skeletal system development |
MGI:MGI:1932296 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99161 |
P |
From MGI |
||
| GO:0051443 |
positive regulation of ubiquitin-protein ligase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071535 |
RING-like zinc finger domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
|
contributes_to |
GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:3612587 |
IDA: Inferred from Direct Assay |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Schoorlemmer J et al. (1997) Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J 16: 5930-42 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Alkema MJ et al. (1997) MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex. J Mol Biol 273: 993-1003 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Akasaka T et al. (2001) Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development 128: 1587-97 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Cao R et al. (2005) Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 20: 845-54 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 van der Lugt NM et al. (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev 8: 757-69 PubMed GONUTS page
- ↑ Hemenway CS et al. (1998) The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains. Oncogene 16: 2541-7 PubMed GONUTS page
- ↑ 7.0 7.1 Suzuki M et al. (2002) Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 129: 4171-83 PubMed GONUTS page
- ↑ Sánchez C et al. (2007) Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol Cell Proteomics 6: 820-34 PubMed GONUTS page
- ↑ Fujimura Y et al. (2006) Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133: 2371-81 PubMed GONUTS page
- ↑ van der Lugt NM et al. (1996) The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech Dev 58: 153-64 PubMed GONUTS page
- ↑ 11.0 11.1 Bruggeman SW et al. (2005) Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev 19: 1438-43 PubMed GONUTS page
- ↑ Lorente M et al. (2006) Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech Dev 123: 312-20 PubMed GONUTS page
- ↑ Onodera A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med 207: 2493-506 PubMed GONUTS page
- ↑ Park IK et al. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423: 302-5 PubMed GONUTS page
