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MGI:Blm
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Blm | |
| Protein Name(s) | Bloom syndrome, RecQ helicase-like, | |
| External Links | ||
| MGI | MGI:1328362 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000079 |
regulation of cyclin-dependent protein kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000166 |
nucleotide binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0000405 |
bubble DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0000723 |
telomere maintenance |
MGI:MGI:3055614 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109635 |
P |
From MGI |
||
| GO:0000733 |
DNA strand renaturation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000739 |
DNA strand annealing activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0000800 |
lateral element |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0001673 |
male germ cell nucleus |
MGI:MGI:3719060 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0002039 |
p53 binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR011545 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003697 |
single-stranded DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004003 |
ATP-dependent DNA helicase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004386 |
helicase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3053255 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005657 |
replication fork |
MGI:MGI:3053255 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3774867 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006200 |
ATP catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006260 |
DNA replication |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0235 |
P |
From MGI |
||
| GO:0006260 |
DNA replication |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006281 |
DNA repair |
MGI:MGI:3053255 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006310 |
DNA recombination |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008026 |
ATP-dependent helicase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009378 |
four-way junction helicase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0010165 |
response to X-ray |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016363 |
nuclear matrix |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016605 |
PML body |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0016818 |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0016887 |
ATPase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031297 |
replication fork processing |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032508 |
DNA duplex unwinding |
MGI:MGI:1315081 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032508 |
DNA duplex unwinding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043140 |
ATP-dependent 3'-5' DNA helicase activity |
MGI:MGI:1315081 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0044237 |
cellular metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0045120 |
pronucleus |
MGI:MGI:3774867 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045910 |
negative regulation of DNA recombination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045950 |
negative regulation of mitotic recombination |
MGI:MGI:1312959 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857708 |
P |
From MGI |
||
| GO:0045950 |
negative regulation of mitotic recombination |
MGI:MGI:1928200 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158669 |
P |
From MGI |
||
| GO:0045950 |
negative regulation of mitotic recombination |
MGI:MGI:3655554 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857708 |
P |
From MGI |
||
| GO:0045950 |
negative regulation of mitotic recombination |
MGI:MGI:3700903 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3663359 |
P |
From MGI |
||
| GO:0046632 |
alpha-beta T cell differentiation |
MGI:MGI:3700903 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3663359 |
P |
From MGI |
||
| GO:0046641 |
positive regulation of alpha-beta T cell proliferation |
MGI:MGI:3700903 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3663359 |
P |
From MGI |
||
| GO:0051098 |
regulation of binding |
MGI:MGI:3053255 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051259 |
protein oligomerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051276 |
chromosome organization |
MGI:MGI:1312959 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857708 |
P |
From MGI |
||
| GO:0051276 |
chromosome organization |
MGI:MGI:3505667 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158670 |
P |
From MGI |
||
| GO:0051782 |
negative regulation of cell division |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051880 |
G-quadruplex DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Du X et al. (2004) Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol 24: 8437-46 PubMed GONUTS page
- ↑ Li XC & Schimenti JC (2007) Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet 3: e130 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Sengupta S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 166: 801-13 PubMed GONUTS page
- ↑ 4.0 4.1 Liu L et al. (2007) Telomere lengthening early in development. Nat Cell Biol 9: 1436-41 PubMed GONUTS page
- ↑ 5.0 5.1 Bahr A et al. (1998) Point mutations causing Bloom's syndrome abolish ATPase and DNA helicase activities of the BLM protein. Oncogene 17: 2565-71 PubMed GONUTS page
- ↑ 6.0 6.1 Chester N et al. (1998) Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. Genes Dev 12: 3382-93 PubMed GONUTS page
- ↑ Luo G et al. (2000) Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nat Genet 26: 424-9 PubMed GONUTS page
- ↑ Chester N et al. (2006) Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol Cell Biol 26: 6713-26 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Babbe H et al. (2007) The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol 27: 1947-59 PubMed GONUTS page
- ↑ Wang Y & Heddle JA (2004) Spontaneous and induced chromosomal damage and mutations in Bloom Syndrome mice. Mutat Res 554: 131-7 PubMed GONUTS page
